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Description:: The opposing activities of phosphatases and kinases determine the phosphorylation status of proteins, yet kinases have received disproportionate attention in studies of cellular processes, with the roles of phosphatases remaining less understood. This dissertation describes the use of self-assembled monolayer laser desorption/ionization mass spectrometry (SAMDI-MS) together with peptide arrays to...
Keyword:: SAMDI-MS, Phosphatases, High-Throughput Experiments, Enzyme Specificity, β-Catenin, and Peptide Arrays
Subject:: Chemistry, Biochemistry, and Cellular biology
Creator:: Huang, Che-Fan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/28/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_819016 and http://dissertations.umi.com/northwestern:15570

Description:: Although centrosomes nucleate and organize microtubules in mitotically-dividing cells, spindles in female reproductive cells (oocytes) form in their absence. In some organisms acentrosomal spindle assembly is mediated by acentriolar microtubule organizing centers (MTOCs) that are thought to functionally replace centrosomes. However, spindle assembly in human oocytes does not require MTOCs;...
Keyword:: acentrosomal, meiosis, acentriolar, kinesin, microtubule, and C. elegans
Subject:: Molecular biology, Biochemistry, and Cellular biology
Creator:: Wolff, Ian
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_763687 and http://dissertations.umi.com/northwestern:15248

Description:: Proper partitioning of mitochondria and mtDNA is critical for cellular health. Investigations into mitochondrial inheritance, specifically how mtDNA inheritance is coupled with the inheritance mitochondrial compartment, are still in the early stages. We use budding yeast as a model polarized cell system to study a mitochondrial Myo2-adaptor protein, Mmr1, in...
Keyword:: mitochondria, mitochondrial tethering, mtDNA, Mmr1, and mitochondrial inheritance
Subject:: Molecular biology, Biochemistry, and Cellular biology
Creator:: Chen, WeiTing
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_763646 and http://dissertations.umi.com/northwestern:15245

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