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UBR7 Acts as a Histone Chaperone That Promotes Reincorporation of Post-Nucleosomal Histone H3

Description:

The eukaryotic genome is packaged into chromatin. The nucleosome, the basic unit of chromatin, is composed of DNA coiled around a histone octamer. Histones are among the longest-lived protein species in mammalian cells, due to their thermodynamic stability and their associations with DNA and histone chaperones. Histone metabolism plays an...

Keyword:

UBR7, NASP, histone, H3, chaperone, and chromatin

Subject:

Biology, Biochemistry, and Genetics

Creator:

Ferguson, Ann

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15808 and etdadmin_upload_853746
Uncovering modifiers of cardiomyopathy in the noncoding genome

Description:

Heart failure due to genetic cardiomyopathy is associated with a range of phenotypic expression. The studies in this body of work interrogated the role of noncoding variation in modifying cardiomyopathy phenotypes. We used cap analysis of gene expression in heathy and failed left ventricles to define the regulatory environment of...

Keyword:

noncoding, genetics, MYH7, heart failure, modifier, and enhancer

Subject:

Molecular biology, Genetics, and Biochemistry

Creator:

Gacita, Anthony Martin

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_756135 and http://dissertations.umi.com/northwestern:15193

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UBR7 Acts as a Histone Chaperone That Promotes Reincorporation of Post-Nucleosomal Histone H3

Uncovering modifiers of cardiomyopathy in the noncoding genome

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