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CXCR7 Receptor Signaling in the Nervous System

Description:

Chemokines, such as Stromal Derived Factor 1 (SDF-1 or CXCL12) and their G protein coupled receptors (GPCRs) are well known regulators of the development and functions of numerous tissues. CXCL12 has two receptors: CXCR4 and CXCR7 or atypical chemokine receptor 3 (ACKR3). CXCR7 has been described as an atypical “biased”...

Keyword:

CXCR4 and CXCR7

Subject:

Pharmacology and Neurosciences

Creator:

Hopkins, Brittany E

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15737 and etdadmin_upload_844430
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR-Plasticity

Description:

In mature neurons, postsynaptic NMDARs are segregated into two populations, synaptic and extrasynaptic NMDARs, which differ in localization, function, and associated intracellular cascades. These two pools are connected via lateral diffusion, and receptor exchange between them modulates synaptic NMDAR content (NMDAR-plasticity). Here, we identify the phosphorylation of the PDZ-ligand of...

Keyword:

NMDAR, NMDAR-plasticity, Extrasynaptic NMDAR, GluN2B, and PP1

Subject:

Pharmacology and Neurosciences

Creator:

Chiu, Andrew Michael

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_669024 and http://dissertations.umi.com/northwestern:14717

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CXCR7 Receptor Signaling in the Nervous System

NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR-Plasticity

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