This research questions how institutional logics shape and change through the event sequencing of institutional reforms. Literature reviewed on sequences of social events underspecifies the enchainment of events, i.e., the set of social processes that both links events and also renders the sequence meaningful beyond summing its individual events. My...
Superconducting-circuit based platforms are strong contenders in the race to build a quantum computer.While the transmon has had extraordinary success as the leading superconducting qubit modality, there are reasons to believe that other types of qubits could possess relative benefits in terms of noise immunity, anharmonicity, or extensibility. In this...
Fat represents an important source of energy for ovarian cancer (OC) cells and is supplied either through import from the tumor milieu or via de novo lipogenesis. During fast tumor growth, when nutrients are scarce, lipogenesis becomes the primary source of fatty acids. Stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in...
From the early usage of metallic thin films as mirrors tracing back to 2900 BC, to the modern thin film photonic circuits as a mature optical processing platform, and to the growing class of atomically-thin two-dimensional (2D) materials with diverse and tailorable properties, thin film materials have played an important...
Since the dawn of mankind, humans have used materials and tools to dominate the world. As our understanding of the fields physics, chemistry and engineering is growing, we are able to artificially create advanced materials with engineered responses. Next step would be to create ‘ smart’ or intelligent materials capable...
Public-facing data-driven technologies such as social media platforms and search engines rely on data producers, such as users and crowd workers, to be feasible and financially sustainable. Recently, it became clear that the goals of these data-driven technologies do not always align with those of the public, causing public backlashes...
Deterministic models are used to explain and predict the dynamics of ecosystems featuring cyclic competition schemes. The models are systems of reaction-diffusion partialdifferential equations that account for species mobility via Fickian diffusion and interspecies interactions according to the competition scheme. Length and temporal scales are
chosen to be appropriate for...
From colonial practices designed to civilize indigenous communities, to counter-terrorism initiatives aimed at de-radicalizing dissidents in the wake of the War on Terror, to controversies over blasphemy and religious harm cases in international law, religious passions have been cast as a specter of unreason, treason, and radicalization. These assumptions sustain...
Cellular translation is responsible for the synthesis of proteins, a highly diverse class of macromolecules that form the basis of biological function. In Escherichia coli, harnessing and engineering of the biomolecular components of translation, such as ribosomes, transfer RNAs (tRNAs) and aminoacyl-tRNA synthetases, has led to both biotechnology products (i.e.,...
Synthesis and characterization of mixed valent molecules which contain two or more metals in different oxidation states is a rich field of chemistry informing fundamental electronic structure and electron transfer theories. Traditionally these studies are concerned with the direct electronic interaction between metals, but recent work on redox non-innocent ligands...
Visual understanding is an important area in artificial intelligence. Many researchers have proposed novel deep learning models for this, which have achieved impressive results. However, deep learning models of visual understanding do not model human-like cognition and are still far from human-level ability. Standard deep learning models do not model...
In this dissertation, I summarize my findings of the dynamics of colloidal suspensions over a large range of volume fractions in two systems: drop impact and film rupture. The existence of a deformable surface in both these systems allows me to capture the consequences of non-Newtonian flow using high-speed imaging....
Understanding the mechanisms associated with chemical catalysis is vital for not only the rational improvement of their capabilities, but also for the advancement of the fundamental knowledge affiliated with the systems in question. These new insights can help predict new reactivities towards more challenging substrates which will allow for easier...
Dynamical modeling aims to capture the essential mechanics at work in real-world systems while remaining tractable enough to yield mathematical insights for predictions and interventions. The work presented here first takes this approach to the system of political ideology and influence, establishing a model for the continuous-time evolution of individual...
Chapter 1: If patients can be persuaded to switch between licensed providers on the basis of authoritative opinions, policy-makers can harness such reporting as a tool to implement incentives for high-quality care. I employ the landmark Flexner Report (1910) medical school evaluations to show that existing consumer beliefs and market-specific...
Elemental powder blends are an emerging alternative to prealloyed powders for high-throughput alloy design via additive manufacturing techniques due to their flexibility, low cost, and ease of customization. This dissertation investigates elemental alloying elements (Sc and Zr) which are high-melting and highly reactive, unlike previous work which focused on more...
This dissertation argues that writers and artists in Britain and its Empire in the first half of the twentieth century turned time and again to games and sports to find images and forms for their literary and artistic interventions. Furthermore, it shows how, in these works, play served as a...
