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Filtering by: Date created tesim 1/1/2018 Subject Driskill Graduate Training Program in Life Sciences

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The MHC Ib Molecule Qa-1 Plays Multiple Roles in the Immune Response to Mycobacterium tuberculosis Infection

Description:

A number of nonclassical MHC Ib molecules recognizing distinct microbial antigens have been implicated in the immune response to Mycobacterium tuberculosis (Mtb). Due to the low polymorphism of MHC Ib molecules within the human population, these molecules and Mtb antigens are attractive targets for better vaccine development. Among these, HLA-E...

Keyword:

T cells and Mycobacterium tuberculosis

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Yao Bian

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/30/2018

Date Modified:

04/30/2018

Date Created:

2017-01-01

Resource Type:

Dissertation
Cancer-Associated Isocitrate Dehydrogenase 1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Description:

Metabolic abnormalities of cancers provide opportunities for novel tumor-specific therapies. Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate (αKG) and the reduction of NAD(P)+ to NAD(P)H. Oncogenic mutations in two IDH-encoding genes (IDH1 and IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and secondary glioblastoma...

Keyword:

lipids, Glioblastoma (GBM), targeted therapy, wild-type IDH1, NADPH, and metabolism

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Andrea Calvert

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/27/2018

Date Modified:

04/27/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

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The MHC Ib Molecule Qa-1 Plays Multiple Roles in the Immune Response to Mycobacterium tuberculosis Infection

Cancer-Associated Isocitrate Dehydrogenase 1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

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