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-
- Description:
- T cells and cancer cells have many common features, including their need to proliferate and their metabolic requirements. In particular, glucose metabolism is highly upregulated in both cancer cells and T cells to support proliferation and other cellular functions. The first step of glycolysis is catalyzed by Hexokinase, which exists...
- Keyword:
- Hexokinase 2 and T Cell
- Subject:
- Cellular biology and Immunology
- Creator:
- Mehta, Manan M
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_616623 and http://dissertations.umi.com/northwestern:14398
-
- Description:
- Interleukin 33 (IL-33) is a complex inflammatory cytokine with diverse functions. In the context of cancer development, depending on the model, the implementation and dosage, and the immune cells involved, IL-33 can elicit dramatically different outcomes. Recent studies, including our own, have explored definitive contributions of the adaptive immunity in...
- Keyword:
- cancer immunology, natural killer cells, interleukin 33, Innate lymphoid cells, immunotherapy, and cd73
- Subject:
- Oncology and Immunology
- Creator:
- Long, Alan Wyndham
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_639294 and http://dissertations.umi.com/northwestern:14519
-
- Description:
- When properly regulated, inflammation leads to the recruitment and activation of circulating leukocytes to maintain and restore tissue homeostasis. Although this process is critical for successful wound healing and the elimination of pathogens and infections, misdirected inflammation can exacerbate pathology and cause substantial morbidity and mortality. Inflammation a fundamental process...
- Keyword:
- Calmodulin Kinase II, Transendothelial Migration, Leukocyte-Endothelial Cell Interactions, IQGAP1, Calcium, and Calmodulin
- Subject:
- Pathology, Molecular biology, and Immunology
- Creator:
- Dalal, Prarthana
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_767426 and http://dissertations.umi.com/northwestern:15311
-
- Description:
- Cancer remains a leading cause of death worldwide, necessitating continued study to explore and unravel its complex etiology. For example, there has been a shift of focus in cancer treatment from surgery and radiotherapy to targeted chemo- and immunotherapies as we gain more knowledge on the hallmarks of cancer (e.g.,...
- Keyword:
- tumor microenvironment, nanomedicine, Checkpoint inhibitor, spherical nucleic acids, gene expression/knockdown, and immunotherapy
- Subject:
- Nanotechnology, Oncology, and Immunology
- Creator:
- Chou, Liyushang
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_884998 and http://dissertations.umi.com/northwestern:15965
-
- Description:
- Staphylococcus aureus (SA) is a leading cause of healthcare-associated and community-acquired infection in the United States. Despite the canonical thinking that antibodies and B cells are the main drivers of protection against extracellular pathogens, T cells are now recognized as critical players in protection against SA in multiple routes of...
- Subject:
- Microbiology and Immunology
- Creator:
- Genardi, Samantha Marie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_784435 and http://dissertations.umi.com/northwestern:15429
-
- Description:
- Stimulation of the cGAS-STING (cycle GMP-AMP synthase-Stimulator of Interferon Genes) pathway increases T cell activation and tracking into the tumor and reverses the immunosuppressive phenotype of myeloid cells. Direct targeting of the STING receptor using synthetic cyclic dinucleotide (CDN) ligands represents an attractive immunotherapeutic strategy for the treatment of lymphocyte-depleted...
- Keyword:
- GBM, Spherical nucleic acids, cGAS, Immunotherapy, and STING
- Subject:
- Biology, Biochemistry, and Immunology
- Creator:
- Mahajan, Akanksha Sanjay
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_983546 and http://dissertations.umi.com/northwestern:16516
-
- Description:
- Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus in these anatomical compartments and how and when the virus reaches those sites. To...
- Subject:
- Virology, Cellular biology, and Immunology
- Creator:
- Madden, Patrick
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15987 and etdadmin_upload_892041
-
- Description:
- Herpes simplex encephalitis (HSE) is a rare and severely debilitating life-threatening disease caused by herpes simplex virus type 1 (HSV-1) infection of the human central nervous system (CNS). The severe and often fatal outcomes of HSE contrast starkly with the more frequent and largely benign consequences of herpes labialis. Whole...
- Keyword:
- Herpes, PNS, Toll like receptors, TLR3, CNS, and Innate immunity
- Subject:
- Virology, Microbiology, and Immunology
- Creator:
- Ewaleifoh, Osefame
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14704 and etdadmin_upload_667366
-
- Description:
- Herpes simplex virus (HSV) encephalitis (HSE) is the most common cause of sporadic fatal encephalitis, and despite targeted antiviral therapy, outcomes remain poor. While rare in adults, neonates are significantly more susceptible to severe HSV disease. Understanding both the host and viral factors that contribute to pathogenesis is critical to...
- Keyword:
- Inflammasome, Neonate, Encephalitis, and Herpes
- Subject:
- Virology, Immunology, and Neurosciences
- Creator:
- Hayes, Cooper Kincaid
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_903123 and http://dissertations.umi.com/northwestern:16088
-
- Description:
- Tissue-infiltrating neutrophils (polymorphonuclear neutrophils [PMNs]) are a prominent feature of inflammatory bowel disease (IBD) and colorectal cancer (CRC), where these immune cells can promote cytotoxicity or exacerbate disease outcomes. We recently showed that in acute colon injury, PMNs can increase DNA double-strand break (DSB) burden and promote genomic instability via...
- Keyword:
- Neutrophils, DNA repair defects, Neutrophil heterogeneity, Tumor angiogenesis, Colorectal cancer, and Genomic instability
- Subject:
- Pathology, Oncology, and Immunology
- Creator:
- Bui, Triet M
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_872984 and http://dissertations.umi.com/northwestern:15896
-
- Description:
- The airway epithelial cells (AECs) lining the conducting passageways of the lung secrete a variety of immunomodulatory factors. One interesting pair of molecules produces by AECs is IL-6 and prostaglandin E2 (PGE2). PGE2 limits lung inflammation and promotes bronchodilation. By contrast, IL-6 drives intense airway inflammation, remodeling, and fibrosis. The...
