Inter-organelle contact sites have become increasingly appreciated as important regulators of cellular homeostasis, and disruption of inter-organelle contact site dynamics and function has been observed in various pathologies. Recently, inter-organelle contact sites between mitochondria and lysosomes were discovered, offering a new mechanism by which these two organelles may directly interact,...
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and associated with increased risk for ischemic stroke and mortality. While the risk of stroke has been shown to be reduced with the use of oral anticoagulants like Warfarin, these medications are predictably linked with an increased risk of bleeding, and...
Pathogenic bacteria scavenge essential nutrients including metals, amino acids and peptides to survive within the hostile host environment. Bacteria utilize ATP-binding cassette (ABC) transporters, powered by the energy of ATP hydrolysis, to move substrates across cellular membranes. The substrate-binding protein (SBP) shuttles substrate in the periplasm and directs the substrate...
Sound is one of the most important mediums to understand the environment around us. Identifying a sound event in prerecorded audio (such as a police siren, a dog bark, or a creaking door in soundscapes) leads to a better understanding of the context where the sound events occurred. To do...
This dissertation investigates a number of models and algorithms in the context of optimization under uncertainty. The focus is on risk-averse optimization, where risk aversion is modeled via stochastic dominance, utility theory, and distributionally robust optimization. We first investigate an investment model with fixed contribution rates, optimize asset-allocation decisions in...
Supported vanadium oxide materials have been extensively studied for alkane oxidative dehydrogenation (ODH) reactions due to their high activity and selectivity. The catalytic activity of supported VOx materials is influenced by the surface coverage of VOx sites and hence the distribution of V=O, V-O-V, and V-O-S (S, support) bonds. The...
Active lateral force feedback is essential for haptic applications in which forces on the fingertip is perpendicular to or in the same direction of finger movement, such as virtual shape rendering and button click rendering. In this thesis, I first present a novel device, the UltraShiver, that can provide large...
In recent decades, mass loss from glaciers and ice caps (GICs) worldwide has accelerated, contributing significantly to the observed sea–level rise. Their continued melt is also expected to alter local hydrological systems, affecting freshwater availability and quality. Despite these problematic impacts, little is known about GIC variations prior to the...
Increasingly high global energy consumption demands effective approaches to high energy efficiency and, at the same time, paths to reduced release of carbon dioxide, a primary greenhouse gas behind global climate change. Friction reduction is a vital aspect towards making energy systems more efficient and one of the most crucial...
The investigation of ceria-related materials has a long history since 1920s. The first publication on web of science traces back to 1928. Ever since that, more studies come out and surge starting from 1987. This material has attracted extensive attention due to its wide applications in electrochemical devices, catalysis, and...
Polyolefins are the most versatile and widely used polymers worldwide. Depending on the polymer microstructure, polyolefins can exhibit a wide range of useful and tailored properties and applications. Metal-catalyzed coordinative olefin polymerization plays a center role in advancing polyolefin synthesis. This dissertation explores two strategies to modulate the polymer microstructures...
In this thesis I focus on two topics: planet-disk interaction and solar convection. These two seemingly separate topics are connected via a similar separation of timescales. Planets excite spiral waves in their disks on fast timescales compared to the time for the disk to viscously adjust to the angular momentum...
This thesis provides an introduction to decay rates for the damped wave equation on compact manifolds. It also gives a proof of a sharp decay rate for solutions to the damped wave equation on the torus with damping of a particular polynomial form. Finally it gives a proof of a...
How we remember, narrate and teach the past is an inherently political and ethical act. This is especially true when teaching about race and racism within the context of United States history. In this dissertation, I ask: how do young people narrate the durability of racial inequality in the United...
Despite its demonstrated effectiveness, exposure therapy – repeatedly approaching a fear/anxiety trigger – is not widely used in the treatment of anxiety disorders. This may be due to its image as an aversive (and even harmful) approach to treatment and its reduced rates of compliance among patients. However, if exposure...