Dark matter (DM) is one of the most outstanding problems in physics and is a promising hint for physics beyond the Standard Model. Many dark matter detection experiments have been built, with weakly-interacting massive particles (WIMP) as a popular DM candidate. There are also growing interest in light (keV-GeV)...
The increasing demand for green energy has created great demand for high purity lanthanide elements because of their wide range of applications, such as in permanent magnets, batteries, and high-energy capacitors. Solvent extraction, which transfers ions from aqueous solutions to organic liquid phases with the support of extractant molecules, is...
Over the last decade, a rising trend of corporations publicly acting on social and political issues has come to the fore. The issues and methods have both varied widely—from immigration to abortion, and from advertisements to boycotts. This introduces an interesting puzzle in the realm of strategy research: Where does...
The escalating climate crisis is a global social problem requiring multidisciplinary and multi-institutional coordination to solve. In recent years, health practitioners and institutions have become increasingly involved in the climate crisis, recognizing that climate change poses a serious public health threat across a range of health issues. This dissertation draws...
This dissertation studies the integration of analytical modeling and optimization, machine learning, and Bayesian learning to optimize cost, access, and quality of healthcare delivery. Chapter 1 models computer-aided triage (patient prioritization) as feature-based priority queuing where types (diseases) are not perfectly observed but are inferred from observed features using a...
Protein-based biomaterials are widely used in biomedical applications and mechanical support because of their novel structural flexibility, biocompatibility and mechanical properties. Protein-based biomaterials outperform traditional synthetic materials in various environments as traditional materials lack the diverse chemical functionalities that proteins offer. Novel bioinspired techniques such as directed evolution offer the...
While there is high demand for university computer science (CS) courses, students often struggle when learning to program. Prior work has identified that student perceptions of their programming ability may contribute to these challenges. For example, studies show that students often perceive that they do not belong, are not capable...
This multi-study dissertation explored technology and creativity within three different technology-rich creative musical spaces. Through the use of three contrasting empirical methods (qualitative content analysis, intrinsic case study, and phenomenology), I explored the complex ways technology and musical creativity are linked. In the first study, I completed a content analysis...
Before initiating a walking movement, the central nervous system forms a motor plan, a set of motor commands predicted to accomplish task-specific goals. To be effective, motor plans must be continually updated to consider an ever-changing external environment. Despite being an inherent part of walking, how the nervous system adapts...
Protein-protein interactions are ubiquitous in living systems, and mediate important cellular processes from decision making to immunity against pathogens. Furthermore, protein-protein interactions are key to many protein therapeutics, pathogen diagnostics, and numerous synthetic biology applications. As a result, there has been significant effort to develop methods to express potential protein...
In this document, I demonstrate that: 1) Linear basis functions cannot outperform nonlinear ones to represent hand kinematics 2) Nonlinear autoencoders outperform PCA on the dimensionality reduction of hand kinematics, 3) Nonlinear autoencoders outperform PCA in human gait representation and recurrent nonlinear autoencoders can seamlessly express the temporal dynamics, 4)...
Electrical spinal cord stimulation is an emerging treatment for spinal cord injury that can improve walking and bladder control, among many other functions. While the anatomical location of the motor pools for muscles involved in locomotion in the lumbosacral cord has been identified, the map of the functional output of...
The current view in neuroscience holds that the brain, together with its sensory and motor structures and the environment, form a closed-loop system – a sensorimotor loop – in which the brain receives information from the environment and converts it into a motor response while simultaneously making predictions about future...
Affect represents a major domain of human consciousness, consisting of a complex group of psychophysiological processes to drive human behavior. Many genetic and environmental factors may cause dysregulation of affective states, resulting in disorders that severely disrupt normal cognitive function and diminish the quality of life. Transitions among affective states...
Memory management and address translation need significant optimizations in order to not behindrances in the near future. Currently, plenty of work has started to address issues within the
current abstraction of the hardware-software codesign of paging. I argue that a new abstraction
is needed in order to properly address this...
Vimentin intermediate filaments (VIFs) provide mechanical integrity to cells and serve as markers of tissue origin and cell differentiation. Several non-mechanical roles for vimentin have recently been reported, including regulation of key pathways that control cell growth, cell signaling, and cell motility. Here, I present the role of vimentin in...
People are exposed to inaccurate claims and ideas every day, from sources intended to inform, entertain, or do both. A large body of research has demonstrated that exposure to inaccurate statements, even when conveying obviously false ideas, can affect people’s subsequent judgments. Contemporary accounts suggest that these effects may be...
