It's quite common for the novice musician to forget their place in the song, miss the change to a new section, or be unable to play in the key or at the tempo chosen by the leader. Every type of improvisational playing requires the player to follow a set of...
Part 1. The complex folded structures associated with RNA allow for specific protein-RNA interactions and also create binding sites for small molecules. Developing organic molecules that can bind RNA with high affinity and specificity is a challenge that must be overcome for RNA to be considered a viable drug target....
The classic error bounds for quasi-Monte Carlo approximation follow the Koksma-Hlawka inequality based on the assumption that the integrand has finite variation. Unfortunately, not all functions have this property. In particular, integrands for common applications in finance, such as option pricing, do not typically have bounded variation. In contrast to...
Motivated by applications to microfluidic separation systems like Capillary Electrophoresis (CE) and Capillary Electrochromatography (CEC), the research described in this dissertation analyzes through numerical and asymptotic methods the effect of variation in the wall zeta potential (or surface charge) on the electroosmotic flow field in a microchannel and the effect...
The extracellular matrix (ECM) is an environment rich in structural and signaling molecules, including growth factors and cytokines. Together, these signals are capable of changing cellular morphology and gene expression in response to extracellular environmental cues. Structural proteins in the ECM such as laminin transduce their signals through integrin receptors...
Bosnian women war refugees are not only trauma survivors, but are actively engaged in economic and social practices that shape their American sites of relocation. These economic activities--wage labor, and unremunerated volunteer and kin labor--are embedded in a moral framework of mutual obligation rooted in the concept veze / connections,...
Nature often uses reaction-diffusion(RD) as a means of making structures and materials of unique properties or morphologies on scales from macro- (e.g., stripes in zebras, tigers, and seashells, and formations in trees, agates, and rocks) to microscopic (e.g., cellular growth, chemotaxis and biological waves). However, reaction-diffusion phenomena have not yet...
The ready-mix concrete industry is a fascinating laboratory for the study of industry dynamics. Concrete plants produce a single homogeneous product with technology and equipment that has changed little over the last 50 years. Building a plant entails substantial sunk costs since the machinery used to produce ready-mix cannot easily...
This thesis concerns the development of robust algorithms for large-scale nonlinear programming. Despite recent advancements in high-performance computing power, classes of problems exist that continue to challenge the practical limits of contemporary optimization methods. The focus of this dissertation is the design and analysis of algorithms intended to achieve economy...
This dissertation studies two long-standing asset pricing anomalies: "Value and Growth Effects" and "Momentum Effects" via the channel of market imperfections. These market imperfections stem from basic information asymmetry problem, and take forms of contracting problems and less than perfectly competitive information intermediaries.
The first essay (joint with Zhi Da)...
This dissertation addresses the process-pathways running between immigrant adolescents' life experiences and their engagement in school by providing an ecocultural perspective on self-regulation. While the role of social context, such as stress and resources, has been identified as critical in its influence on different dimensions of adolescent development, research on...
Hypoxia is a reduction in the normal level of oxygen tension and occurs during acute and chronic vascular disease, pulmonary disease, and cancer. The key transcription factor that regulates the cellular responses to hypoxia is hypoxia-inducible-factor-1 (HIF-1). Understanding how HIF-1 is regulated is fundamental for understanding the biology of tumor...
The emergence of antimicrobial resistance and the growing concern to produce new drugs have influenced an increase in the amount of research directed towards the engineering of novel polyketides. The polyketide carbon backbone is synthesized by a set of enzymes known as polyketide synthases (PKSs). These catalyze the formation of...
Downsizings are now so pervasive that millions of Americans are laid off each year with the stated purpose of improving their organizations' financial outcomes. However, one of the unforeseen negative consequences of downsizings is high attrition by employees who "survive" the layoffs. This dissertation seeks to extend our understanding of...
Frictionless Information Systems (FIS) are a class of software systems that automatically bring users information and services related to what they are doing. These systems bridge the gap between the information a user wants and the repositories that contain the information - making the user more effective and informed. By...