The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal domain that permits mitochondrial binding, but its physiologic significance remains unclear. We generated mice lacking the HK1 mitochondrial-binding...
Digitization has led to dramatic cost reductions and reshaped both what and how products are sold. This dissertation examines the impact of digitization on the behavior of market intermediaries that bring together producers and consumers. Our empirical context is the transition from 35mm film to digital cinema technologies in the...
Students pursue educational and career future identities (e.g., graduating college, becoming an engineer, etc.) that are tied to their deepest wants, desires, and needs, yet many find it difficult to exert self-control and resist temptations while pursuing these identities (e.g., studying versus watching TV, paying attention in class versus scrolling...
This dissertation is a collection of three papers on synthesizing and translating statistical evidence in education research. Chapter 1 serves as an introduction and executive summary, and Chapters 2 - 4 contain the three substantive papers respectively. Chapter 2 presents methods for pooling sample variances across studies to improve properties...
We study modular forms, Jacobi forms, and hermitian formal Fourier-Jacobi series over imaginary quadratic fields. In the first section, we prove that the ring of classical Jacobi forms of a fixed genus g, varying index m and weight k is generated by theta functions. From this result we show that...
Anthropogenic consumption of fossil fuels releases carbon into the Earth-atmosphere-ocean system at rates unmatched by geologic processes. Yet, some geologic time periods also show evidence of climate forcing related to rapid natural greenhouse gas emissions and can serve as tools to help understand the future trajectory of climate. Geologic events...
The question of how native species diversity affects a community’s ability to resist invasive species has inspired decades of research. One of the oldest invasion biology hypotheses is that more species rich ecosystems are less invaded. While there has been strong support for this hypothesis, there is also strong evidence...
Two-dimensional (2D) materials and heterostructures have attracted significant attention for a variety of nanoelectronic and optoelectronic applications. At the atomically thin limit, the material characteristics and functionalities are dominated by surface chemistry and interface coupling. Therefore, methods for comprehensively characterizing and precisely controlling surfaces and interfaces are required to realize...
In this thesis, we aim to develop efficient algorithms with theoretical guarantees for noisy nonlinear optimization problems, with and without constraints, under various different assumptions. Apart from Chapter 1 which provides relevant backgrounds, the remaining of thesis is divided into four chapters. In Chapter 2, we establish the theoretical convergence...
The purpose of this study was (1) to examine the impact that small ensemble free improvisation experiences had on dispositional empathy development when compared with other forms of collective music making; and (2) to examine the relationship between co-performing musicians’ empathy levels and their performance achievement in small ensembles using...
There is no group of materials as diverse, complex, and ubiquitous as polymers. From plastic bags, to rubber tires, electronics, food packaging, water filtration and even aerospace applications, the penetration of polymer materials into all aspects of life make them very important materials throughout all engineering fields. However, this breadth...
Recent advances in combinatorial chemistry, synthetic biology, and ‘omics’ research require high-throughput methods for performing and analyzing thousands to millions of reactions in one day. However, it is a challenge to engineer high-throughput systems that can autonomously conduct and analyze such a large number of reactions in a generalizable and...
Brain network organization, the emergence of cognition, and the accumulation of neurodegenerative pathology are interwoven concepts frequently studied under the umbrella of behavioral neurology, neuropsychiatry, neuropsychology, and neuropathology. One approach to studying the organization of cognitive processes is to study those with selective deficits in such networks. To understand how...
Successful restoration depends on the establishment and survival of selected species, and sowing seed is the most cost-effective method to ensuring a successful restoration. Generally, a locally sourced seed is thought to be better adapted to local environmental conditions and, therefore, more likely to thrive. In addition, a local seed...
Contest theory is an area of game theory that studies environments in which agents make sunk investments in order to get a prize. These investments could be money, effort, time, etc. Contest theory is used to study a wide range of applications, like political contests, research and development, advertisement campaigns,...
