Index Catalog // Arch : Northwestern University Institutional Repository

Development of Alveolar Epithelial Type II Cell-Specific Nuclear Targeting Vectors for Gene Therapy

Description:: Although non-viral gene therapy has great potential for use in the lung, several problems including inefficient gene transfer and expression and the relative lack of cell-specific targeting have limited its applications. The two approaches that have been used to target genes to desired cell types are through specific ligand-receptor interactions...
Keyword:: nuclear import, SP-C, gene therapy, plasmid, and non-viral
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: James Vincent DeGiulio
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/16/2018
Date Modified:: 08/16/2018
Date Created:: 2007-09-24
Resource Type:: Dissertation

Barbed End Regulation and the Formation of Actin Protrusive Structures

Description:: Barbed end regulation is critical to the formation of the actin-based protrusive structures, lamellipodia and filopodia. In this body of work we have chosen to focus on two main activities, filament termination by the heterodimeric Capping protein (CP) and continued filament elongation by the Ena/VASP family of proteins. We demonstrate...
Keyword:: actin protrusive structures, lamellipodia, filopodia, Ena/VASP, Capping Protein, and actin
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Derek Anthony Applewhite
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/02/2018
Date Modified:: 08/02/2018
Date Created:: 2007-09-04
Resource Type:: Dissertation

Understanding the mechanism of protein processing by the proteasome

Description:: The ubiquitin-proteasome system degrades regulatory proteins and thereby controls a broad range of cellular processes such as the cell cycle, DNA-repair, gene transcription and signal transduction. The proteasome typically degrades its substrates completely into small peptides. However, biological exceptions do occur. For example, the activity of a handful of transcriptional...
Keyword:: Chemistry, Biology, and Cell
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Tian Lin
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/05/2018
Date Modified:: 06/05/2018
Date Created:: 2007-05-09
Resource Type:: Dissertation

Functional Characterization of Epstein-Barr Virus gH/gL Glycoprotein Complex in Fusion

Description:: Epstein-Barr virus (EBV) is a human gamma-herpesvirus that primarily infects B cells and epithelial cells. While the glycoproteins required for entry into these two cell types differ, the gH/gL glycoprotein complex is essential for entry into both epithelial and B cells. Analysis of gH protein sequences from three gamma-herpesviruses: EBV,...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Jasmina Omerovic
Owner:: Scholarly Digital Publishing
Date Uploaded:: 06/05/2018
Date Modified:: 06/05/2018
Date Created:: 2007-05-09
Resource Type:: Dissertation

Pdlim7 regulates nuclear/cytoplasmic localization and activity of Tbx5 during cardiac development

Description:: The T-box transcription factor, Tbx5, is involved in heart development and congenital disease. For example mutations in human TBX5 lead to Holt-Oram syndrome, a disease characterized by a range of heart and arm malformations. Tbx5 gene activity has been perturbed in several animal models including the chicken, mouse, and zebrafish....
Keyword:: Heart, Zebrafish, Pdlim7, and Tbx5
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Troy Camarata
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-11-26
Resource Type:: Dissertation

Analysis of Neutral Lipids and the Genes Underlying Their Biosynthesis in P.Falciparum and S. Typhimurium

Description:: Plants, animals, and yeast have the capacity to produce and accumulate neutral lipids, sterol esters and triacylglycerol (TAG). However, their accumulation and the genes underlying their synthesis in intracellular microorganisms are poorly understood. Plasmodium falciparum is a parasitic protozoan that causes the most virulent form of human malaria. During erythrocytic...
Keyword:: Plasmodium, Neutral Lipids, Cholestrol Esters, Salmonella, Triacylglycerol, and SseJ
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Parwez Nawabi
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/08/2018
Date Modified:: 09/08/2018
Date Created:: 2008-03-26
Resource Type:: Dissertation

Structural and Functional Analyses of Herpes Simplex Virus Type1 Glycoproteins B and L, Two Essential Components of the Viral Fusogenic Complex

Description:: Herpes simplex virus (HSV) infection of host cells requires virus attachment to the cell surface and subsequent membrane fusion between the virus envelope and host cell membrane to deliver the nucleocapsid containing the viral genome into the host cell. A proposed mechanism for HSV glycoprotein-induced membrane fusion is gD binding...
Keyword:: Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Erick Lin
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/17/2018
Date Modified:: 09/17/2018
Date Created:: 2008-07-17
Resource Type:: Dissertation

Derivation of Cardiomyocytes from Embryonic Stem cells and Development of Techniques to Study Cardiac Lineage

Description:: Embryonic stem cells have the potential to differentiate into ectodermal, mesodermal and endodermal derivatives. This property makes them a valuable source of tissue specific progenitor and differentiated cells that can be used for cell replacement therapy. The first goal of this thesis is to test if cardiogenesis from embryonic stem...
Keyword:: Cell Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Achuta K Guddati
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/08/2018
Date Modified:: 10/08/2018
Date Created:: 2008-05-09
Resource Type:: Dissertation

Plakophilin 2: Critical Roles in Intercellular Junction Assembly and Maturation via Regulation of Protein Kinase C and Actin

Description:: Desmosomes are adhesive complexes found at sites of intercellular contact that are essential for mediating cell-cell adhesion. These junctions undergo regulated assembly and reorganization during processes such as embryogenesis and wound healing. Plakophilins (PKPs) are armadillo family members related to the classic cadherin-associated protein p120ctn. PKPs localize to the cytoplasmic...
Keyword:: desmosome, cytoskeleton, cell-cell adhesion, armadillo, and plakophilin
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Amanda Elisabeth Bass-Zubek
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-09-18
Resource Type:: Dissertation

Analysis of Latent Membrane Protein (LMP) 2A Signaling Through Src Family Kinases and the Role of LMP2B in Modulating LMP2A Signaling

Description:: Latent membrane protein 2A (LMP2A) and LMP2B are viral proteins expressed during Epstein-Barr virus (EBV) latency in EBV-infected B cells both in cell culture and in vivo. Although Lyn has been shown to be important in mediating LMP2A signaling, it is still unclear if Lyn is used preferentially or if...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Mark Rovedo
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/18/2018
Date Modified:: 09/18/2018
Date Created:: 2008-09-03
Resource Type:: Dissertation

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Development of Alveolar Epithelial Type II Cell-Specific Nuclear Targeting Vectors for Gene Therapy

Barbed End Regulation and the Formation of Actin Protrusive Structures

Understanding the mechanism of protein processing by the proteasome

Functional Characterization of Epstein-Barr Virus gH/gL Glycoprotein Complex in Fusion

Pdlim7 regulates nuclear/cytoplasmic localization and activity of Tbx5 during cardiac development

Analysis of Neutral Lipids and the Genes Underlying Their Biosynthesis in P.Falciparum and S. Typhimurium

Structural and Functional Analyses of Herpes Simplex Virus Type1 Glycoproteins B and L, Two Essential Components of the Viral Fusogenic Complex

Derivation of Cardiomyocytes from Embryonic Stem cells and Development of Techniques to Study Cardiac Lineage

Plakophilin 2: Critical Roles in Intercellular Junction Assembly and Maturation via Regulation of Protein Kinase C and Actin

Analysis of Latent Membrane Protein (LMP) 2A Signaling Through Src Family Kinases and the Role of LMP2B in Modulating LMP2A Signaling

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