Newborns are particularly susceptible to severe forms of herpes simplex virus type I (HSV-1) infection including encephalitis and multisystemic disseminated disease. The underlying age-dependent differences in the immune response that explain this increased susceptibility relative to the adult population remain largely understudied. Evidence from animal studies and genetic studies in...
This dissertation consists of three papers on methods for meta-analysis with few studies. These papers are concerned with proper inference from meta-analysis models that combine data from a small number of studies using fixed and random-effects models. Chapter 1 provides an introduction to meta-analysis, the motivation for this work and...
“‘The Indians Say’: Settler Colonialism and the Scientific Study of North America, 1722 to 1848” examines the issue of evidence and credibility within natural history by following the circulation of Indigenous testimony through Anglophone networks of scientific knowledge production. By merging the history of science with Native American and Indigenous...
This thesis proposes a robust multi-pronged approach to study the effect of nanoparticles on cells. In the first place, this work is focused on investigation of the protein corona that accumulates on the surface of nanoparticles internalized by the cells and their poly-pathway effects on protein availability and messenger RNA...
Manufacturing processes are known for their intricacies in changing material shapes and properties. New generations of manufacturing technologies, known as flexible manufacturing, are moving toward design freedom, which allows producing parts with optimized geometries and high customizations at an affordable cost even for low-volume productions. Two prominent flexible manufacturing processes...
Chemokines, such as Stromal Derived Factor 1 (SDF-1 or CXCL12) and their G protein coupled receptors (GPCRs) are well known regulators of the development and functions of numerous tissues. CXCL12 has two receptors: CXCR4 and CXCR7 or atypical chemokine receptor 3 (ACKR3). CXCR7 has been described as an atypical “biased”...
The purpose of this research project was to highlight that there are different perspectives on mental health that stem from various experiences. All of these views should be valued and not discriminated against for any reason other than that they are different. As a child of Soviet Immigrants, I quickly...
The explosion of data in the digital age has provided new possibilities for policy creation,the development of knowledge, and societal innovations. In this way, data becomes an essential
tool in personal decision-making, legal change, and policy creation as we leverage new forms of
data to understand social phenomena. But along...
Cyber-physical systems (CPS), as a multidisciplinary area, have been widely adopted in our daily life and attract experts from various fields. CPS aims to achieve real-time and resilient connection with physical world through integration of computation, communication and control technologies. Many CPS systems, such as automotive, avionics, and industrial system,...
High-throughput methods enable rapid experimentation and/or screening of thousands of samples simultaneously. Mass-spectrometry based methods are of particular interest since they provide a label-free way to detect all species present in a given reaction mixture. To circumvent sample preparation and purification—which is typically a slow process—the Mrksich group developed a...