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-
- Description:
- Promyelocytic leukemia (PML) nuclear bodies act as quality control centers in the nucleus, participating in a plethora of nuclear functions. As such, PML bodies are a signature model for functional nuclear organization. PML bodies have a dynamic protein composition that responds to changing conditions of the cell. Many of the...
- Keyword:
- PML, nuclear organization, no-go decay, mRNA surveillence, Ataxin-1, and stress
- Subject:
- Molecular biology and Cellular biology
- Creator:
- Fanslow, Danielle
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Identifier:
- etdadmin_upload_614059 and http://dissertations.umi.com/northwestern:14390
-
- Description:
- T cells and cancer cells have many common features, including their need to proliferate and their metabolic requirements. In particular, glucose metabolism is highly upregulated in both cancer cells and T cells to support proliferation and other cellular functions. The first step of glycolysis is catalyzed by Hexokinase, which exists...
- Keyword:
- Hexokinase 2 and T Cell
- Subject:
- Immunology and Cellular biology
- Creator:
- Mehta, Manan M
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Identifier:
- etdadmin_upload_616623 and http://dissertations.umi.com/northwestern:14398
-
- Description:
- NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL). Cells harboring this mutation can become the predominant clone in relapsing disease. We studied the effects of this mutant enzyme...
- Keyword:
- cancer genetics, epigenetics, histone post-translational modifications, acute lymphocytic leukemia, and oncology
- Subject:
- Molecular biology, Cellular biology, and Oncology
- Creator:
- Swaroop, Alok
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Identifier:
- etdadmin_upload_626665 and http://dissertations.umi.com/northwestern:14456
-
- Description:
- Inter-organelle contacts facilitate communication between organelles and impact fundamental cellular functions. Investigations into the molecular mechanisms of inter-organelle tethering are still in the early stages, and we are just beginning to appreciate the number and variety of inter-organelle tethers that exist. We have used budding yeast as a model polarized...
- Keyword:
- membrane contact sites and mitochondria
- Subject:
- Biology and Cellular biology
- Creator:
- Kraft, Lauren Michele
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Identifier:
- http://dissertations.umi.com/northwestern:14460 and etdadmin_upload_626904
-
- Description:
- Type I interferon (IFN) is the primary antiviral cytokine establishing a broad and potent antiviral response to protect mammalian cells from virus infection. The functional repertoire of IFN extends to innate and adaptive immunity, neoplastic transformation, resistance and cancer immunotherapy. IFN functions are primarily mediated through the Janus kinase (JAK)...
- Keyword:
- Antiviral, Chromatin, ISG, ISGF3, H2A.Z, and Interferon
- Subject:
- Molecular biology, Virology, and Cellular biology
- Creator:
- Au Yeung, Weng Si (Nancy)
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Identifier:
- http://dissertations.umi.com/northwestern:14409 and etdadmin_upload_618020
-
- Description:
- The cellular innate immune response to viruses is a defense mechanism executed by most cells in the human body to form the initial barrier to virus replication. Detection of viral nucleic acids initiates widespread gene expression changes that combine to establish an antiviral state and stimulate professional immune cell activation....
- Subject:
- Molecular biology and Cellular biology
- Creator:
- Kasat, Roli Mandhana
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Identifier:
- http://dissertations.umi.com/northwestern:14410 and etdadmin_upload_618029
-
- Description:
- Glioblastoma (GBM) is a highly malignant brain tumor that accounts for the most commonly diagnosed type of primary brain tumors in adults. It has a poor prognosis of only 15 months from the time of diagnosis. The gold standard therapy regimen consists of radiotherapy and the chemotherapeutic temozolomide. Both of...
- Keyword:
- one-carbon metabolism, Isocitrate Dehydrogenase, metabolism, cancer, Glioblastoma, and cytosolic serine hydroxymethyltransferase
- Subject:
- Cellular biology
- Creator:
- May, Jasmine Louise
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Identifier:
- etdadmin_upload_593360 and http://dissertations.umi.com/northwestern:14231
-
- Description:
- Endothelial cells (ECs) require glycolysis for proliferation and migration during angiogenesis; however, the necessity for the mitochondrial respiratory chain during angiogenesis is not known. In this study, we report that inhibition of respiratory chain complex III impairs proliferation, but not migration of ECs in vitro by decreasing the NAD+/NADH ratio....
- Keyword:
- Mitochondria and Angiogenesis
- Subject:
- Cellular biology
- Creator:
- Diebold, Lauren P
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Identifier:
- http://dissertations.umi.com/northwestern:14421 and etdadmin_upload_622203
-
- Description:
- Prostate cancer (PCa) is the most common non-cutaneous cancer among U.S. men. Lack of effective treatments for advanced disease make it a significant public health concern. However, PCa’s long natural history makes it an excellent target for prevention approaches that reduce overtreatment of indolent disease, treatment related morbidity, and mortality....
- Keyword:
- Reactive Oxygen Species, Extracellular matrix, Prostate cancer, Organoids, Fatty Acid Oxidation, and SELECT
- Subject:
- Biology, Molecular biology, and Cellular biology
- Creator:
- Njoroge, Rose Nyawira
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Identifier:
- etdadmin_upload_623433 and http://dissertations.umi.com/northwestern:14428
-
- Description:
- Currently, platelet transfusions, possessing profound clinical importance in the clotting of blood and healing of wounds, are entirely derived from human volunteer donors. This approach is limited by a 5-day shelf life, the potential risk of contamination, and differences in donor/recipient immunology. In vivo, platelets are formed when bone marrow...
- Keyword:
- Computational fluid dynamics, Applied sciences, Biological sciences, Megakaryocyte, Cell therapies, and Microfluidic bioreactor
- Subject:
- Chemical engineering, Cellular biology, and Bioengineering
- Creator:
- Martinez, Andres Felipe
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Identifier:
- http://dissertations.umi.com/northwestern:14571 and etdadmin_upload_657405