Limit your search
- Biochemistry[remove]41
- Molecular biology15
- Biology12
- Biophysics9
- Bioengineering5
- more Subjects »
Search Constraints
« Previous |
1 - 20 of 41
|
Next »
Number of results to display per page
Search Results
-
- Description:
- Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed in the heart and central nervous system where they regulate membrane excitability. Recently, inhibiting HCN channels in the hippocampus has been identified as a possible therapeutic intervention for the treatment of Major Depressive Disorder (MDD). However, based on the high expression level of...
- Keyword:
- HCN, OPC, Oligodendrocyte, TRIP8b, and Depression
- Subject:
- Neuroscience, Biochemistry, and Developmental Biology
- Creator:
- Kyle Andrew Lyman
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 06/17/2019
- Date Modified:
- 06/17/2019
- Date Created:
- 2016-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- https://doi.org/10.21985/N2W781
-
- Description:
- Proteins represent a critical class of biomolecules, universally employed by all living organisms to fulfill essential structural, functional, and enzymatic roles necessary to support life. In nature, these polymers are composed generally of twenty natural amino acid (AA) building blocks, which can be modified with covalent adducts known as post-translational...
- Keyword:
- post-translational modification, genome engineering, cell-free protein synthesis, synthetic biology, orthogonal translation system, and non-canonical amino acid
- Subject:
- Bioengineering, Biology, and Biochemistry
- Creator:
- Des Soye, Benjamin James
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14473 and etdadmin_upload_627384
-
- Description:
- Methylation of histone 3 lysine 4 (H3K4) catalyzed by the COMPASS family of lysine methyltransferases is universally associated with eukaryotic transcription. However, despite thousands of published studies examining the deposition, dynamics, and genomic positions of this chromatin modification, there is no clear consensus as to the molecular function or biological...
- Subject:
- Biochemistry
- Creator:
- Rickels, Ryan A
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14787 and etdadmin_upload_682860
-
- Description:
- This work combines the use of high-throughput mass spectrometry with peptide arrays for to monitor reactions on peptides. The Mrksich lab introduced a high-throughput, label-free, biochemical assay that relies on self-assembled monolayers on gold and matrix-assisted laser desorption/ionization mass spectrometry, termed SAMDI-MS. This dissertation introduces new applications of SAMDI-MS and...
- Keyword:
- High-throughput, SAMDI, Phosphatase, Mass spectrometry, and Peptide Arrays
- Subject:
- Chemistry and Biochemistry
- Creator:
- Szymczak, Lindsey Catherine
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14701 and etdadmin_upload_667038
-
- Description:
- The work in this thesis focuses on computational methods for the identification of novel enzymatic pathways. In particular this work focuses on the utilization of the Biological Network Integrated Computational Explorer (BNICE) software suite to predict de novo enzymatic pathways for the production of commercially relevant compounds and on improvements...
- Subject:
- Bioengineering and Biochemistry
- Creator:
- Stine, Andrew Eugene
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2016-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_614431 and http://dissertations.umi.com/northwestern:14393
-
- Description:
- SAMDI-MS (Self-Assembled Monolayers for MALDI-TOF Mass Spectrometry) couples the use of chemically-defined self-assembled monolayers of alkane thiolates on gold surfaces with MALDI-TOF mass spectrometry for rapid characterization of the surfaces. Reactions performed on the surfaces can be quantified directly by detection of the reaction substrates and products. This rapid detection...
- Keyword:
- SAMDI, mass spectrometry, bioassay, chromodomains, cell-free reactions, and microfluidics
- Subject:
- Analytical chemistry, Materials Science, and Biochemistry
- Creator:
- O'Kane, Patrick Thomas
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14615 and etdadmin_upload_661860
-
- Description:
- Epigenetics is the study of chromatin-based events that regulate gene expression without the change of DNA sequence, including DNA methylation, histone modification and chromatin remodeling. Epigenetic regulators are encoded to modify chromatin in a highly regulated and dynamic manner. A growing number of studies have suggested the dysregulation of epigenetic...
