The ubiquitin-proteasome system degrades regulatory proteins and thereby controls a broad range of cellular processes such as the cell cycle, DNA-repair, gene transcription and signal transduction. The proteasome typically degrades its substrates completely into small peptides. However, biological exceptions do occur. For example, the activity of a handful of transcriptional...
The [(salen)CrCl + LB] catalyst system was found to be a highly active catalyst system for the [aziridine + CO<sub>2</sub>] coupling reaction, and exhibited a marked preference for the formation of 5-substituted oxazolidinone product, especially in the absence of cocatalyst. The activity of this catalyst system is optimized by modifying...
This dissertation examines the impact of product returns on effective supply chain management. Within this area of research, known as Closed-Loop Supply Chain Management, we consider both strategic and tactical level reverse logistics and inventory management problems from the perspective of a firm which must efficiently process returned items. More...
The stratigraphic record of the Phanerozoic provides key evidence of temporal changes in the global carbon cycle over the past 560 myr of Earth history. Measurements of carbon concentrations in ancient marine sediment, in conjunction with a chronological framework, provide a means to reconstruct burial flux history and, thus, evaluate...
The representation and communication of spatial information is important to the functioning of children and adults in the physical world. Yet little research has included both areas in the same studies. This research program was designed to investigate both the communication and representation of spatial information within a developmental context....
This dissertation expands on the existing disclosure theory by considering the monitoring role of a firm's disclosure as well as recognizing how a firm's disclosure is influenced by the firm's monitoring mechanisms. The first chapter of the dissertation examines the effect of corporate governance on a firm's earnings reporting process....
This dissertation is composed of readings of four novellas: two by the Swiss writer Gottfried Keller and two by the English novelist George Eliot. It focuses on the motif and concept of treasure (Schatz). Beginning with the figurative and rhetorical employment of "treasure" in the stories, each reading proceeds to...
Epstein-Barr virus (EBV) is a human gamma-herpesvirus that primarily infects B cells and epithelial cells. While the glycoproteins required for entry into these two cell types differ, the gH/gL glycoprotein complex is essential for entry into both epithelial and B cells. Analysis of gH protein sequences from three gamma-herpesviruses: EBV,...
This thesis comprises three essays addressing theory and evidence on the household response to tax-favored saving incentive schemes, with a particular emphasis on household risk taking. The US tax code and related regulatory institutions offer a variety of incentives to encourage US households to save and participate in risky investment...
Self-assembly is the process by which objects autonomously assemble into complexes. It is believed that self-assembly technology will ultimately permit the precise fabrication of complex nanostructures. Of particular interest are self-assembly systems that are highly programmable. That is, we can view a self-assembly system as analogous to a program, the...