On 14 January 2017, President Donald J. Trump described the North Atlantic Treaty Organization (NATO) as obsolete. During the first six months of his administration, President Trump discussed not honoring Article 5 commitments for NATO members who had not met the financial responsibilities outlined in the 2014 Wales Summit. His...
Records of temperature and precipitation during Quaternary interglacial periods on Greenland are notably scarce, limiting assessment of the magnitude and rate of local environmental response to orbitally-driven Arctic warming. It is largely unknown if warming across Greenland was spatially uniform through past interglacials, and if warming was accompanied by major...
Research on how sleep contributes to memory has blossomed in recent years. These studies have generally focused on whether or not sleep impacts various types of memory independently. An open question is whether sleep interactively influences different memory types. My research focuses on two types of memory—specificity and generalization. Whereas...
As the global population grows, consumption of water, energy, and food will also increase, placing stresses on these sectors, raising the importance of the Water-Energy-Food Nexus (WEFN). However, operation of WEFN systems are currently not sustainable. It is thus crucial to design WEFN systems to be sustainable from local to...
In three empirical chapters, this dissertation examines the field of sustainability over time, specifically uncovering the processes by which contentious interactions between movements and organizations can shift to the development of shared meaning and the creation of new organizational positions. The dissertation utilizes the analyses strategies of text analysis, field...
In the absence of any significant federal policy to mitigate climate change, many (though not all) U.S. states have stepped in to fill the void. But the policies these states have adopted vary considerably in their quality. For example, California’s economy-wide greenhouse gas policy was significantly stronger than Massachusetts’, which...
Uterine leiomyoma (LM), the most common tumor of women, causes severe morbidity. LM cells can be separated into three molecularly and functionally distinct cell populations based on the expression pattern of CD34 and CD49b: stem (LSC, CD34+/CD49b+), intermediate (LIC, CD34+/CD49b-), and differentiated cells (LDC, CD34-/CD49b-). Progesterone via progesterone receptor (PR/PGR)...
This thesis focuses on the application of neural networks to three types of classification tasks, each work with its own chapter. The objective of the first work is to take advantage of deep neural networks in order to make next day crime count predictions in a fine-grain city partition. We...
Store-operated Ca2+ entry (SOCE) is a principal mechanism for generating cellular Ca2+ signals. Store-operated Ca2+ release-activated Ca2+ (CRAC) channels serve an essential role in generating Ca2+ elevations needed for transcriptional, enzymatic, and secretory effector cascades in many cell types. CRAC channels, comprised of the ER Ca2+ sensor STIM and the...
Human complex diseases such as common cancers and diabetes are characterized by high molecular heterogeneity contributed by both genetic and non- genetic factors. This molecular heterogeneity can not only complicate diagnosis, risk stratification and patient care, but also lead to differential therapeutic response and treatment efficiency. Therefore, understanding the molecular...
Non-covalent and ion-specific interactions in the context of charged polymers are ubiquitous in nature and in synthetic applications. For example, mussels utilize metal-coordinate bonds to form tough underwater adhesion to a wide range of substrates. The sandcastle worm uses coacervation of oppositely charged polymers to build robust structures for self-defense....
The structure of the North American crust and mantle was investigated using P wave teleseismic tomography and the links between seismic tomographic models, locations of volcanism, sediment isopachs, and continental scale crustal structures via plate reconstruction modeling. Nearly 50,000 teleseismic P wave delay times were measured from seismograms recorded by...
ABSTRACTUnderstanding Micro-macroscopic Phenomena of Tribological Fluids and Surfaces
Mechanical power and motion are transmitted through interfaces under contact and relative motion. Friction is inevitable, which can lead to higher operating and energy costs, and severe frictional rubbing can result in material damage and cessation of motion. A deep understanding of...
