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-
- Description:
- Mycobacterium tuberculosis (Mtb) infection elicits both protein and lipid antigen-specific T cell responses. However, the incorporation of lipid antigens into subunit vaccine strategies and formulations has been under-explored, and the properties of vaccine-induced Mtb lipid-specific memory T cells have remained elusive. Mycolic acid (MA), a major lipid component of the...
- Keyword:
- T cell, nanoparticle, CD1, vaccine, and tuberculosis
- Subject:
- Microbiology and Immunology
- Creator:
- Morgun, Eva
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1015444 and http://dissertations.umi.com/northwestern:16794
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- Description:
- Stimulation of the cGAS-STING (cycle GMP-AMP synthase-Stimulator of Interferon Genes) pathway increases T cell activation and tracking into the tumor and reverses the immunosuppressive phenotype of myeloid cells. Direct targeting of the STING receptor using synthetic cyclic dinucleotide (CDN) ligands represents an attractive immunotherapeutic strategy for the treatment of lymphocyte-depleted...
- Keyword:
- GBM, Spherical nucleic acids, cGAS, Immunotherapy, and STING
- Subject:
- Biology, Biochemistry, and Immunology
- Creator:
- Mahajan, Akanksha Sanjay
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_983546 and http://dissertations.umi.com/northwestern:16516
-
- Description:
- Cancer remains a leading cause of death worldwide, necessitating continued study to explore and unravel its complex etiology. For example, there has been a shift of focus in cancer treatment from surgery and radiotherapy to targeted chemo- and immunotherapies as we gain more knowledge on the hallmarks of cancer (e.g.,...
- Keyword:
- tumor microenvironment, nanomedicine, Checkpoint inhibitor, spherical nucleic acids, gene expression/knockdown, and immunotherapy
- Subject:
- Nanotechnology, Oncology, and Immunology
- Creator:
- Chou, Liyushang
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_884998 and http://dissertations.umi.com/northwestern:15965
-
- Description:
- Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus in these anatomical compartments and how and when the virus reaches those sites. To...
- Subject:
- Virology, Cellular biology, and Immunology
- Creator:
- Madden, Patrick
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15987 and etdadmin_upload_892041
-
- Description:
- Herpes simplex virus (HSV) encephalitis (HSE) is the most common cause of sporadic fatal encephalitis, and despite targeted antiviral therapy, outcomes remain poor. While rare in adults, neonates are significantly more susceptible to severe HSV disease. Understanding both the host and viral factors that contribute to pathogenesis is critical to...
- Keyword:
- Inflammasome, Neonate, Encephalitis, and Herpes
- Subject:
- Virology, Immunology, and Neurosciences
- Creator:
- Hayes, Cooper Kincaid
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_903123 and http://dissertations.umi.com/northwestern:16088
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- Description:
- Tissue-infiltrating neutrophils (polymorphonuclear neutrophils [PMNs]) are a prominent feature of inflammatory bowel disease (IBD) and colorectal cancer (CRC), where these immune cells can promote cytotoxicity or exacerbate disease outcomes. We recently showed that in acute colon injury, PMNs can increase DNA double-strand break (DSB) burden and promote genomic instability via...
- Keyword:
- Neutrophils, DNA repair defects, Neutrophil heterogeneity, Tumor angiogenesis, Colorectal cancer, and Genomic instability
- Subject:
- Pathology, Oncology, and Immunology
- Creator:
- Bui, Triet M
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_872984 and http://dissertations.umi.com/northwestern:15896
-
- Description:
- The airway epithelial cells (AECs) lining the conducting passageways of the lung secrete a variety of immunomodulatory factors. One interesting pair of molecules produces by AECs is IL-6 and prostaglandin E2 (PGE2). PGE2 limits lung inflammation and promotes bronchodilation. By contrast, IL-6 drives intense airway inflammation, remodeling, and fibrosis. The...
- Keyword:
- Airway Epithelial Cells, Purinergic Signaling, Interferon, and CRAC channels
- Subject:
- Pharmacology and Immunology
- Creator:
- Kountz, Timothy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15956 and etdadmin_upload_883223
-
- Description:
- In the United States, allergic disease affects approximately 60 million people and impacts more people every year. While prevalence of allergic disease has steadily increased, there has concurrently been an increase in rates of metabolic syndrome—characterized by increased abdominal girth, decreased sensitivity to insulin, and higher levels of circulating blood...
- Keyword:
- lung, hyperglycemia, immunometabolism, homeostasis, allergy, and metabolism
- Subject:
- Biology, Immunology, and Medicine
- Creator:
- Queener, Ashley
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15602 and etdadmin_upload_824073
-
- Description:
- CD99-Like 2 (CD99L2) is a 52 kDa type I glycoprotein expressed on leukocytes and endothelial cells as well as other cell types in mice. It is related to CD99, although it shows only 32% sequence identity. CD99L2 has been shown to play a role in leukocyte extravasation in mice under...
- Keyword:
- Inflammation, Transmigration, Leukocyte, PECAM, Endothelial Cell, and CD99-like 2
- Subject:
- Pathology, Molecular biology, and Immunology
- Creator:
- Rutledge, Nakisha S
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_903372 and http://dissertations.umi.com/northwestern:16098
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- Description:
- Vaccines, such as those against smallpox virus, polio virus, and yellow fever virus, have saved millions of lives. However, many infectious diseases, such as HIV-1, still lack a preventive vaccine. In addition, various vaccines, such as those against Influenza and SARS-CoV-2 require boosters and may not confer 100% lifelong protection...
