CD1 molecules represent a class of antigen presenting molecules that present lipid antigens to cognate T cells. These molecules have been identified in all mammals examined so far. Unlike MHC molecules, which are highly polymorphic, CD1 molecules exhibit limited polymorphism and are divided in to two groups – 1 and...
How mental representations are constructed and how they evolve are central problems for cognitive science. Representation decisions help determine what computations are hard or easy. Structured, relational representations are a hallmark of human cognition. Developmental studies show that children do not perform as well as adults in tasks that require...
Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for characterizing molecular systems. It combines the chemical selectivity of vibrational spectroscopy with plasmonic signal enhancement to achieve the ultimate limit of detection--a single molecule. By overcoming the effects of ensemble averaging, single molecule SERS (SMSERS) probes distributions in molecular interactions and...
Organic photovoltaic (OPV) solar cells aim to provide efficient, flexible and lightweight photovoltaics (PV) with simple processing and low-cost. Advances in device optimization, structural and molecular design, as well as mechanistic understanding have helped increase device efficiency and performance. Within the framework of active layer optimization, systematically improving bulk heterojunction...
By 2020, there will be more than 200 billion sensor enabled objects world-wide in the Internet of Things (IoT). The biggest challenge of future IoT is to provide ultra scalable wireless access for a massive number of devices. The goal of this thesis is to build up a model for...
Worldwide, governments are beginning to take action to reduce anthropogenic CO2 emissions in order to mitigate the extent of global climate change. The largest fraction of global CO2 emission comes from electrical power generation, which is rapidly being converted to wind and solar installations. The intermittent nature of renewable resources...
The striatum is a subcortical nucleus that regulates a number of complex activities ranging from voluntary action selection to the subconscious formation of habit. The coordination of these operations is mediated by the principle cells of the striatum, spiny projection neurons (SPNs). SPN activity is dictated by a confluence of...
The FDA approvals of afatinib and ibrutinib in 2013 led to a heightened interest in cysteine-reactive covalent inhibitors. However, there are few methods to discover new cysteine-reactive inhibitors for enzymes for which reversible binding scaffolds are not known. To this end, we rationally designed a chemical system to attach a...
Even though renal blood flow accounts for nearly a quarter of cardiac output, the renal medulla operates in an environment with a scant supply of oxygen. The reason for this apparent discrepancy is thought to be threefold. Blood flow to the outer medulla is less than 50% of that received...
We argue that a country’s level of wealth inequality can be viewed as a reflection of the quality of its housing rental market. Using the ECB’s Household Finance and Consump- tion Survey (HFCS), we document that the aggregate homeownership rate and various measures of wealth inequality are negatively correlated across...