Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus in these anatomical compartments and how and when the virus reaches those sites. To...
Subject:: Virology, Cellular biology, and Immunology
Creator:: Madden, Patrick
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15987 and etdadmin_upload_892041

Description:: RNA viruses cause a wide range of diseases that range from mild respiratory illness to fatal hemorrhagic fevers. To combat these pathogens, most cells in the human body scan the cell for viruses and activate a potent cell-intrinsic immune response by producing interferon (IFN), a cytokine that amplifies the innate...
Subject:: Virology, Molecular biology, and Cellular biology
Creator:: Lenoir, Jessica
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_866862 and http://dissertations.umi.com/northwestern:15886

Description:: The microtubule (MT) network and associated regulatory proteins play a critical role during viral infection from facilitating viral particle transport towards the nucleus upon entry to later mediating virion assembly and egress. Many of the precise mechanisms by which viruses commandeer the host MT network to propagate infection remain poorly...
Keyword:: TACC3, virus, microtubules, and +TIP
Subject:: Virology, Microbiology, and Cellular biology
Creator:: Furey, Colleen Patricia
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/02/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_856328 and http://dissertations.umi.com/northwestern:15823

Description:: Type I interferon (IFN) is the primary antiviral cytokine establishing a broad and potent antiviral response to protect mammalian cells from virus infection. The functional repertoire of IFN extends to innate and adaptive immunity, neoplastic transformation, resistance and cancer immunotherapy. IFN functions are primarily mediated through the Janus kinase (JAK)...
Keyword:: ISGF3, Interferon, Chromatin, Antiviral, ISG, and H2A.Z
Subject:: Virology, Molecular biology, and Cellular biology
Creator:: Au Yeung, Weng Si (Nancy)
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_618020 and http://dissertations.umi.com/northwestern:14409

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