- Keyword:
- Vaccines, Interferon, Virus, IFN-I, and Immunity
- Subject:
- Immunology
- Creator:
- Palacio Betancur, Nicole Maria
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_861407 and http://dissertations.umi.com/northwestern:15849
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- Description:
- Regulatory T (Treg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumor immunity. Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of proinflammatory properties, can promote autoimmunity and/or facilitate more effective tumor immunity. A comprehensive understanding...
- Keyword:
- Tumor, Treg, Ubiquitin, Foxp3, Usp21, and Usp22
- Subject:
- Biology, Cellular biology, and Immunology
- Creator:
- Montauti, Elena
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_846345 and http://dissertations.umi.com/northwestern:15780
-
- Description:
- Herpes simplex virus (HSV) is a ubiquitous human pathogen capable of causing debilitating diseases such as herpes stromal keratitis (HSK) and herpes simplex encephalitis (HSE). Although HSV infection initiates disease pathogenesis, the resulting clinical manifestations are attributed to immunopathological events that occur following viral clearance. To elucidate the molecular mechanisms...
- Keyword:
- herpes stromal keratitis, herpes simplex encephalitis, herpes simplex virus, herpesvirus entry mediator, and TAM receptors
- Subject:
- Virology and Immunology
- Creator:
- Park, Seo Jin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_844174 and http://dissertations.umi.com/northwestern:15730
-
- Description:
- Natural Killer (NK) cell dysfunction is associated with poorer clinical outcome in cancer patients. What regulates NK cell dysfunction in tumor microenvironment is not well understood. NKG2D/NKG2DL pathway is very well recognized as an effective immune axis in tumor immunosurveillance. Abundant evidence from experimental preclinical animal models as well as...
- Subject:
- Biology, Cellular biology, and Immunology
- Creator:
- Dhar, Payal
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15682 and etdadmin_upload_839121
-
- Description:
- Cytokines made by macrophages play a critical role in determining the course of Legionella pneumophila infection. Prior, murine-based modeling indicated that the cytokine response initiated upon recognition of L. pneumophila involves a subset of Toll-like receptors, namely TLR2, TLR5, and TLR9. Using shRNA/siRNA knockdowns and subsequently CRISPR/Cas9 knockouts (KO), I...
- Keyword:
- TLR4, Legionella pneumophila, Macrophage , Toll-like Receptors, and TLR3
- Subject:
- Microbiology, Molecular biology, and Immunology
- Creator:
- Grigoryeva, Lubov Sergeevna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_839521 and http://dissertations.umi.com/northwestern:15684
-
- Description:
- Newborns are particularly susceptible to severe forms of herpes simplex virus type I (HSV-1) infection including encephalitis and multisystemic disseminated disease. The underlying age-dependent differences in the immune response that explain this increased susceptibility relative to the adult population remain largely understudied. Evidence from animal studies and genetic studies in...
- Keyword:
- Interferon Response, HSV, Neonatal Immunity, and Encephalitis
- Subject:
- Virology and Immunology
- Creator:
- Giraldo Perez, Daniel
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15674 and etdadmin_upload_838287
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- Description:
- Transplantation is necessary and often the only viable treatment for many forms of end stage organ failure. While advances in immunosuppressive therapies have facilitated largely blocking acute rejection, 5-10 year post-transplant attrition rates have not significantly improved in the past 30 years. The predominant antigen facilitating the alloimmune response is...
- Subject:
- Biomedical engineering and Immunology
- Creator:
- Shah, Sahil Vijendra
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/06/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15715 and etdadmin_upload_843477
-
- Description:
- Staphylococcus aureus (SA) is a leading cause of healthcare-associated and community-acquired infection in the United States. Despite the canonical thinking that antibodies and B cells are the main drivers of protection against extracellular pathogens, T cells are now recognized as critical players in protection against SA in multiple routes of...
- Subject:
- Microbiology and Immunology
- Creator:
- Genardi, Samantha Marie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_784435 and http://dissertations.umi.com/northwestern:15429
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- Description:
- When properly regulated, inflammation leads to the recruitment and activation of circulating leukocytes to maintain and restore tissue homeostasis. Although this process is critical for successful wound healing and the elimination of pathogens and infections, misdirected inflammation can exacerbate pathology and cause substantial morbidity and mortality. Inflammation a fundamental process...
- Keyword:
- Calmodulin Kinase II, Transendothelial Migration, Leukocyte-Endothelial Cell Interactions, IQGAP1, Calcium, and Calmodulin
- Subject:
- Pathology, Molecular biology, and Immunology
- Creator:
- Dalal, Prarthana
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_767426 and http://dissertations.umi.com/northwestern:15311
-
- Description:
- This dissertation focuses on the development of quantitative approaches for characterizing endogenous signaling pathways and designing new pathways in mammalian cells. I demonstrate how mathematical descriptions that are formulated to explain gene expression patterns can also serve as a powerful springboard for deeper analyses into the properties and functions of...
- Keyword:
- macrophage, systems biology, receptor, computational biology, transcription factor, and synthetic biology
- Subject:
- Bioengineering, Molecular biology, and Immunology
- Creator:
- Muldoon, Joseph Jacob
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15256 and etdadmin_upload_764084
-
- Description:
- Bacteria often coordinate virulence factors to fine-tune the host response during infection. These coordinated events can include toxins counteracting or amplifying effects of another toxin or though regulating the stability of virulence factors to remove their function once it is no longer needed. Multifunctional autoprocessing repeats-in toxin (MARTX) toxins are...
- Keyword:
- Toxin, MAPK, IL-8, Vibrio vulnificus, MARTX, and Vibrio cholera
- Subject:
- Microbiology, Molecular biology, and Immunology
- Creator:
- Woida, Patrick James
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15369 and etdadmin_upload_778406