The porphyrazines (pzs), a class of porphyrin derivatives, have shown potential as therapeutic and imaging agents due to a combination of their near-IR absorbance/fluorescence and their enhanced chemical flexibility. Cell viability/proliferation assays and fluorescence microscopy were carried out in both tumor and normal cells to characterize the biological activity of...
The detection of bio-molecules (e.g. nucleic acids and proteins) is the bedrock upon which research in the life sciences and diagnostic medicine rests. For nucleic acids, the polymerase chain reaction (PCR) is the ultimate in terms of target detection sensitivity (10s - 100s of copies/sample). For proteins, the enzyme-linked immunosorbent...
The study of granular matter is both scientifically intriguing and industrially important, yet it presents several unique characteristics and challenges. The discrete nature of granular materials often precludes the use of the continuum descriptions that are so commonly used for fluids, so alternative methods must be developed. Particles interact via...
Spontaneous regeneration in the adult mammalian central nervous system is rare, minimal, and generally does not lead to substantial functional recovery. Tissue engineering strategies to promote nerve regeneration aim to provide an environment that is physically and chemically engineered to enhance tissue formation. Strategic design of this environment is crucial...
The variable effects of self-awareness may be a result of multiple states of awareness being condensed under the umbrella term, "self-awareness". We posit that the cognitive and behavioral effects of self-awareness are largely dependent on another variable, level of abstraction, which modulates self-awareness on a continuum between conceptual and perceptual...
Since the beginning of the 21st century, the idea of building a Latin American musical discourse has returned to the artistic discussion, taking into account the peculiarities of cultural syncretism that manifest in the different countries of the region. From the most diverse aesthetics and through different musical media, a...
In the Western classical art music tradition, a high level of music performance is achieved at the intersection of a musician's emotional, cognitive, and physical processes. Expert classical musicians have both an aural imagining of the sound they intend to produce and the physical associations of what it feels like...
There are few concerns greater than those of a parent with an adult with an intellectual or developmental disability (I/DD). How is she or he going to be taken care of as she or he ages? The government provides services and support in the pursuit of care and services, but...
When navigating through space, the brain must integrate sensory information with past experiences to choose behaviors that are most likely to produce a positive outcome. Striatal medium spiny neurons (MSNs) expressing dopamine receptor 1 (D1) and dopamine receptor 2 (D2) receive sensory and motor information from cortical and midbrain regions...
It has been hypothesized that mindfulness-based programs with a primary focus on teaching self-compassion or empathy will have greater effects on self-compassion and empathy than will mindfulness-based exposure programs, which focus primarily on enhancing present moment awareness and reducing distress. However, because research on mindfulness-based exposure programs has centered on...
Over the last decades, there have been many changes in the business world that are associated with 52 percent of Fortune 500 companies either going bankrupt, being acquired by other companies, or ceasing to exist. One critical change is the transformation of the economy into a knowledge-based economy, where information...
In the Marvel Comics series Moon Knight, a mercenary believes an ancient Egyptian deity has brought him back from the dead so he can become the eponymous superhero. However, the mercenary’s symptoms of schizophrenia suggest he is instead simply suffering from a psychological break. From 1975-1999, Moon Knight stories used...
The goal of this research paper is to analyze concepts of armed conflict and peacebuilding from a gender perspective using a feminist epistemology approach.
I examine the impact of armed conflict on women, and the implications of women’s roles in armed conflict and in peacebuilding processes post-conflict. In doing so,...
Negative emotional behaviors, such as criticism, defensiveness, contempt, and stonewalling, that spouses may show during conflict are key predictors of marital dissatisfaction. Existing research has focused on middle-class couples, but little is known about how these negative emotional behaviors predict marital satisfaction among couples from socioeconomically diverse backgrounds. The present...
Standard narratives on the relationship between art and urban development detail art networks as complicit agents in processes of upscaling and gentrification connected to the political and economic elite. My thesis challenges the conventional narrative by investigating the relationship between grassroots art spaces, tied to local, community- based interests, and...