Low-dimensional materials have emerged as a promising platform for ultrathin electronic and optoelectronic devices. The span of electronic properties covers the spectrum from metallic through small and medium bandgap semiconductors to large bandgap insulators, providing all the necessary components to fabricate a variety of devices. Compared to bulk-semiconductor based devices,...
This dissertation researches the Cenomanian, Turonian, and Coniacian Stages (100.5 - 86.3 Ma) of the Cretaceous Period, a geologic interval of interest due to its extreme global warmth, iconic faunas, and oceanic anoxic events (OAEs). Five globally dispersed geochemical and stratigraphic case studies reconstruct interactions of the mid-Cretaceous carbon cycle...
The effective capture and detoxification of chemical warfare agents (CWAs) is a pressing need in the modern world. Materials are needed for both the destruction of weapon stockpiles and personal protection via fabric coatings or respirators. Attractive candidates for these applications include metal–organic frameworks (MOFs) – highly crystalline materials composed...
This dissertation is an ethnographic study of the dance makerspace, a learning environment designed to support STEM engagement through making and embodied experience for a group of African American youth dancers. It looks at how participants in a 4-week summer camp program at an urban creative arts center-turned-makerspace, constructed embodied...
This dissertation is a history of religious conservatism between 1880 and the onset of the Great Depression in 1929. Its main argument is that conservative religion in America, rather than being defined by fundamentalism, theological disputes, or cultural antipathy towards pluralism, was an outgrowth of a profound faith in capitalism...
While the entire silicon industry has been blooming under Moore’s Law for decades, conventional digital implementation is approaching the “stall” of Moore’s Law due to many physical design limitations. Technology innovation now is going to take a different direction. Given the increasing demand for emerging applications' computational capacity, it is...
Self-Assembled Monolayers for MALDI-TOF Mass Spectrometry (SAMDI-MS) is a technique that combines self-assembling molecules of alkane disulfides on gold and MALDI-TOF mass spectrometry. By using well-defined monolayers with functionalizations that both prevent non-specific adsorption onto the surface and presents immobilization handles, it is possible to pull out analytes of interest,...
Despite prevention and treatment, substantial risk for cardiovascular disease(CVD) remains in the population and CVD has been the leading global cause-of-death in past years.While high-density lipoprotein (HDL) markers such as HDL cholesterol (HDL-C) and HDL efflux (a cholesterol-transport-function assay) are associated with decreased risk of CVD, the mechanism of this...
The leptonic and inclusive hadronic decay branching fractions of the W boson are studied using 35.9 $fb^{-1}$ of proton-proton collision data collected at $\sqrt{s}=13~TeV$ during the 2016 run of the CMS experiment. Events characterized by the production of pairs of W bosons from \ttbar and \tW processes are selected. Multiple...
Extensive study of nanomaterial chemical and optical properties has enabled their integration into a variety of applications. However, less thoroughly investigated are the heat generation and dissipation processes of nanomaterials following optical excitation. These phenomena are of immense importance as thermal energy can distort a material’s structure, which has profound...
This dissertation combines perspectives from social networks and teams research to advance understanding of team self-assembly. Across three substantive chapters, I explore team member search behaviors and invitation patterns in contexts where individuals exercise agency to select team members. First, I consider the search for team members in a social...
As technology scales down, challenges in fabrication, thermal stress, and in-field degradation have put the reliability of processors at risk. Among different fault types, transient faults manifest themselves frequently due to high chip density, aggressive voltage scaling, and high clock frequency. Some dependable processor architectures have been proposed to counter...
Humans have a remarkable ability to create stable walking patterns that can resist and recover from perturbations. Unfortunately, this ability is substantially impaired after a stroke, limiting mobility and contributing to a high fall rate. To facilitate gait training during post-stroke rehabilitation, clinicians often incorporate body-weight support (BWS) systems that...
Sexual orientation is conventionally understood as relative attraction to men versus women. It has recently been argued that male sexual orientation in particular can be extended to include other dimensions of sexual attraction besides gender, such as sexual maturity and location. With respect to the dimension of location, most men...
