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Description:: SAMDI-MS (Self-Assembled Monolayers for MALDI-TOF Mass Spectrometry) couples the use of chemically-defined self-assembled monolayers of alkane thiolates on gold surfaces with MALDI-TOF mass spectrometry for rapid characterization of the surfaces. Reactions performed on the surfaces can be quantified directly by detection of the reaction substrates and products. This rapid detection...
Keyword:: SAMDI, mass spectrometry, bioassay, chromodomains, cell-free reactions, and microfluidics
Subject:: Analytical chemistry, Materials Science, and Biochemistry
Creator:: O'Kane, Patrick Thomas
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14615 and etdadmin_upload_661860

Description:: Epigenetics is the study of chromatin-based events that regulate gene expression without the change of DNA sequence, including DNA methylation, histone modification and chromatin remodeling. Epigenetic regulators are encoded to modify chromatin in a highly regulated and dynamic manner. A growing number of studies have suggested the dysregulation of epigenetic...
Keyword:: Biological sciences, Histone methylation, Proteomics, Mass spectrometry, Protein interaction, and Epigenetics
Subject:: Analytical chemistry, Molecular biology, and Biochemistry
Creator:: Huang, Xiaoxiao
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_686355 and http://dissertations.umi.com/northwestern:14838

Description:: More than half of proteins in humans are modified with carbohydrates in a process called glycosylation, yet this process remains poorly understood even though approximately 1% of the expressed human genome encodes biosynthetic machinery for glycosylation. Unlike genomics and proteomics where high throughput tools are now routinely used to generate...
Keyword:: SAMDI, High-throughput protein synthesis, glycosylation, self-assembled monolayers, glycosyltransferase, and Mass spectrometry
Subject:: Bioengineering, Analytical chemistry, and Biochemistry
Creator:: Techner, Jose-Marc
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14598 and etdadmin_upload_661107

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