Patients with psychosis experience deficits in multisensory integration (MSI), or the communication between different sensory modalities, such as sound and sight. One way to assess multisensory integrations is by utilizing voice-pitch tasks in which participants hear the pitch of their own voice artificially altered by a computer. When healthy individuals...
Skeletal sexual dimorphism presents itself in humans primarily through the anatomical shape of the cranium and pelvis. However, some physical anthropologists maintain that climate could have an effect on human sexual dimorphism. Despite ongoing research pertaining to climatic effects on soft tissue or size dimorphism, little to no research has...
Previous research has shown that bodily gesture aids in learning words and is useful for musical expression. However, no studies to date have examined the use of gesture in learning words and music together. The original impetus for the present study was observing students with cognitive disabilities learn musical songs,...
With a large sphere of activity and ability to transfer data through wireless communication system, drones have proven to be more and more useful in both research and manufacturing. Whether by allowing researchers to collect measurements or filmmakers to attain aerial shots, the use of drone has allowed collection of...
In indoor environments, bacteria face selective pressure to carry antibiotic resistant genes (ARGs) from antimicrobial substances used in furniture, building materials, and personal care products. Humans rely on antibiotics to clear bacterial infections, so understanding the way in which these genes are transferred, i.e., on mobile genetic elements, is critical....
This study aims to advance our basic understanding of how we perceive objects in our environment. It’s unclear whether we understand object structure based on only how we perceive or on how it truly exists in the world. Examining eye-movements provides insight into how our visual system represents and understands...
Due to their ability to be engineered for specific cellular targeting, nanoparticles (NPs) have emerged as promising drug delivery vessels for immunotherapeutic and vaccination treatments. However, a major unsolved obstacle for cell-specific nanoparticle delivery is non-specific circulatory clearance by the mononuclear-phagocytic system(MPS). Comprised of various phagocytic cells, the MPS removes...
The bacterial CRISPR/Cas9 system shows promise as a genome-editing tool to treat human disease. It is integral to understand the binding and unbinding kinetics of Cas9 to its target DNA to study specificity of the Cas9 protein. Standard practices involve the use of negatively charged polymer Heparin to reduce unspecific...
Given any polyhedron in R3, we can cut it open along its edges, flatten it out, and obtain a polygon in the plane R2. In this project, we explored the opposite process, an open question that was first posed about 70 years ago: given a polygon in R2, what is...
Anxiety disorders are the most common group of mental illnesses in the United States and affect over 15% of the population. Prior work utilizing electroencephalogram (EEG) to investigate event-related potentials (ERPs) from the scalp has shown success in isolating certain neural correlates related to increased risk for developing anxiety disorders....
Posttraumatic stress disorder (PTSD) is an anxiety disorder characterized by flashbacks of the traumatic event and high comorbidity with major depressive disorder (MDD). Prior stress is known to increase the likelihood of developing PTSD after experiencing a traumatic event. Currently, PTSD is diagnosed clinically, its biological etiology is not known...
Expanding on research done on the mental health and happiness benefits associated with romantic relationships, this study investigates whether identity denial, the experience of being socially denied one’s chosen identity by having others refuse to acknowledge that identity, presents a challenge for bisexual people within committed romantic relationships. For straight,...
Physiological linkage (i.e., the covariation of moment-to-moment physiology between individuals) is thought to play an important role in relationship functioning. The present study examined physiological linkage across interbeat interval (IBI) and skin conductance levels (SCL) in a sample of married spouses (N=106) during both a pleasant and a conflict conversation...
"Prufrock" to <em>The Waste Land</em>: T. S. Eliot's Periodical Publications, 1915-1922 Randall J. Woods This dissertation presents, in publication date order, the 167 articles published by T. S. Eliot from 1915 to 1922, most of which have never been reprinted. They include literary criticism, book reviews, poetry, philosophical essays, humorous...