In this dissertation, we study different machine learning algorithms including probabilistic, sparse and deep learning based models applied to multi-sensory datasets. In many machine learning problems, samples are collected from more than one source or modality. Also, various feature extraction methods can be used to provide more than one set...
In this thesis, I present the development and benchmarking of several theoretical methods designed to enable the rigorous modeling of magnetic properties of molecules containing one or a few heavy atoms, particularly single-molecule magnets. The new methods use a full four-component treatment of relativity, allowing spin–orbit effects to be taken...
Complex fluids are ubiquitous, from natural materials to manufactured products. Understanding their behavior under flow is vital for engineering these materials. Extensional flow, despite being industrially relevant and often producing dominant impacts upon complex fluids, is an underserved topic compared to shear flow due to a lack of reliable apparatuses...
This dissertation explores the poetry and culture of the late-Soviet era of Stagnation (1964-1985) through a broadly conceived cultural metaphor of stagnation. The five Russian poets and one American poet in this study- Viktor Krivulin, Alexei Parshchikov, Aleksandr Eremenko, Ivan Zhdanov, Elena Shvarts, and Lyn Hejinian- each engage with a...
This dissertation addresses inter alia the problem of certain intertextual discontinuities across Thomas Hobbes’s oeuvre regarding the issue of ecclesiology. I find that these disparities did not result from a change in Hobbes’s private opinions, but from the regicide of 1649 as an event that liberated Hobbes to unveil his...
Given directives such as the UN Global Goals targeting sustainable development, the research presented herein makes but a small contribution to the advancement of alternative energy technologies. Nevertheless, the present work was largely motivated to address specific points of intrigue within the thermoelectrics community. The general principles demonstrated, however, may...
Does the Russian Federation in the Putin-Medvedev era follow a grand strategy, and if so, what does it look like, and how can we discern the making of Russian grand strategy? However, Russian grand strategy is neither formally codified nor readily accessible, and it remains opaque at best. In this...
Friction modulation technology developed over the past decade now enables the creation of rich textural effects on flat haptic displays. However, an intuitive and manageably small design space for construction of such haptic textures remains an unfulfilled goal for user interface designers. In this thesis, I explore perceptually relevant features...
Although there has been profound evidence showing the positive correlation between spatial abilities and math performances, we still know very little about how and why spatial thinking facilitates the learning of mathematics. This dissertation unpacks several aspects of mathematics that are embedded in learning and playing an ancient and rich...
Mobile internet has brought a disruptive innovation to the ride-hail industry. The technology introduced by Uber, referred to as e-hail, matches passengers with drivers through their smart phones, while integrating transaction and feedback in a single app. In comparison to taxis hailed off street, or street-hail (s-hail hereafter), e-hail has...
In the past decade, the e-hail service provided by transportation network companies (TNCs) gained popularity in major cities around the world. By allowing passengers to virtually “hail” vehicles on mobile phones, e-hail has revolutionized the matching process in ride-hail, drastically reducing the existing search friction. However, previous studies found the...
Search engines and social media are two ubiquitous modes of accessing Web information, and they dictate what information people view, influencing their thoughts and beliefs and potentially shaping their opinions about news and facts. Network effects propagate the beliefs, often magnified, disseminating information rapidly and leaving little time for fact...
In machine learning, classification that assigns a label to a sample is a fundamental problem and serves a building block for various applications of artificial intelligence such as speech recognition, sentimental analysis, and image recognition. During the last years, deep learning rejuvenates artificial intelligence; in particular, it leads to tremendous...
Optical coherence tomography (OCT) is a high-resolution, non-contact, three-dimensional imaging technique, which has revolutionized the diagnosis and treatment of retinal diseases. Visible-light OCT (vis-OCT) extends OCT by enabling retinal oximetry – the measurement of oxygen saturation of hemoglobin from within individual retinal blood vessels. Three advances in the vis-OCT technique...