- Keyword:
- Airway Epithelial Cells, Purinergic Signaling, Interferon, and CRAC channels
- Subject:
- Pharmacology and Immunology
- Creator:
- Kountz, Timothy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15956 and etdadmin_upload_883223
-
- Description:
- Inflammasomes are signaling complexes that link the recognition of pathogen and danger associated molecular patterns (PAMPs and DAMPs) by cytosolic pattern-recognition receptors (PPRs) to the activation of Caspase-1, leading to the release of the pro-inflammatory cytokines interleukin (IL)-1 and IL-18, and the induction of pyroptosis. In addition to the canonical...
- Keyword:
- Caspase-11, oxPAPC, Sepsis, and Non-canonical inflammasome
- Subject:
- Immunology
- Creator:
- Chu, Lan Hoang
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_638156 and http://dissertations.umi.com/northwestern:14507
-
- Description:
- In the United States, allergic disease affects approximately 60 million people and impacts more people every year. While prevalence of allergic disease has steadily increased, there has concurrently been an increase in rates of metabolic syndrome—characterized by increased abdominal girth, decreased sensitivity to insulin, and higher levels of circulating blood...
- Keyword:
- lung, hyperglycemia, immunometabolism, homeostasis, allergy, and metabolism
- Subject:
- Biology, Immunology, and Medicine
- Creator:
- Queener, Ashley
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15602 and etdadmin_upload_824073
-
- Description:
- Herpes simplex virus (HSV) is a ubiquitous human pathogen capable of causing debilitating diseases such as herpes stromal keratitis (HSK) and herpes simplex encephalitis (HSE). Although HSV infection initiates disease pathogenesis, the resulting clinical manifestations are attributed to immunopathological events that occur following viral clearance. To elucidate the molecular mechanisms...
- Keyword:
- herpes stromal keratitis, herpes simplex encephalitis, herpes simplex virus, herpesvirus entry mediator, and TAM receptors
- Subject:
- Virology and Immunology
- Creator:
- Park, Seo Jin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_844174 and http://dissertations.umi.com/northwestern:15730
-
- Description:
- Natural Killer (NK) cell dysfunction is associated with poorer clinical outcome in cancer patients. What regulates NK cell dysfunction in tumor microenvironment is not well understood. NKG2D/NKG2DL pathway is very well recognized as an effective immune axis in tumor immunosurveillance. Abundant evidence from experimental preclinical animal models as well as...
- Subject:
- Biology, Cellular biology, and Immunology
- Creator:
- Dhar, Payal
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15682 and etdadmin_upload_839121
-
- Description:
- CD99-Like 2 (CD99L2) is a 52 kDa type I glycoprotein expressed on leukocytes and endothelial cells as well as other cell types in mice. It is related to CD99, although it shows only 32% sequence identity. CD99L2 has been shown to play a role in leukocyte extravasation in mice under...
- Keyword:
- Inflammation, Transmigration, Leukocyte, PECAM, Endothelial Cell, and CD99-like 2
- Subject:
- Pathology, Molecular biology, and Immunology
- Creator:
- Rutledge, Nakisha S
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_903372 and http://dissertations.umi.com/northwestern:16098
-
- Description:
- Cytokines made by macrophages play a critical role in determining the course of Legionella pneumophila infection. Prior, murine-based modeling indicated that the cytokine response initiated upon recognition of L. pneumophila involves a subset of Toll-like receptors, namely TLR2, TLR5, and TLR9. Using shRNA/siRNA knockdowns and subsequently CRISPR/Cas9 knockouts (KO), I...
- Keyword:
- TLR4, Legionella pneumophila, Macrophage , Toll-like Receptors, and TLR3
- Subject:
- Microbiology, Molecular biology, and Immunology
- Creator:
- Grigoryeva, Lubov Sergeevna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_839521 and http://dissertations.umi.com/northwestern:15684
-
- Description:
- While microbial competition during infection has most often been examined at the genus or species level [1, 2], the dissertation work described herein asked whether interstrain competition plays an important role in determining which bacterial lineages emerge to cause disease. The goal of this dissertation was to examine the strain...
- Keyword:
- Klebsiella pneumoniae, Pneumonia, Strain Identification, StrainSeq, and Acinetobacter baumannii
- Subject:
- Microbiology and Immunology
- Creator:
- Agard, Mallory
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14551 and etdadmin_upload_647535
-
- Description:
- During influenza A virus (IAV) infection, severe lung injury and death result from an exuberant host inflammatory response, or “cytokine storm”, orchestrated by pulmonary epithelial cells. The linear ubiquitin assembly complex (LUBAC), composed of SHARPIN, HOIL-1L and HOIP, is a critical regulator of NF-κB-dependent inflammation. To determine the impact of...
- Subject:
- Immunology
- Creator:
- Brazee, Patricia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14980 and etdadmin_upload_716742
-
- Description:
- Macrophages are one of the most versatile immune cells in the immune system. They are found in nearly every tissue and organ throughout the body. Macrophages play important roles of orchestrating initiation and resolution of inflammation, such as sentineling against pathogens or engulfing apoptotic cells. Macrophages are able to respond...
- Keyword:
- macrophage, cardiovascular diseases, inflammation, and metabolism
- Subject:
- Immunology
- Creator:
- Zhang, Shuang
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_623187 and http://dissertations.umi.com/northwestern:14427