Index Catalog // Arch : Northwestern University Institutional Repository

Dynamic Mechanisms of Metabotropic Glutamate Receptor Activation and Modulation

Description:: G protein-coupled receptors (GPCRs) are the largest family of membrane receptors in humans and play a role in nearly all physiological processes. Among GPCRs, metabotropic glutamate receptors (mGluRs) are a structurally distinct family of synaptic receptors that are essential in regulating neurotransmission and synaptic plasticity. Due to their important regulatory...
Keyword:: structural dynamics, mGluRs, conformational dynamics, membrane proteins, smFRET, and GPCRs
Subject:: Pharmacology, Biochemistry, and Biophysics
Creator:: Liauw, Brandon Wey-Hung
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_937523 and http://dissertations.umi.com/northwestern:16310

The Mechanism of Activation and Sensitivity-Tuning of the Calcium-Sensing Receptor

Description:: Transfer of information across membranes is fundamental to the function of all organisms and is primarily initiated by transmembrane receptors. This is an allosteric process and involves conformational coupling between ligand-binding domain and signaling domain of a receptor. This allosteric mechanism of activation is unclear for many receptors. Moreover, for...
Keyword:: GPCR, CaSR, and smFRET
Subject:: Bioinformatics, Biochemistry, and Biophysics
Creator:: Schamber, Michael Robert
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 09/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16268 and etdadmin_upload_929368

Mechanistic Insights into Coactivator Recruitment by Nuclear Receptors

Description:: Nuclear receptors (NRs) are an important family of transcription factors that often regulate genes in response to ligands and by way of direct interactions with coactivator proteins. Many NR-coactivator pairs have been identified that cooperate to regulate transcription but fully understanding how NRs recruit specific coactivators involves learning which of...
Keyword:: Transcriptional Regulation, NMR, and Nuclear Receptors
Subject:: Biology, Biochemistry, and Biophysics
Creator:: Daffern, Nicolas
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 09/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16121 and etdadmin_upload_910580

Structural Studies of Particulate Methane Monooxygenase in a Native Lipid Bilayer

Description:: Methanotrophs, bacteria that can metabolize methane, remain a promising solution to mitigating the effects of climate change by removing atmospheric methane and converting it to useful chemical precursors. However, a full understanding of the main enzyme they use to oxidize methane, particulate methane monooxygenase (pMMO), is critical for harnessing their...
Keyword:: cryogenic electron tomography, particulate methane monooxygenase, membrane protein, cryogenic electron microscopy, and cell-free protein synthesis
Subject:: Molecular biology, Biochemistry, and Biophysics
Creator:: Koo, Christopher Wellington
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_897671 and http://dissertations.umi.com/northwestern:16003

Structural Visualization of State Transition during Non-Homologous End-Joining (NHEJ)

Description:: DNA double-strand breaks (DSBs) are caused by either endogenous agents or exogenous ionizing radiation and chemicals. Incorrect DSB repair can lead to undesired genome rearrangements. Homologous recombination (HR) and non-homologous end-joining (NHEJ) pathways are two major DNA repair pathways that repair DSBs and maintain genome integrity. When homologous DNA is...
Keyword:: DNA repair, Cryo EM, NHEJ, DNA-PKcs, Cancer, and CRISPR
Subject:: Molecular biology, Biochemistry, and Biophysics
Creator:: Chen, Siyu
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_879511 and http://dissertations.umi.com/northwestern:15936

Structural Investigation of Chromatin Regulatory Complexes Using Electron Microscopy

Description:: Eukaryotic genomes are organized into chromatin, which acts to regulate access to the organism’s genetic material. A large and diverse class of proteins, known as chromatin modifiers and remodelers, are responsible for regulating the composition and structure of chromatin by monitoring nucleosomes. Chromatin remodelers are involved in multiple cellular processes,...
Subject:: Biology, Biochemistry, and Biophysics
Creator:: Reyes, Alexis Amaris
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15930 and etdadmin_upload_879245

Cobalt (III) Schiff-base Complexes as Inhibitors of Pathogenic Metalloproteins

Description:: Cobalt(III) Schiff-base complexes (Co(III)-sb) have been utilized in the literature as antibacterial, antiviral, and inhibitory agents. Recent work has utilized their ability to displace endogenous metals from metalloproteins that exhibit aberrant gain of function pathologies in human disease. Specifically, in this dissertation Co(III)-sb has been applied as inhibitors of pathogenic...
Keyword:: Transcription Factors, Coordination Complexes, Cobalt, Amyloid-beta, Molecular Dynamics, and Intrinsically Disordered Proteins
Subject:: Chemistry, Biochemistry, and Biophysics
Creator:: Brue, Christopher Robert
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/02/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15862 and etdadmin_upload_863221

Cryogenic-Electron Microscopy Structures of Viral and Eukaryotic Transcription Complexes

Description:: Transcription of nucleic acids (DNA and RNA) is a hallmark of life, taking the information stored within genomic nucleic acids and converting it into a form that is useful for producing the proteins necessary for cellular and organismal function. In eukaryotes, transcription of DNA into messenger RNA (mRNA) requires the...
Keyword:: Virology, Paramyxovirus, Cryo-EM, Mediator, Polymerase, and Transcription
Subject:: Molecular biology, Biochemistry, and Biophysics
Creator:: Abdella, Ryan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 04/15/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15490 and etdadmin_upload_797897

Structural Studies of the Type III-A CRISPR Effector Complex in Staphylococcus epidermidis RP62a

Description:: Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated Cas proteins provide an immune-like response in many prokaryotes against extraneous nucleic acids. CRISPR-Cas systems are classified into different classes and types that vary widely in composition, target recognition, and overall mechanism. The main division of CRISPR-Cas systems occurs between...
Keyword:: Staphylococcus epidermidis, X-ray crystallography, Cryo-EM, Csm3, CRISPR, and Csm2
Subject:: Molecular biology, Biochemistry, and Biophysics
Creator:: Dorsey, Bryan William
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_655609 and http://dissertations.umi.com/northwestern:14567

LIBRARIES | ARCH

Limit your search

Type

Resource type

Creator

Keyword

Subject

Language

Dynamic Mechanisms of Metabotropic Glutamate Receptor Activation and Modulation

The Mechanism of Activation and Sensitivity-Tuning of the Calcium-Sensing Receptor

Mechanistic Insights into Coactivator Recruitment by Nuclear Receptors

Structural Studies of Particulate Methane Monooxygenase in a Native Lipid Bilayer

Structural Visualization of State Transition during Non-Homologous End-Joining (NHEJ)

Structural Investigation of Chromatin Regulatory Complexes Using Electron Microscopy

Cobalt (III) Schiff-base Complexes as Inhibitors of Pathogenic Metalloproteins

Cryogenic-Electron Microscopy Structures of Viral and Eukaryotic Transcription Complexes

Structural Studies of the Type III-A CRISPR Effector Complex in Staphylococcus epidermidis RP62a

Limit your search

Search Constraints

Search Results