Index Catalog // Arch : Northwestern University Institutional Repository

Microenvironment Regulation of Proteinase Expression and E-cadherin Ectodomain Generation in Ovarian Cancer

Description:: Most women diagnosed with epithelial ovarian carcinoma (EOC) initially present with metastases, but little is known about the regulation of ovarian tumor cell dissemination by the tumor microenvironment. Because ovarian cancer cell dissemination is mostly limited to the peritoneal cavity and often results in the accumulation of malignant ascites, the...
Keyword:: Biology and Cell
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Jaime Symowicz
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/21/2018
Date Modified:: 05/21/2018
Date Created:: 2007-03-12
Resource Type:: Dissertation

The Role Of The mTOR Pathway In Mediating The Biological Effects Of Arsenic Trioxide

Description:: Arsenic trioxide (As203) is an arsenic-derivative that exhibits potent growth inhibitory effects against malignant cells. The remarkable antitumor effects of As203 in vitro and in vivo have prompted the development of various clinical trials that established its activity in acute promyelocytic leukemia (APL). As203 is part of the standard treatment...
Keyword:: Biology, Cell, and Health Sciences
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Patrick Jang Yoon
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/21/2018
Date Modified:: 05/21/2018
Date Created:: 2007-03-12
Resource Type:: Dissertation

Type II Secretion and Secreted Ppiases Promote Low Temperature Growth and Survival in Legionella pneumophila

Description:: PilD is an enzyme that processes prepilins that are part of the type II protein secretion apparatus and the type IV piliation machinery. Using a Legionella pneumophila pilDlacZ fusion strain to measure transcription, we observed a 20% increase in beta-galactosidase levels at 30°C vs. 37°C. At 25°C and 17°C vs....
Keyword:: Microbiology and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Maria Soderberg
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/06/2018
Date Modified:: 09/06/2018
Date Created:: 2008-03-25
Resource Type:: Dissertation

Analysis of Latent Membrane Protein (LMP) 2A Signaling Through Src Family Kinases and the Role of LMP2B in Modulating LMP2A Signaling

Description:: Latent membrane protein 2A (LMP2A) and LMP2B are viral proteins expressed during Epstein-Barr virus (EBV) latency in EBV-infected B cells both in cell culture and in vivo. Although Lyn has been shown to be important in mediating LMP2A signaling, it is still unclear if Lyn is used preferentially or if...
Keyword:: Molecular and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Mark Rovedo
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/18/2018
Date Modified:: 09/18/2018
Date Created:: 2008-09-03
Resource Type:: Dissertation

Analysis of Neutral Lipids and the Genes Underlying Their Biosynthesis in P.Falciparum and S. Typhimurium

Description:: Plants, animals, and yeast have the capacity to produce and accumulate neutral lipids, sterol esters and triacylglycerol (TAG). However, their accumulation and the genes underlying their synthesis in intracellular microorganisms are poorly understood. Plasmodium falciparum is a parasitic protozoan that causes the most virulent form of human malaria. During erythrocytic...
Keyword:: Plasmodium, Neutral Lipids, Cholestrol Esters, Salmonella, Triacylglycerol, and SseJ
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Parwez Nawabi
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/08/2018
Date Modified:: 09/08/2018
Date Created:: 2008-03-26
Resource Type:: Dissertation

Analysis of the Requirement of Notch Signaling for EBV LMP2A Function in vitro and in vivo

Description:: Epstein Barr Virus (EBV) is associated with malignancies of lymphoid and epithelial origin. While the precise role of EBV in oncogenesis remains elusive, latent membrane protein 2A (LMP2A) is detected in all EBV-associated malignancies, implicating LMP2A in their pathogenesis. Interestingly, LMP2A is expressed in EBV-associated malignancies such as Burkitt's Lymphoma,...
Keyword:: Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Leah J Anderson
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/31/2018
Date Modified:: 08/31/2018
Date Created:: 2008-03-31
Resource Type:: Dissertation

Control of Mitochondrial Function and Cell Cycle Progression by PGC-1-Related Coactivator (PRC)

Description:: PRC is a PGC-1 coactivator family member responsive to serum growth factors and up regulated in proliferating cells. Unlike PGC-1α and PGC-1β, PRC has not been studied extensively and and its function or regulation remains largely unknown. Both PGC-1α and PGC-1β have been shown to be important regulators of mitochondrial...
Keyword:: Biochemistry and Chemical
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Kristel Vercauteren
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/02/2018
Date Modified:: 10/02/2018
Date Created:: 2008-12-08
Resource Type:: Dissertation

Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

Description:: Early Growth Response genes (Egr1-4) are transcriptional mediators of signals governing growth and differentiation. In sympathetic neuron-derived cell lines, Egr1 is induced by NGF signaling, which is required for sympathetic neuron survival, differentiation and target organ innervation. In the absence of identifiable sympathetic defects in Egr1-deficient mice, we investigated the...
Keyword:: NGF, sympathetic nervous system, and Egr3
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Laurie Christine Eldredge
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/01/2018
Date Modified:: 10/01/2018
Date Created:: 2008-12-08
Resource Type:: Dissertation

Energy Deprivation Elevates BACE1 Protein Levels and Promotes Amyloidogenesis via EIF2alpha Phosphorylation

Description:: The cause(s) of Aβ overproduction and accumulation in SAD are unknown; however, several lines of evidence indicate that impaired energy metabolism in the brain may be involved. Furthermore, the rate-limiting enzyme in Aβ production, BACE1, is elevated in SAD brains around amyloid plaques, indicating that BACE1 may also play a...
Keyword:: translation, energy metabolism, BACE1, amyloid, and Alzheimer's disease
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Tracy O'Connor
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-12-04
Resource Type:: Dissertation

Mechanisms of RNA Mediated Silencing in S. pombe

Description:: Mechanisms of RNA Mediated Silencing in S. pombe Christina A. Lawrence Heterochromatin of eukaryotic genomes has classically been defined as condensed chromatin that is repressive to transcription and typically resides at highly repetitive regions of the genome. Genetic and molecular analyses have demonstrated that these regions are essential for genome...
Keyword:: heterochromatin, Yeast, epigenetics, and RNAi
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Christina Lawrence
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-12-05
Resource Type:: Dissertation

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Microenvironment Regulation of Proteinase Expression and E-cadherin Ectodomain Generation in Ovarian Cancer

The Role Of The mTOR Pathway In Mediating The Biological Effects Of Arsenic Trioxide

Type II Secretion and Secreted Ppiases Promote Low Temperature Growth and Survival in Legionella pneumophila

Analysis of Latent Membrane Protein (LMP) 2A Signaling Through Src Family Kinases and the Role of LMP2B in Modulating LMP2A Signaling

Analysis of Neutral Lipids and the Genes Underlying Their Biosynthesis in P.Falciparum and S. Typhimurium

Analysis of the Requirement of Notch Signaling for EBV LMP2A Function in vitro and in vivo

Control of Mitochondrial Function and Cell Cycle Progression by PGC-1-Related Coactivator (PRC)

Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

Energy Deprivation Elevates BACE1 Protein Levels and Promotes Amyloidogenesis via EIF2alpha Phosphorylation

Mechanisms of RNA Mediated Silencing in S. pombe

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