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Description:: Circadian rhythms — physiological, behavioral, and metabolic oscillations with an approximate 24-h period — are controlled by an evolutionarily conserved set of core clock genes operating at the transcriptional and protein level. Entrainable by Zeitgebers (external environmental stimuli such as light, temperature, and food) that modulate time-of-day specific functions, the...
Keyword:: Differential Dynamics Detection, Time-Series Analysis, Dynamical Systems Theory, Circadian Rhythms, Topological Analysis, and Cycle Detection
Subject:: Biostatistics, Applied mathematics, and Bioinformatics
Creator:: Ness-Cohn, Elan Meir
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_875611 and http://dissertations.umi.com/northwestern:15905

Description:: Modern data sets are increasingly vast, not only in the number of samples, but also in the number of measurements, or features, that they contain. This high-dimensionality poses a unique set of problems for data analysis due to a set of phenomena known as ``the curse of dimensionality.'' This thesis...
Keyword:: Data Visualization, Circular Linear Regression, Dimensionality Reduction, Curse of Dimensionality, and Quality Assessment
Subject:: Applied mathematics, Bioinformatics, and Computer science
Creator:: Johnson, Eric Mitchell
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_892588 and http://dissertations.umi.com/northwestern:15988

Description:: Gene regulatory networks (GRNs) are important abstractions of the complex regulatory interplays between genes, proteins, metabolites, and other molecular-level entities. Comprehensive GRNs provide high-level overviews of the topology of gene-gene interactions and their purposes, thereby enabling a comprehensive understanding of their role in phenotypic variation, disease mechanisms, and other biological...
Subject:: Applied mathematics and Bioinformatics
Creator:: Nguyen, Phan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14495 and etdadmin_upload_634566

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