Investigating the drug response at the transcriptional level is powerful for understanding the mechanism of drug adverse effects, elucidating inter-individual drug response variability and developing personalized therapies. However, drug perturbation experiments are limited to immortal cell lines which do not reflect the true physiology and gene expression of the liver,...
The sexual network topology of individuals and their communities may affect the spread of infectious disease both within and across specific populations. To better understand this process, we collected ego-centric data on the personal sexual networks of 175 young men who have sex with men. Respondents were asked to nominate...
Objectives: Poor infant health is associated with lower wellbeing later in life. Food insecurity has been associated with higher rates of some morbidities in young children. However, this relationship has not been well studied in infants younger than six months or in Kenya. Thus, we sought to determine the relationship...
Numerical simulations have shown that black holes (BHs) have significant influence on the evolution of globular clusters (GCs), and therefore shape their observational features. Recently, a BH-main sequence star (MS) binary system has been observed in the Milky Way GC NGC 3201. Our group uses Cluster Monte Carlo (CMC) code...
The advent of next-generation sequencing has made it increasingly feasible to survey microbes in situ, including inside buildings where many people spend extended periods of time. Microbes in buildings, and specifically in dust, are linked to various health outcomes, and the amount of antimicrobial chemicals in dust is associated to...
Air pollution increases mortality risk up to 18 percent due to cardiovascular causes. Poor air quality occurs more when meteorological components prevent the dispersal of pollutants in the lower atmosphere. The atmospheric and hydrological patterns change as global warming alters the pattern of circulations seasonally. The purpose of this study...
Recent discoveries of black hole (BH) candidates in galactic and extragalactic globular clusters (GCs) have ignited interest in understanding how BHs dynamically evolve in a GC and the number of BHs (NBH) that may still be retained by today's GCs. Numerical models show that even if stellar-mass BHs are retained...
There are few concerns greater than those of a parent with an adult with an intellectual or developmental disability (I/DD). How is she or he going to be taken care of as she or he ages? The government provides services and support in the pursuit of care and services, but...
Due to their ability to be engineered for specific cellular targeting, nanoparticles (NPs) have emerged as promising drug delivery vessels for immunotherapeutic and vaccination treatments. However, a major unsolved obstacle for cell-specific nanoparticle delivery is non-specific circulatory clearance by the mononuclear-phagocytic system(MPS). Comprised of various phagocytic cells, the MPS removes...
Physiological linkage (i.e., the covariation of moment-to-moment physiology between individuals) is thought to play an important role in relationship functioning. The present study examined physiological linkage across interbeat interval (IBI) and skin conductance levels (SCL) in a sample of married spouses (N=106) during both a pleasant and a conflict conversation...