Index Catalog // Arch : Northwestern University Institutional Repository

Organoids model distinct vitamin E effects at different stages of prostate cancer evolution

Description:: Prostate cancer (PCa) is the most common non-cutaneous cancer among U.S. men. Lack of effective treatments for advanced disease make it a significant public health concern. However, PCa’s long natural history makes it an excellent target for prevention approaches that reduce overtreatment of indolent disease, treatment related morbidity, and mortality....
Keyword:: SELECT, Extracellular matrix, Prostate cancer, Reactive Oxygen Species, Organoids, and Fatty Acid Oxidation
Subject:: Molecular biology, Biology, and Cellular biology
Creator:: Njoroge, Rose Nyawira
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14428 and etdadmin_upload_623433

Requirement of the Caspase-3 Homologue DrICE in Drosophila Tracheal Size Control

Description:: Proper size control of organs and tissues is critical to their function, and it is necessary for the millions of precisely sized tubes that make up those organs— for example, excessive cell growth can lead to devastating diseases such as Polycystic Kidney Disease. The regulation of tube growth is therefore...
Keyword:: Trafficking, Non-apoptotic, Trachea, Caspase, and Apoptosis
Subject:: Molecular biology, Biology, and Cellular biology
Creator:: McSharry, Saoirse Susan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_661142 and http://dissertations.umi.com/northwestern:14599

A Conserved Mechanism for Mitochondrial Anchoring and Integrated Organelle Positioning

Description:: Inter-organelle contacts facilitate communication between organelles and impact fundamental cellular functions. Investigations into the molecular mechanisms of inter-organelle tethering are still in the early stages, and we are just beginning to appreciate the number and variety of inter-organelle tethers that exist. We have used budding yeast as a model polarized...
Keyword:: mitochondria and membrane contact sites
Subject:: Biology and Cellular biology
Creator:: Kraft, Lauren Michele
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_626904 and http://dissertations.umi.com/northwestern:14460

Human NKG2D Ligand Regulation of NK Cell Functions and Metabolism: From Molecular Mechanisms to Therapeutics

Description:: Natural Killer (NK) cell dysfunction is associated with poorer clinical outcome in cancer patients. What regulates NK cell dysfunction in tumor microenvironment is not well understood. NKG2D/NKG2DL pathway is very well recognized as an effective immune axis in tumor immunosurveillance. Abundant evidence from experimental preclinical animal models as well as...
Subject:: Biology, Cellular biology, and Immunology
Creator:: Dhar, Payal
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15682 and etdadmin_upload_839121

Foxp3-specific Deubiquitinase Modules enhance Treg fitness

Description:: Regulatory T (Treg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumor immunity. Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of proinflammatory properties, can promote autoimmunity and/or facilitate more effective tumor immunity. A comprehensive understanding...
Keyword:: Tumor, Treg, Ubiquitin, Foxp3, Usp21, and Usp22
Subject:: Biology, Cellular biology, and Immunology
Creator:: Montauti, Elena
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/02/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_846345 and http://dissertations.umi.com/northwestern:15780

CD81 Partners with CD44 in Promoting Exosome Integrity, Tumor Cell Cluster Formation, and Lung Metastasis in Triple Negative Breast Cancer

Description:: Tumor-initiating cells with reprogramming plasticity are thought to be essential for cancer development and metastatic regeneration in many cancers; however, the molecular mechanisms are not fully understood. We have previously identified that CD44, a breast tumor-initiating cell marker, drives mammosphere self-renewal and multicellular aggregation of circulating tumor cell (CTC) clusters,...
Keyword:: exosomes, CD44, cancer stem cells, extracellular vesicles, CD81, and breast cancer
Subject:: Molecular biology, Biology, and Cellular biology
Creator:: Ramos, Erika Kathryn
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16152 and etdadmin_upload_916551

Direct Reprogramming of Human Cells to a Cardiomyocyte-Like State

Description:: The reprogramming of somatic cells to a spontaneously contracting cardiomyocyte-like state using defined transcription factors has proven successful in mouse fibroblasts. However, this process has been less successful in human cells, thus limiting the potential clinical applicability of this technology in regenerative medicine. We hypothesized that this issue is due...
Keyword:: calcium cycling, spontaneous contraction, high-throughput, cardiomyocyte, direct reprogramming, and fibroblast
Subject:: Biology, Cellular biology, and Developmental biology
Creator:: Romero Tejeda, Marisol
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_970274 and http://dissertations.umi.com/northwestern:16446

Dissecting the stability determinants of a challenging de novo protein fold and assay development to identify cell-penetrating miniproteins

Description:: This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...
Keyword:: protein design, cell-penetrating protein, protein folding stability, and synthetic biology
Subject:: Biology, Cellular biology, and Biophysics
Creator:: Kim, Tae-Eun
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 08/23/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_1008136 and http://dissertations.umi.com/northwestern:16683

Dissecting the stability determinants of a challenging de novo protein fold and assay development to identify cell-penetrating miniproteins

Description:: This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...
Keyword:: protein design, cell-penetrating protein, synthetic biology, and protein folding stability
Subject:: Biology, Cellular biology, and Biophysics
Creator:: Kim, Tae-Eun
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 08/23/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16695 and etdadmin_upload_1009800

LIBRARIES | ARCH

Limit your search

Type

Resource type

Creator

Keyword

Subject

Language

Organoids model distinct vitamin E effects at different stages of prostate cancer evolution

Requirement of the Caspase-3 Homologue DrICE in Drosophila Tracheal Size Control

A Conserved Mechanism for Mitochondrial Anchoring and Integrated Organelle Positioning

Human NKG2D Ligand Regulation of NK Cell Functions and Metabolism: From Molecular Mechanisms to Therapeutics

Foxp3-specific Deubiquitinase Modules enhance Treg fitness

CD81 Partners with CD44 in Promoting Exosome Integrity, Tumor Cell Cluster Formation, and Lung Metastasis in Triple Negative Breast Cancer

Direct Reprogramming of Human Cells to a Cardiomyocyte-Like State

Dissecting the stability determinants of a challenging de novo protein fold and assay development to identify cell-penetrating miniproteins

Dissecting the stability determinants of a challenging de novo protein fold and assay development to identify cell-penetrating miniproteins

Limit your search

Search Constraints

Search Results