The highly flexible nature of 2D materials has led to them becoming fundamental building blocks for achieving novel device physics and potential breakthroughs in practical technologies. 2D layers can be interfaced in a wide array of methods with themselves, other 2D layered materials, or materials of entirely different type or...
Sequential batches of time-evolving data for a set of persistent identifiable entities (e.g. online shopping behavior by month for a customer ID, or economic figures by year for a collection of countries) can exhibit temporal shifts in their underlying clustering structure. Methods for recovering this evolutionary clustering structure exploit natural...
Circuit-level Dynamic Timing Slack (DTS) has emerged as a compelling opportunity for eliminating inefficiency in modern low-power systems. This slack arises when all the signals have propagated through logic paths well in advance of the clock signal. When it is properly identified, the system can exploit this unused cycle time...
Two major areas of research in the field of manufacturing are miniaturization and 3D printing. The trend towards miniaturization stems from the desire and need for additional functionality and improved performance for products with ever-smaller footprints. Miniaturization opens manufacturing to new applications such as tissue engineering and surface texturing. Meanwhile,...
Movement is achieved by combining synaptic inputs from various sources and activating motor unit populations. Motor units are the quantal elements of motor control which act as a neuromechanical transducer that converts sensory inputs into motor output. Because of the tight neuromuscular junctions between motoneuron axon terminals and a large...
The hippocampus has been identified as a critical structure for supporting spatial memory processes in both humans and animals alike. Many of these processes such as the ability to self-localize in a given environment as well as engage in goal-directed navigation are thought to depend on the location-specific firing of...
This dissertation studies topics in health care operations management related to value-based care, where {\em value} can be thought of as the ratio of quality to cost. The objective in value-based care is to increase, or maximize, value by reducing costs and improving quality health outcomes. In Chapter 1 we...
In this thesis, we study the homological mirror symmetry for the Gross-Siebert program of local mirror symmetry. We construct a pair of mirror objects by lifting a tropical curve in the integral tropical manifold of the Gross-Siebert program. Furthermore, we evaluate the central charges of the mirror objects and show...
It is said across numerous disciplines, from biology to architecture to software engineering, that “form ever follows function.” This adage highlights the intimate relationship between structural characteristics and functional properties in many disparate fields of work. Here, we discuss how the catalytic activity and compressibility of metal–organic frameworks (MOFs) are...
In conventional data federations, a set of data providers each possess an autonomous database and collectively make the union of these databases available for querying by a client from a unified SQL interface. This setting however, provides no guarantees on data privacy or security. With my work, I consider a...
Excess loading of reactive nitrogen and phosphorus into the environment from human activities has resulted in widespread eutrophication and the degradation of surface water quality and wildlife habitat. Wastewater is the dominant point source of nutrient loading into waterways, and thus represents a critical opportunity for treatment and prevention of...
This dissertation contains three chapters. In Chapter 1, I study the effects of bank leverage ratio restrictions in a general equilibrium model of the macroeconomy where lenders can anticipate bank runs. This framework allows the analysis of the tradeoffs associated with bank capital requirements - while unlimited leverage allows capital...
Protein homeostasis, or proteostasis, is essential for preserving all cellular functions and involves a balance of protein synthesis, folding, trafficking, and degradation. A collapse in proteostasis is a common feature of many neurodegenerative disorders that are characterized by the accumulation of insoluble protein aggregates in the brain. Parkinson’s disease (PD)...
Natural Language Processing methods have become increasingly important for a variety of high- and low-level tasks including speech recognition, question answering, and automatic language translation. The state of the art performance of these methods is continuously advancing, but reliance on labeled training data sets often creates an artificial upper bound...
