Amyloid beta oligomers (AβOs) are a key instigator of neurodegeneration in Alzheimer’s disease (AD). The work presented in this thesis includes three disease-modifying approaches to disrupt pathological AβO-related mechanisms in AD: (1) inhibiting AβO buildup, (2) blocking AβO-induced tau phosphorylation, and (3) neutralizing AβOs. These three approaches were tested in...
Since Infrared radiation was discovered in 1800s, the research and applications on the infrared regime have been continually developed. The infrared detectors are the key technology in these applications and have been successfully used for medical imaging, light detection and ranging (LiDAR), free-space optical communication, target tracking and object identification...
A fundamental materials science question is “why and how will this material form?” The experimental,computation, and time resources necessary to answer this question consume significant resources due to the
predominantly trial-and-error based approaches common in materials research. This dissertation reintroduces
a number of fundamental thermodynamics-based tools for the study of...
Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins, desmogleins and desmocollins, are related to the classical cadherins but their cytoplasmic domains are tailored for anchoring intermediate filaments instead of actin to sites of cell-cell adhesion. The...
Many computing technologies are primarily useful because of the existence of some set of data created by people, intentionally in some cases and unintentionally in others. For instance, technologies like search engines, recommender systems, classifiers, and language models are all dependent on digital records of things people have said, done,...
To better prepare for earthquakes, we need to know how large they will be, how strong the shaking will be, and how often they will occur. To answer these questions, seismologists look to past earthquakes to better understand future hazards. Earthquakes, however, are complex physical phenomena that occur on timescales...
DNA is extremely versatile and powerful, both as a construct in biological applications and as a ligand in materials design due to the fact that its recognition properties can be programmed through sequence and length. Spherical nucleic acids (SNAs), nanoparticles surrounded by a dense shell of DNA or RNA, are...
Computational material engineering (CME) has increased the pace of material development many folds in recent years by taking advantage of computational tools such as using simulations as replacement to experiments, and building complicated processing-structure-property relationships using advanced machine learning tools. The importance of CME is underscored by new computation-based design...
We consider constant scalar curvature K ̈ahler metrics on a smooth minimal model of general type in a neighborhood of the canonical class, which is the perturbation of the canonical class by a fixed K ̈ahler metric. We show that sequences of such metrics converge smoothly on compact subsets away...
Gerotranscendence involves feelings of coherence with one’s sense of self, greater acceptance of one’s own life, and connectedness to others across time and space. Gerotranscendence is thought to increase with age. The present study is the first longitudinal effort to investigate changes in gerotranscendence across late midlife using life story...