In vivo, substantia nigra pars compacta (SNc) dopaminergic neurons exhibit three spiking patterns – irregular, regular, and bursting. These distinct modes of activity are thought to underlie the different roles that dopamine (DA) plays in target structures within the basal ganglia. In particular, burst spiking in SNc DA neurons is...
My research interests, which span organic, inorganic, physical and biochemistry, have focused broadly on photo-, magneto- and redox-active molecules, especially those with potential applications in organic photovoltaics, spintronics and electronics. My research under the joint supervision of Professor Wasielewski and Professor Fraser Stoddart has concentrated upon understanding electronic and magnetic...
The study of tumor metabolism from the middle of the 20th century through the early 21st almost entirely ignored the mitochondria; instead, the field focused on cancer cells use of glycolysis even when oxygen was not limiting, termed aerobic glycolysis. Due to this observation, it was often speculated that malignant...
This dissertation consists of three essays in applied microeconomics. In the first chapter, I introduce a new statistical test for identifying prejudice from empirical data. In the second chapter, I (joint with James Schummer) consider the revenue maximization problem for a two-sided, one-to-one matching platform. In the third chapter, I...
Certain inducible genes show faster reactivation if they were recently expressed. This epigenetic phenomenon is called transcriptional memory and is inherited for several generations after the first round of induction. During this phase, genes show several conserved molecular features that are essential for faster reactivation: peripheral localization of the gene,...
The electronic spin state (S) of metal ions is fundamental to the performance of magnets, protein cofactors, and magnetic resonance imaging (MRI) contrast agents. The ability to manipulate the spin state of transition metals allows for the development of advanced materials with emergent properties. This following chapters will introduce two...
This dissertation looks at the consequences of three different government regulatory policies---the nondistribution constraint (which prohibits managers of nonprofit organizations from distributing profits generated by the nonprofit organization to themselves), the 100/0, 85/15, and 90/10 rules (which restrict the fraction of revenue for-profit colleges and universities can receive from Title...
Technology has advanced rapidly, especially in the twenty-first century, influencing our day-to-day life on unprecedented levels. Most such advances in technology are closely linked to, and often driven by, the discovery and design of new materials. It follows that the discovery of new materials can not only improve existing technologies...
The work presented in this dissertation examines the interplay between electron transfer reactions and electron spin in photoactive organic molecules. Organic compounds that undergo electron transfer reactions after absorbing light are important in natural photosynthesis, photobiology, and synthetic photovoltaics. These electron transfer reactions depend on the spin states of the...
Microkinetic modeling is a powerful tool for creating dynamic and quantitative descriptions of complex systems. These detailed mechanistic models compliment experimental techniques and provide an ability to achieve deeper insights into chemical processes where numerous intermediates are highly reactive and difficult to quantify in the laboratory. This thesis discusses the...