Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions – providing a powerful system to study prionization. Previously, the Li Lab demonstrated that Swi1, a component of the SWI/SNF chromatin-remodeling complex, can form the prion [SWI+]. A small region,...
Keyword:: [SWI+], yeast, protein aggregation, prions, Saccharomyces cerevisiae, and Swi1
Subject:: Molecular biology, Bioinformatics, and Neurosciences
Creator:: Goncharoff, Dustin Kenneth
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/28/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_816388 and http://dissertations.umi.com/northwestern:15538

Description:: Uterine leiomyomas (fibroids) are a major source of gynaecologic morbidity in reproductive age women and are characterised by the excessive deposition of a disorganised extracellular matrix, resulting in rigid benign tumours. Clinically, leiomyoma patients usually present with pelvic pain, urinary incontinence, as well as heavy cyclic and non-cyclic bleeding. Curative...
Subject:: Molecular biology, Bioinformatics, and Biology
Creator:: Moyo, Mthabisi Bongani
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_723828 and http://dissertations.umi.com/northwestern:15028

Description:: Uterine leiomyomas (fibroids) are a major source of gynaecologic morbidity in reproductive age women and are characterised by the excessive deposition of a disorganised extracellular matrix, resulting in rigid benign tumours. Clinically, leiomyoma patients usually present with pelvic pain, urinary incontinence, as well as heavy cyclic and non-cyclic bleeding. Curative...
Subject:: Molecular biology, Bioinformatics, and Biology
Creator:: Moyo, Mthabisi Bongani
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 01/21/2021
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_723828 and http://dissertations.umi.com/northwestern:15028

Description:: Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two devastating neurodegenerative diseases that affect 100,000s of people globally. They have a severe adverse impact on society, yet there are currently no early diagnostic tools or disease-modifying therapies available. Despite their clinical heterogeneity, evidence points to these diseases being on...
Keyword:: microRNA, Compositional Data Analysis, TDP-43 Proteinopathy, FUS Proteinopathy, RNA-Seq, and Mitochondria
Subject:: Molecular biology, Bioinformatics, and Neurosciences
Creator:: McGee, Warren A
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14675 and etdadmin_upload_663037

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