Fused polycyclic scaffolds with three-dimensional complexity from an array of stereocenters compose the core structures of countless natural product families with a variety of desirable biological activity. The development of synthetic methods and strategies to afford rapid access to these structures is essential to expose a wealth of untapped biological...
This dissertation is a mixed-methods study of municipal building inspections in Chicago. Existing literature demonstrates links between housing, urban governance, perceptions of dilapidated buildings, and racial and economic stratification. Less is known, however, about the intermediary actors who work at the nexus of on-the-ground interpretative processes and city-wide regulation. Building...
This dissertation provides an explanatory framework to explain the variations in battle-spaces, alternatively seen as wartime authority configurations across time and space. I place these variations along types of states along their functional dimension, and their respective forms of state power on the ground. I argue that these variations are...
This book has to do with the period in which Britain’s mandate in Palestine ended, the state of Israel was born, and the Arab refugee problem originated. Many historians have written on these matters, and many more will do so. I arrived in Haifa, Palestine, on 23 December 1947, and...
Understanding the chemical complexity of the extracellular matrix (ECM) and how chemical, biological, and physical cues bring changes to the behavior of cells has remained a grand challenge. Addressing these questions requires not only achieving systematic control over the interactions between cells and the ECM but also utilizing suitable analytical...
Organic Photovoltaic (OPV) materials are of great interest as a low-cost material the purposes of achieving wide spread, solar energy adoption. However, a limiting factor in materials development is the ability to proactively determine the active layer thin film morphology that largely informs device performance. Thus, understanding how materials design...
Organic Photovoltaic (OPV) materials are of great interest as a low-cost material the purposes of achieving wide spread, solar energy adoption. However, a limiting factor in materials development is the ability to proactively determine the active layer thin film morphology that largely informs device performance. Thus, understanding how materials design...
The increasing production and use of nanoscale transition metal oxide materials in the next generation of consumer electronics and electric vehicle batteries, specifically lithium intercalation compounds, may lead to environmental release and exposure, with poorly understood biological outcomes. As the toxicity mechanism of nanomaterials may vary fundamentally from their bulk...
While college attendance, persistence, and completion has consistently increased since the 1970s, increases in attainment were greater for students from high-income families compared their low-income counterparts. As a result, low-income students are the least likely to attend or complete college. While college costs and poorer academic preparation are often barriers...
To aid in the successful execution of goal-directed walking (discrete movement from a start location to an end target) the central nervous system forms a predictive motor plan. For the motor plan to be effective, it must be adapted in response to environmental changes. Despite motor planning being inherent to...
What sets this initiative apart is the commitment to deepening ties between African and non-African institutions and making them more seamless and routine. There is a need to make this case to US institutions - lobbying them to digitize/provide open access, creating relationships with African institutions, prioritizing partnerships and academic...
The neural crest is a unique, vertebrate specific stem cell population that gives rise to a diverse set of derivatives in the embryo, including sensory neurons, glial cells, melanocytes, and craniofacial structures such as cartilage, bone, and connective tissue. Unlike other multipotent stem cell populations present at this time, neural...
Immune checkpoint inhibitors have not been effective for immunologically “cold” tumors, such as prostate cancer, which contain scarce tumor infiltrating lymphocytes. We hypothesized that select tissue-specific and immunostimulatory bacteria can potentiate these immunotherapies. Here we show that a patient-derived prostate-specific microbe, CP1, in combination with anti-PD-1 immunotherapy, increased survival and...
Developing an interest in science, technology, engineering, and mathematics (STEM) is an important precursor to pursuing a STEM career. Given the United States’ relatively low standings in science and math compared to similar industrialized nations and its desire to be competitive in an increasingly STEM-based global economy, policy makers are...
Chapter 1 examines the question of how to sell a firm when potential buyers do not know how many other potential buyers there are. The seller can choose to sell the firm either through bilateral negotiations or through an auction. In equilibrium, if the seller observes the number of buyers...
This multi-study dissertation investigates the nature of musical independence in the instrumental large ensemble and the instructional practices that are used to foster its development. The dissertation is comprised of three separate papers, each addressing different aspects or approaches to the practice of independent musicianship in large ensembles. While each...