- Keyword:
- Biological sciences, Histone methylation, Proteomics, Mass spectrometry, Protein interaction, and Epigenetics
- Subject:
- Analytical chemistry, Molecular biology, and Biochemistry
- Creator:
- Huang, Xiaoxiao
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_686355 and http://dissertations.umi.com/northwestern:14838
-
- Description:
- More than half of proteins in humans are modified with carbohydrates in a process called glycosylation, yet this process remains poorly understood even though approximately 1% of the expressed human genome encodes biosynthetic machinery for glycosylation. Unlike genomics and proteomics where high throughput tools are now routinely used to generate...
- Keyword:
- SAMDI, High-throughput protein synthesis, glycosylation, self-assembled monolayers, glycosyltransferase, and Mass spectrometry
- Subject:
- Bioengineering, Analytical chemistry, and Biochemistry
- Creator:
- Techner, Jose-Marc
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14598 and etdadmin_upload_661107
-
- Description:
- The literature has established glucokinase (GCK) to be the principal hexokinase (HK) in the liver, operating as a glucose sensor to regulate glucose metabolism and lipid homeostasis. We have recently proposed Hexokinase Domain Containing-1 (HKDC1) to be a novel 5th HK with expression in the liver. Here, we reveal HKDC1...
- Keyword:
- Hexokinase, NAFLD, Liver Metabolism, and HKDC1
- Subject:
- Molecular biology, Biology, and Biochemistry
- Creator:
- Pusec, Carolina
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14450 and etdadmin_upload_626205
-
- Description:
- One of the grand challenges in science is development of soft materials that mimic living organisms to optimize the way we use energy, translate or morph reversibly or sense their envi- ronment and respond in a useful fashion. Using the insights from studying biological structures, we hope to design soft...
- Subject:
- Materials Science, Biochemistry, and Computational chemistry
- Creator:
- Iscen, Aysenur
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14770 and etdadmin_upload_679718
-
- Description:
- Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated Cas proteins provide an immune-like response in many prokaryotes against extraneous nucleic acids. CRISPR-Cas systems are classified into different classes and types that vary widely in composition, target recognition, and overall mechanism. The main division of CRISPR-Cas systems occurs between...
- Keyword:
- Staphylococcus epidermidis, X-ray crystallography, Cryo-EM, Csm3, CRISPR, and Csm2
- Subject:
- Molecular biology, Biochemistry, and Biophysics
- Creator:
- Dorsey, Bryan William
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_655609 and http://dissertations.umi.com/northwestern:14567
-
- Description:
- Harnessing the metabolic potential of methanotrophic bacteria is a compelling strategy for the bioremediation of environmentally harmful methane gas. Methanotrophs can activate a 105 kcal/mol C-H bond in methane at ambient conditions using metalloenzymes called methane monooxygenases (MMOs). Particulate methane monooxygenase (pMMO) is a copper-dependent, membrane-bound enzyme that is the...
- Keyword:
- copper, methane, methanotroph, metalloenzyme, particulate methane monooxygenase, and membrane protein
- Subject:
- Microbiology, Chemistry, and Biochemistry
- Creator:
- Ro, Soo Yeon
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14705 and etdadmin_upload_667719
-
- Description:
- Nucleic acid drugs promise to revolutionize the development of therapeutics. They offer a platform for digital medicine, where systematic changes to the nucleic acid sequence can be utilized to target the entire human genome. However, nucleic acids suffer from a number of drawbacks, such as negligible cellular uptake and rapid...
- Keyword:
- siRNA, Spherical Nucleic Acids, and High Throughput Analysis
- Subject:
- Nanotechnology, Nanoscience, and Biochemistry
- Creator:
- Yamankurt, Gokay
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14982 and etdadmin_upload_717353
-
- Description:
- Natural products from fungi have had an immeasurable societal impact as both friends and foes to human health. This includes numerous therapeutics that have had widespread clinical success, mycotoxins that are implicated in fungal pathogenicity, and various agrochemicals. Recent genome sequencing efforts have revealed that fungal genomes contain the capacity...
