Index Catalog // Arch : Northwestern University Institutional Repository

Derivation of Cardiomyocytes from Embryonic Stem cells and Development of Techniques to Study Cardiac Lineage

Description:: Embryonic stem cells have the potential to differentiate into ectodermal, mesodermal and endodermal derivatives. This property makes them a valuable source of tissue specific progenitor and differentiated cells that can be used for cell replacement therapy. The first goal of this thesis is to test if cardiogenesis from embryonic stem...
Keyword:: Cell Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Achuta K Guddati
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/08/2018
Date Modified:: 10/08/2018
Date Created:: 2008-05-09
Resource Type:: Dissertation

Luteinizing Hormone Receptor Signaling Regulates MAP2D Phosphorylation in Preovulatory Granulosa Cells

Description:: The actions of luteinizing hormone (LH) to induce ovulation and luteinization of preovulatory follicles are mediated principally by activation of cAMP-dependent protein kinase (PKA) in granulosa cells. PKA activity is targeted to specific cellular locations by A-kinase anchoring proteins (AKAPs). I previously showed that follicle-stimulating hormone (FSH) induces expression of...
Keyword:: cyloskeleton, MAP2, vimentin, ovary, granulosa cell, and luteinizing hormone
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Maxfield Patrick Flynn
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/03/2018
Date Modified:: 10/03/2018
Date Created:: 2008-08-11
Resource Type:: Dissertation

Control of Mitochondrial Function and Cell Cycle Progression by PGC-1-Related Coactivator (PRC)

Description:: PRC is a PGC-1 coactivator family member responsive to serum growth factors and up regulated in proliferating cells. Unlike PGC-1α and PGC-1β, PRC has not been studied extensively and and its function or regulation remains largely unknown. Both PGC-1α and PGC-1β have been shown to be important regulators of mitochondrial...
Keyword:: Biochemistry and Chemical
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Kristel Vercauteren
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/02/2018
Date Modified:: 10/02/2018
Date Created:: 2008-12-08
Resource Type:: Dissertation

Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

Description:: Early Growth Response genes (Egr1-4) are transcriptional mediators of signals governing growth and differentiation. In sympathetic neuron-derived cell lines, Egr1 is induced by NGF signaling, which is required for sympathetic neuron survival, differentiation and target organ innervation. In the absence of identifiable sympathetic defects in Egr1-deficient mice, we investigated the...
Keyword:: NGF, sympathetic nervous system, and Egr3
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Laurie Christine Eldredge
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/01/2018
Date Modified:: 10/01/2018
Date Created:: 2008-12-08
Resource Type:: Dissertation

Structural and Conformational Requirements of Membrane Fusion Mediated by the Parainfluenza Virus 5 Fusion Protein

Description:: Fusion of biological membranes is dictated by the interaction between specialized membrane proteins and the lipid bilayer. Parainfluenza virus 5 (PIV5) mediates fusion using two surface glycoproteins: the fusion protein (F) and the attachment protein hemagglutinin-neuraminidase (HN). Activation of membrane fusion of PIV5 typically occurs at neutral pH, and involves...
Keyword:: Class I virus fusion, PIV5, fusion protein, and Membrane fusion
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Mei Lin Bissonnette
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/01/2018
Date Modified:: 10/01/2018
Date Created:: 2008-11-06
Resource Type:: Dissertation

The Role of TGF-beta Variants in Breast Cancer

Description:: TGF-β has been named the molecular Jekyll and Hyde of cancer due to its ability to both suppress and promote tumor development. Components of the TGF-β signaling pathway are often mutated in cancer to inhibit the tumor suppressor roles of TGF-β. Our lab studies how a 3-alanine deletion in the...
Keyword:: Biology and Genetics
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Diana Susan Rosman
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/01/2018
Date Modified:: 10/01/2018
Date Created:: 2008-10-14
Resource Type:: Dissertation

Plakophilin 2: Critical Roles in Intercellular Junction Assembly and Maturation via Regulation of Protein Kinase C and Actin

Description:: Desmosomes are adhesive complexes found at sites of intercellular contact that are essential for mediating cell-cell adhesion. These junctions undergo regulated assembly and reorganization during processes such as embryogenesis and wound healing. Plakophilins (PKPs) are armadillo family members related to the classic cadherin-associated protein p120ctn. PKPs localize to the cytoplasmic...
Keyword:: desmosome, cytoskeleton, cell-cell adhesion, armadillo, and plakophilin
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Amanda Elisabeth Bass-Zubek
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-09-18
Resource Type:: Dissertation

Energy Deprivation Elevates BACE1 Protein Levels and Promotes Amyloidogenesis via EIF2alpha Phosphorylation

Description:: The cause(s) of Aβ overproduction and accumulation in SAD are unknown; however, several lines of evidence indicate that impaired energy metabolism in the brain may be involved. Furthermore, the rate-limiting enzyme in Aβ production, BACE1, is elevated in SAD brains around amyloid plaques, indicating that BACE1 may also play a...
Keyword:: translation, energy metabolism, BACE1, amyloid, and Alzheimer's disease
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Tracy O'Connor
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-12-04
Resource Type:: Dissertation

Mechanisms of RNA Mediated Silencing in S. pombe

Description:: Mechanisms of RNA Mediated Silencing in S. pombe Christina A. Lawrence Heterochromatin of eukaryotic genomes has classically been defined as condensed chromatin that is repressive to transcription and typically resides at highly repetitive regions of the genome. Genetic and molecular analyses have demonstrated that these regions are essential for genome...
Keyword:: heterochromatin, Yeast, epigenetics, and RNAi
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Christina Lawrence
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-12-05
Resource Type:: Dissertation

Epstein-Barr Virus Glycoprotein 42: The Dynamic Trigger of B-cell Membrane Fusion

Description:: Epstein-Barr virus (EBV) is a human herpesvirus that is able to infect both epithelial cells as well as B lymphocytes, where the virus stablishes life-long latency in the host. Five glycoproteins are involved in infection of B cells: gp350/220 for initial tethering of the virus to the cell via CD21,...
Keyword:: membrane fusion, inhibitory peptide, viral entry, Epstein-Barr virus, gp42, and herpesviruses
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Amanda Renee Kim Eun-Ja Silva Lowrey
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-12-01
Resource Type:: Dissertation

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Derivation of Cardiomyocytes from Embryonic Stem cells and Development of Techniques to Study Cardiac Lineage

Luteinizing Hormone Receptor Signaling Regulates MAP2D Phosphorylation in Preovulatory Granulosa Cells

Control of Mitochondrial Function and Cell Cycle Progression by PGC-1-Related Coactivator (PRC)

Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

Structural and Conformational Requirements of Membrane Fusion Mediated by the Parainfluenza Virus 5 Fusion Protein

The Role of TGF-beta Variants in Breast Cancer

Plakophilin 2: Critical Roles in Intercellular Junction Assembly and Maturation via Regulation of Protein Kinase C and Actin

Energy Deprivation Elevates BACE1 Protein Levels and Promotes Amyloidogenesis via EIF2alpha Phosphorylation

Mechanisms of RNA Mediated Silencing in S. pombe

Epstein-Barr Virus Glycoprotein 42: The Dynamic Trigger of B-cell Membrane Fusion

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