This thesis is naturally split into two parts. In the first part, we develop the theory of multi- linear algebra for Tate objects over exact categories endowed with an exact tensor product. We study all possible choices of tensor product and we give a geometric interpretation of the results. In...
This dissertation provides a socio-spatial account of black anarchism that emerges from a central concern with the practice of slaves’ jumps from the slave ship. It demonstrates how a substantive theoretical attention to these jumps generates possibilities for thinking about black radical politics differently. Through death, mobility, destruction, and escape,...
There is a shortage of research models that adequately represent the unique mucosal environment of human ectocervical tissue, which has limited the development of new therapies for treating infection or cancer. I hypothesized that engineering the microenvironment of ectocervical tissue with in vivo-like endocrine and paracrine support, would enable squamous...
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting approximately 1 in 10 reproductive-age women and remains the leading cause of female factor infertility among women of childbearing age. PCOS presents with features of hyperandrogenism, irregular menses and polycystic ovaries. Twin and family studies have demonstrated high heritability estimates...
In this thesis, we study arithmetic phenomena exhibited by polynomial dynamical systems on the projective line. Specifically, given a number field $K$, we are interested in the arithmetic of orbits of points $\alpha\in K$ under polynomials $\phi\in K[z]$. Given such a polynomial $\phi$ of degree $d\ge2$, we prove a lower...
This dissertation contains three chapters on two broad topics in labor economics: the determinants of early career outcomes and the impact of an aging population (and related policies). The first chapter investigates how the retirement slowdown among older Americans has affected the labor market prospects of younger Americans in recent...
This dissertation demonstrates how related initiatives to reform narcotics laws and protect consumers from dangerous medicines – taking hold in the 1950s and institutionalized in the mid-1960s – created the foundation for a massive expansion of federal policing of illicit drugs. Centered on the history of the Food and Drug...
The projected increase in the use of nanomaterials raises concerns about adverse impacts new technologies utilizing these materials may have on the environment. These concerns can be addressed from a chemical perspective by studying how emerging nanomaterials interact with biological systems. Fundamentally, the key interactions for nanomaterial uptake into a...
Sparked by the isolation of graphene in 2004, the research community has developed a family of 2D materials with distinct functionalities, enabling rapid demonstrations of entirely 2D devices with applications in energy, electronics, sensors and medicine. The desire to capitalize on the fantastic properties of 2D materials motivates ongoing efforts...
I describe a novel panel dataset on the U.S. primary care physician population, as well as the institutions and measurement strategies used to study physician behavior in the marketplace. I document several facts on primary care markets and supplier location decisions, the types of patients physicians accept, the scale of...
Marathons are long distance running events with many participants, often organized in heavily populated cities. A key component in marathon planning operations is the design of the marathon course to be followed during the race. In addition to the technical requirements regarding length and incline change, marathon courses must satisfy...
Anisotropic quasi-brittle materials represent a large group of geological and structural materials commonly seen in various engineering applications. A thorough study of their behaviors, especially anisotropic elastic response, damage, and fracturing behaviors, are essential for better understanding, optimizing, and utilizing their engineering performance. Two representative anisotropic quasi-brittle materials, shale rocks...
Noncentrosymmetry (NCS) is a requirement for many properties such as piezoelectricity, pyroelectricity, and nonlinear optical activity like second harmonic generation which are desirable for a variety of commercial applications. One method which has been employed to successfully synthesize NCS compounds utilizes acentric anionic groups, such as oxyfluoride metal complexes, as...
High-pressure and high-temperature laboratory experiments on the physical properties of mantle minerals provide a window into the Earth’s interior chemistry and geodynamics. The measurement of material density, compressibility, and elasticity at high P-T conditions provides thermoelastic parameters necessary to model seismic velocities in the Earth’s mantle at regional and global...
Endogenous growth theory has long recognized innovation as one of the key drivers of growth. Understanding what factors encourage or discourage innovative activities and how, in turn, these affect our communities is therefore crucial to inspire policies that promote inclusive growth. This dissertation tries to broaden our comprehension of the...
