Rsp5 is a ubiquitin ligase that controls a broad range of cellular processes in budding yeast and is part of a large family of proteins that controls analogous processes in mammalian cells. Although Rsp5 targets a number of different substrates for ubiquitination, the mechanisms that regulate Rsp5 catalytic activity are...
The utilization of hydrofluoric acid for the preparation of silver vanadium oxide fluorides has been advanced for the synthesis of Ag<sub>4</sub>V<sub>2</sub>O<sub>6</sub>F<sub>2</sub> and Ag<sub>3</sub>VO<sub>2</sub>F<sub>4</sub>. Silver-rich metal oxide fluorides are important battery cathode materials due to the high reduction potential of silver vs. Li, which is made even higher by the incorporation...
This dissertation explores the reciprocal relationship between international politics and digital computation since the 1960s by examining the first attempts to use computer simulation to credibly forecast our planet’s economic and environmental future on a global scale. In particular, this project offers the first sustained historical analysis of the origins...
Achievement gaps between students from different SES and racial/ethnic backgrounds stubbornly persist despite decades of policy interventions. My dissertation focuses on several unexpected sources of stress and disruption that may be related to the achievement gap: sunlight exposure, a sister’s teen childbearing, and nearby violent crime. I demonstrate that these...
This paper examines the relationship between a party'’'s descriptive representation of women and its ideological proximity to female and male voters. I find that male and female voters are both objectively closer to parties with more females in their delegations. However, males are more likely to subjectively assess parties with...
To analyze institutional dynamics, it is first necessary to determine when change has occurred, when not, and the nature and magnitude of change. If social institutions are defined in terms of rules, then a change of rules forms the core of institutional change. A number of complications arise from the...
What are the origins of race-based affirmative action in college admissions? With only a few exceptions, there remain few evidence-based accounts of when and why such programs emerged among selective institutions of higher education; how heavily they weighed racial considerations; and how exactly race was taken into account. This paper...
In order to understand the role of international courts (ICs) in the international legal system, this chapter examines 25 permanent international courts by analyzing four roles that states have delegated to courts: enforcement, administrative review, constitutional review, and dispute settlement. The chapter finds that ICs can become not only agents...
This paper explores the link between the public policy and the survival strategies of a hybrid political regime. Using the case of higher education in Russia, I show how the Russian state elites use the policy tools widespread in Western democracies to achieve domestic political goals. Introduction of quasi-market mechanisms...