- Subject:
- Biochemistry
- Creator:
- Robey, Matthew
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_731063 and http://dissertations.umi.com/northwestern:15039
-
- Description:
- The interaction of amyloid-β (Aβ) with endogenous metal ions is thought to play a role in the pathogenesis of Alzheimer’s disease (AD). However, limited tools exist to study and modulate Aβ-metal binding. The Meade lab has developed cobalt(III) Schiff base (Co(III)-sb) complexes as protein inhibitors that competitively displace metals from...
- Keyword:
- amyloid-beta, aggregation, cobalt(III) Schiff base, and coordination complex
- Subject:
- Biology, Biochemistry, and Neurosciences
- Creator:
- Roberts, Kaleigh Filisa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_773649 and http://dissertations.umi.com/northwestern:15349
-
- Description:
- Although centrosomes nucleate and organize microtubules in mitotically-dividing cells, spindles in female reproductive cells (oocytes) form in their absence. In some organisms acentrosomal spindle assembly is mediated by acentriolar microtubule organizing centers (MTOCs) that are thought to functionally replace centrosomes. However, spindle assembly in human oocytes does not require MTOCs;...
- Keyword:
- acentrosomal, meiosis, acentriolar, kinesin, microtubule, and C. elegans
- Subject:
- Molecular biology, Biochemistry, and Cellular biology
- Creator:
- Wolff, Ian
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_763687 and http://dissertations.umi.com/northwestern:15248
-
- Description:
- Heart failure due to genetic cardiomyopathy is associated with a range of phenotypic expression. The studies in this body of work interrogated the role of noncoding variation in modifying cardiomyopathy phenotypes. We used cap analysis of gene expression in heathy and failed left ventricles to define the regulatory environment of...
- Keyword:
- noncoding, genetics, MYH7, heart failure, modifier, and enhancer
- Subject:
- Molecular biology, Genetics, and Biochemistry
- Creator:
- Gacita, Anthony Martin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_756135 and http://dissertations.umi.com/northwestern:15193
-
- Description:
- Proper partitioning of mitochondria and mtDNA is critical for cellular health. Investigations into mitochondrial inheritance, specifically how mtDNA inheritance is coupled with the inheritance mitochondrial compartment, are still in the early stages. We use budding yeast as a model polarized cell system to study a mitochondrial Myo2-adaptor protein, Mmr1, in...
- Keyword:
- mitochondria, mitochondrial tethering, mtDNA, Mmr1, and mitochondrial inheritance
- Subject:
- Molecular biology, Biochemistry, and Cellular biology
- Creator:
- Chen, WeiTing
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_763646 and http://dissertations.umi.com/northwestern:15245
-
- Description:
- Melanin is a functional biopolymer most commonly associated with human skin pigmentation, where it serves as a radiation protection agent, shielding us from the harmful effects of UV radiation. However, melanin is also present in human ears, eyes, hair, and brains, serving a variety of functions. In fact, melanin...
- Keyword:
- porosity, toxin adsorption, nanoparticles, fungal, melanin, and radiation protection
- Subject:
- Materials Science and Biochemistry
- Creator:
- McCallum, Naneki C.
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15478 and etdadmin_upload_797429
-
- Description:
- Transcription of nucleic acids (DNA and RNA) is a hallmark of life, taking the information stored within genomic nucleic acids and converting it into a form that is useful for producing the proteins necessary for cellular and organismal function. In eukaryotes, transcription of DNA into messenger RNA (mRNA) requires the...
- Keyword:
- Virology, Paramyxovirus, Cryo-EM, Mediator, Polymerase, and Transcription
- Subject:
- Molecular biology, Biochemistry, and Biophysics
- Creator:
- Abdella, Ryan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15490 and etdadmin_upload_797897
- « Previous
- Next »
- 1
- 2
- 3