We are witnessing an excitement about digital games and related immersive media as these become ever more prevalent in the world. Governments, private companies, and research institutes are investing in these technologies in hopes of transforming education. However, while scholarship on digital game-based learning has been steadily growing over the...
Transfer of information across membranes is fundamental to the function of all organisms and is primarily initiated by transmembrane receptors. This is an allosteric process and involves conformational coupling between ligand-binding domain and signaling domain of a receptor. This allosteric mechanism of activation is unclear for many receptors. Moreover, for...
This dissertation assesses the relationship between inequality and the longevity of urban communities. It does so through an examination of low-status households, a population segment I term Urban Commoners, at the ancient Maya city of Aventura, Belize. Aventura was a socioeconomically diverse urban center that grew to its peak in...
Breakthroughs in large-scale biological data collection have resulted in a wealth of -omics (genomics, metabolomics, etc.) datasets in the literature. However, the development of appropriate computational techniques for their analysis is lacking, yet crucial for fully extracting the rich information contained in these datasets. The work in this dissertation describes...
Shoulder (glenohumeral joint) osteoarthritis causes pain, limits daily activities, and frequently requires joint replacement surgery. In shoulder osteoarthritis, the glenoid bone surface erodes in one of two ways: symmetrically (concentric deformity) or asymmetrically (eccentric deformity). Shoulder replacements in patients with eccentric deformities fail and require additional, revision surgery more often...
Conventional polymer networks are composed of strong, fixed covalent cross-links. The covalent cross-links render polymer networks with outstanding mechanical properties, heat stability, and chemical resistance; however, they also prevent polymer networks from being decross-linked or/and recycled into similar-value products at the end of their life, leading to environmental and economic...
The creative process of an artistic work is a space, figuratively, in which every facet of our personal lives has an effect and, in turn, can be explored and altered. One of the most fundamental aspects of life, be it human or not, is the way in which one relates...
In 2009, the Health Information Technology for Economic and Clinical Health Act (HITECH) promoted national use of electronic health records (EHR) in the US by giving incentives to providers who adopt ‘meaningful use’ of EHRs. As of 2017, nearly 86% of office-based physicians had adopted EHRs. EHRs have rich information...
ABSTRACTFor several decades, dams have played an essential role in human development. In many low-and middle-income countries (LMICs), the construction of dams remains an integral part of industrialization and modernization. However, dam construction and associated infrastructure have significantly contributed to socioecological destruction and population displacement. For example, the construction of...
One of the pressing concerns of the fifteenth century was monastic reform, and reformers of the Observant movement rose to meet the challenge by attempting to return monastic houses to stricter observance of their earliest rules and governing documents. In this dissertation, I examine how Dominican nuns in German-speaking parts...
For some inducible genes, the rate and molecular mechanism of transcriptional activation depend on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation, and requires both changes in chromatin structure and recruitment of poised RNA polymerase II (RNAPII) to the promoter. A well-established model for...
Advances in methods to sequence and manipulate DNA have enabled systems that enzymatically encode information in cellular DNA in situ. These systems, broadly categorized as molecular recorders, couple signals of interest to the expression of DNA modification enzymes, resulting in signal-dependent changes in DNA sequence. While a variety of molecular...
Preterm birth (PTB) is the leading cause of infant morbidity worldwide. Approximately 380,000 babies are born prematurely in the USA every year. Estrogen (E2) and progesterone (P4) play essential roles during pregnancy and labor; a clear understanding of their action mechanisms, however, is lacking. E2 and P4 function by activating...
With the potential to bypass congested urban road networks and take advantage of the openness of the sky, advanced air mobility (AAM) promises to provide a faster alternative mode for people and goods. However, AAM will also require a new paradigm for the movement of aircraft around an airspace network...
Carbon nanomaterials, such as graphene and graphene oxide, have outstanding mechanical strength, stiffness, and toughness that surpass those of materials currently used to build structures. However, these properties are limited to the nanoscale and have not yet been attained in macroscopic composites containing carbon nanomaterials. To integrate the mechanical properties...
This dissertation models and simulates optimization problems to find the optimal set of strategies to allocate network space (lanes or zones) to autonomous vehicles (AVs) in partially automated dynamic networks. This dissertation aims to develop a set of methods to determine the appropriate AV managed space strategies. Managed space strategies...