Dark matter represents one of the most sought after discoveries in physics, and leading theories predict that extremely low-background detectors could be sensitive to nuclear recoils from dark matter interactions. The PICO collaboration uses bubble chambers to look for the energy deposition from such an interaction. However, unknown backgrounds have...
This dissertation examines how the experience of migration and the context of reception influences religious ideas and practices. Using the experience of two branches of a Colombian Evangelical church, one in Miami, Florida and one in Madrid, Spain, I explore the extent to which context of reception and the experiences...
High-pressure and -temperature synthesis is a powerful tool for synthesizing new intermetallic compounds that cannot be formed using traditional solid-state syntheses. Such metastable compounds can exhibit unrivaled structural complexity, unique bonding, and unusual properties. In the simplest case, there are many binary systems in which no intermetallic compounds are known....
This dissertation explores human coordination in rhythmic, verbal, and spatial activity, and how coordination in one of these modes may subsequently impact behavior in another mode. My research examines what effects non-conversational actions have on the alignment of spatial perspectives during conversation. I hope to clarify how data about non-linguistic...
The availability and importance of data is accelerating, and our visual system is a critical tool for understanding it. The research field of data visualization seeks design guidelines – often inspired by perceptual psychology – for more efficient visual data analysis. Data visualization can borrow phenomena, tasks, and methods of...
Complex oxides show great potential for future devices as they offer functionalities beyond what can be delivered by conventional semiconductors. Among the complex oxides, the ABO$_{3}$ perovskite oxides are the most studied and engineered in the form of thin films and heterostructures. This thesis applies powerful synchrotron-based X-ray characterization tools,...
The follicle is the functional unit of the mammalian ovary and serves as a tightly controlled microenvironment where granulosa cells nurture the growth and maturation of the oocyte. Early events in follicular development are autonomous of the hypothalamic-pituitary-gonadal axis and are instead controlled by local factors that are used in...
In this paper, we show almost-Gelfand property of connected symmetric pairs (G, H) over finite fields of large characteristics by showing almost-sigma-invariant property of double coset H\G/H where sigma is the associated anti-involution combining with epsilon-version of Gelfand's trick
This dissertation shows how a group of novels–written by Peruvian born authors and published in the 20th and 21st centuries–have opened new perspectives about the impact of mass media in the Latin American literary system. I argue that XYZ (1935) by Clemente Palma, La tía Julia y el escribidor (1977)...
This dissertation analyzes figurations of gender and sexuality in Mexican modernista narratives that construct the modern subject. It discusses how these texts examine, interpret, and constitute subjects that were labeled as “degenerate” by medical, juridical, and criminological discourses in late nineteenth-century Mexico. Those ostensibly “scientific” and “objective” discourses reproduced and...
I study how electricity generation firms exert market power, raising price above marginal cost. Typical studies of market power in electricity markets focus on how firms sustain markups in the short-run energy market. I explore other channels electricity generation firms use to strategically maximize profits. First, I analyze strategic investments...
This dissertation explores the relationship between how teams form and what they need to perform. It adopts the perspective that technology is fundamental to organizing in modern workplaces and examines how technology may both enhance and constrain teamwork. By adopting this perspective, two questions naturally follow. First, how do teams...
Post-transcriptional gene silencing (PTGS) and, more specifically, RNA interference (RNAi) include the processes by which a small double-stranded RNA, 19 to 22 nucleotides (nts) long, negatively regulates the expression and/or translatability of a target RNA, which harbors reverse complementarity to that small RNA, by recruiting the so-called RNA-Induced Silencing Complex...
This dissertation studies the forces that drive the allocation of patients to hospitals in the United States. Even though it seems there is some market discipline in the hospital industry, we observe that many patients go to hospitals far from the quality frontier and we still do not have a...
Hybrid polymer-peptide conjugates are receiving increasing attention as a promising class of biomaterials. Polymer conjugated coiled-coil peptides are a new addition to these designer macromolecules. Even though a variety of experiments and computational simulations have shown stabilization of helices upon polymer conjugation, there are still many questions regarding the conformations...
The ability of a machine to synthesize textual output in a form of human language is a long-standing goal in a field of artificial intelligence and has wide-range of applications such as spell correction, speech recognition, machine translation, abstractive summarization, etc. The statistical approach to enable such ability mainly involves...