Hybrid Organic-inorganic halide perovskites are emerging semiconducting materials that have shown over 23% in power conversion efficiency (PCE) for solar cells. The most prominent materials, three-dimensional (3D) perovskites, have limited scope for structural engineering and exhibit instability when encounter with moisture and heat. Here, we focus on studying the structure-property...
The active participation of external entities in the design and manufacturing flow has produced numerous hardware security issues. Among all the hardware security problems, piracy and overproduction are likely to be the most ubiquitous and expensive ones. Most leading-edge design houses have outsourced their fabrication to the offshore foundries for...
This dissertation project uses both quantitative and qualitative analytical approaches to examine the dynamics of responsible investing in financial markets. The first chapter investigates how the institutionalization of responsible investing as a business strategy affects category claims made by mutual funds. The study finds that as the divestment movement in...
Spin-orbit coupling (SOC) is a powerful phenomenon that dictates the functional properties of transition metal complexes essential for information processing, catalysis, and magnetism. Though it is relegated to lower energy scales within the orbital description of first-row transition metal complexes, SOC impacts crucial aspects of electronic structure such as promoting...
Introduction: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction associated with reduced quality of life, increased rates of depression and anxiety, and high economic burden to society and the individual. Current behavioral interventions, which target well-known symptom exacerbating factors such as catastrophizing and gastrointestinal- specific anxiety, have demonstrated...
With the growing size of networks and datasets and the lack of centralized access to information, distributed control and optimization become inevitable. In the first part of this thesis, we develop an asynchronous Newton-based distributed optimization algorithm and analyze its convergence properties. Our algorithm benefits from the fast convergence properties...
Receptor for activated C kinase 1 (RACK1) is a core small (40S) ribosomal subunit protein whose structure is highly conserved among eukaryotes apart from a C-terminal extended loop. We previously showed that a poxvirus kinase phosphorylates this flexible loop in human RACK1, mimicking endogenous negative charge in plant RACK1 to...
Self-assembly of colloidal particles at the nano- and microscale has been a powerful tool for producing structures with emergent properties in applications ranging from electro-mechanical systems to photonics and biomedical devices. Great success has been achieved in experiments, where a variety of exotic phases have been discovered and even reconfigurable...
New neurons are continuously produced in the subgranular zone of the dentate gyrus of the hippocampus throughout life. These newborn dentate granule cells (DGCs) undergo a stereotyped process of morphological and functional maturation during the first few weeks after differentiation that recapitulates some aspects of postnatal neuronal development. The inhibitory...
Metal–organic frameworks (MOFs) are a class of crystalline materials composed of metal nodes connected by organic linkers. Due to their high degree of synthetic tunability, MOFs have been considered for a wide range of applications, including many that rely on a change in oxidation state. While most MOFs are generally...
This thesis forcuses on the development of the transition-edge sensor (TES) for various X-ray science applications, especially for synchrotron beamline experiments. The ultimate aim is to build a detector that has a higher energy resolution than semiconductor detectors, and a higher operation speed than crystal spectrometers. The possible applications include...
This dissertation is composed by three chapters. Chapter one is about productivity hysterisis in the U.S. after the Great Recession. The United States has been experiencing a slowdown in productivity growth for more than a decade. I exploit geographic variation across U.S. Metropolitan Statistical Areas (MSAs) to investigate the link...
Selective attention enables people to focus on a small number of objects, features, or events with good resolution. Sometimes attention may also be less selective and distributed across numerous items, which allows more information to be processed at a lower resolution. The degree to which attention is more or less...
Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique that can detect single molecules and simultaneously obtain structural information. When an analyte molecule binds to a nanostructured noble metal surface, the otherwise weak normal Raman signal is enhanced by as much as a factor of 108. This makes SERS the...
Lasers and optical resonators have been widely utilized in precision metrological devices, such as gyroscopes, accelerometers, and gravitational wave detectors. To meet the requirements for a variety of applications, both of the slow light effect and the fast light effect have been applied to the lasers and optical resonators to...
