This thesis proposes a robust multi-pronged approach to study the effect of nanoparticles on cells. In the first place, this work is focused on investigation of the protein corona that accumulates on the surface of nanoparticles internalized by the cells and their poly-pathway effects on protein availability and messenger RNA...
Manufacturing processes are known for their intricacies in changing material shapes and properties. New generations of manufacturing technologies, known as flexible manufacturing, are moving toward design freedom, which allows producing parts with optimized geometries and high customizations at an affordable cost even for low-volume productions. Two prominent flexible manufacturing processes...
Chemokines, such as Stromal Derived Factor 1 (SDF-1 or CXCL12) and their G protein coupled receptors (GPCRs) are well known regulators of the development and functions of numerous tissues. CXCL12 has two receptors: CXCR4 and CXCR7 or atypical chemokine receptor 3 (ACKR3). CXCR7 has been described as an atypical “biased”...
The explosion of data in the digital age has provided new possibilities for policy creation,the development of knowledge, and societal innovations. In this way, data becomes an essential
tool in personal decision-making, legal change, and policy creation as we leverage new forms of
data to understand social phenomena. But along...
Cyber-physical systems (CPS), as a multidisciplinary area, have been widely adopted in our daily life and attract experts from various fields. CPS aims to achieve real-time and resilient connection with physical world through integration of computation, communication and control technologies. Many CPS systems, such as automotive, avionics, and industrial system,...
High-throughput methods enable rapid experimentation and/or screening of thousands of samples simultaneously. Mass-spectrometry based methods are of particular interest since they provide a label-free way to detect all species present in a given reaction mixture. To circumvent sample preparation and purification—which is typically a slow process—the Mrksich group developed a...
“Embodying Race, Performing Citizenship” investigates racial and ethnic impersonationsin American popular entertainment, especially vaudeville, between the 1870s and the 1920s. I
focus my analyses on first-generation Irish, Chinese, and Jewish Eastern European artists and
their American-born children during a time when the United States had absorbed the highest
number of...
Optical microscopy is one of the most ubiquitous tools for functional imaging of biological phenomena. While relatively non-destructive to living organisms, light microscopy’s spatial resolution is diffraction limited, restricting the minimum resolvable features. On the other hand, high resolution techniques such as electron microscopy or STORM, have several orders of...
Neutron star mergers instigate a wealth of observable astrophysical signals, offering key insights into interdisciplinary questions in stellar astronomy, nuclear physics, cosmology, and atomic physics. The coalescence of neutron stars and/or black holes produces gravitational wave emission, only recently accessible to ground-based laser-interferometric detectors. Additionally, these mergers can incite emission...
From its inception in the early 1900s, vocational education in American high schools was designed to prepare students for jobs that did not require any formal postsecondary education. In the last decades of the 20th century, growing concern about how separating students into “college” and “non-college” tracks often perpetuated racial...