Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Multiple facets of the natural trajectory of glioma remain poorly understood, which results in a universally poor prognosis for patients with glioma. Many patients with glioma experience tumor-associated epilepsy (TAE) throughout their disease course, but the mechanism by which TAE occurs, who is at continued risk for TAE, and whether...
Keyword:: Glioma, Glioblastoma, Infiltration, IDH, and Seizure
Subject:: Oncology and Cellular biology
Creator:: Drumm, Michael Raymond
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16570 and etdadmin_upload_985850

Description:: Fat represents an important source of energy for ovarian cancer (OC) cells and is supplied either through import from the tumor milieu or via de novo lipogenesis. During fast tumor growth, when nutrients are scarce, lipogenesis becomes the primary source of fatty acids. Stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in...
Keyword:: ER stress, Fatty acids, Ovarian cancer, and Lipid metabolism
Subject:: Bioinformatics, Oncology, and Cellular biology
Creator:: Zhao, Guangyuan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_940639 and http://dissertations.umi.com/northwestern:16324

Description:: NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL). Cells harboring this mutation can become the predominant clone in relapsing disease. We studied the effects of this mutant enzyme...
Keyword:: oncology, acute lymphocytic leukemia, histone post-translational modifications, epigenetics, and cancer genetics
Subject:: Molecular biology, Oncology, and Cellular biology
Creator:: Swaroop, Alok
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14456 and etdadmin_upload_626665

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