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- Description:
- Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus in these anatomical compartments and how and when the virus reaches those sites. To...
- Subject:
- Virology, Cellular biology, and Immunology
- Creator:
- Madden, Patrick
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15987 and etdadmin_upload_892041
-
- Description:
- With the rapid growth of demand for data center services, the energy and water use of data centers has become a critical concern in the contexts of energy use, climate change, and freshwater conservation. Therefore, understanding, quantifying, and optimizing the use of energy and water resources in data centers has...
- Keyword:
- Data Center, Data-Driven Modeling, Thermodynamics, Information Technology, Energy-Water Nexus, and Energy and Sustainability
- Subject:
- Statistics, Sustainability, and Energy
- Creator:
- Lei, Nuoa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15929 and etdadmin_upload_879204
-
- Description:
- Asymmetric relationships between creators and consumers in peer-produced knowledge repositories produce inequitable knowledge representation--or knowledge gaps. These gaps result in unequal access to information, and downstream technologies that leverage peer-produced data perpetuate these inequities. Effective knowledge gap identification represents a necessary first step towards equitable knowledge representation. However, while prior...
- Keyword:
- Social Computing, Human Computer Interaction, Computer Supported Collaborative Work, and Peer Production
- Subject:
- Computer science and Communication
- Creator:
- Maddock, Jim
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_879687 and http://dissertations.umi.com/northwestern:15938
-
- Description:
- This dissertation studies the limitations of incentive design in organizations and how they lead to inefficient outcomes. Chapter 1 studies how a coalition coordinates its members when they freely join and leave. It characterizes the conditions under which such coordination prevents the coalition from forming in the first place. In...
- Keyword:
- Performance Manipulation, Coalition Formation, Coalition, Delegation, Incentives, and Organization
- Subject:
- Management, Organization theory, and Economic theory
- Creator:
- Yan, Ruozhou
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16048 and etdadmin_upload_901237
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- Description:
- This dissertation contains three essays that study the operational challenges in healthcare-related fields. We strive to integrate analytical modeling and empirical methods to study decision-making under uncertainty for practice- and data-driven problems. We use large-scale datasets (millions) gathered from years of data collection. To gain access to these proprietary data,...
- Keyword:
- Healthcare, Resource Sharing, and Data-Driven
- Subject:
- Operations research
- Creator:
- Jiang, Yangzi
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_903140 and http://dissertations.umi.com/northwestern:16089
-
- Description:
- Enzyme substrate promiscuity has significant implications for metabolic engineering. The ability to predict the space of possible enzymatic side reactions is crucial for elucidating underground metabolic networks in microorganisms, as well as harnessing novel biosynthetic capabilities of enzymes to produce desired chemicals. Reaction rule-based cheminformatics platforms have been implemented to...
- Subject:
- Chemical engineering
- Creator:
- Ni, Zhuofu
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_883948 and http://dissertations.umi.com/northwestern:15963
-
- Description:
- Chimeric antigen receptor (CAR) T-cell therapies marry advances in cellular engineering with personalized medicine to provide patient-specific, targeted cancer treatments. Though current CAR T-cell therapies successfully target blood cell cancers, treating solid tumors has proven to be more challenging. Solid-tumor CAR designs must overcome several challenges, including tumor microenvironment barriers...
- Keyword:
- agent-based model, CAR T-cell therapy, social justice, anti-racism diversity equity and inclusion, computational biology, and engineering education
- Subject:
- Bioengineering, Education, and Chemical engineering
- Creator:
- Prybutok, Alexis Nicole
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16073 and etdadmin_upload_902739
-
- Description:
- Political stability is fundamental for economic development. Understanding the determinants and consequences of political stability is thus an important topic in development economics and political economy. This dissertation studies how political or economic instability influences economic development and, in turn, how economic factors influence political stability. In Chapter 1, I...
- Keyword:
- political stability, political economy, development economics, and economic history
- Subject:
- Economics
- Creator:
- Mueller, Joris Michael
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16026 and etdadmin_upload_900014
-
- Description:
- This thesis describes an exploratory project to develop a highly non-traditional approach to devise novel test methods for characterizing the properties of materials that are essential to the design of sustainable and resilient infrastructure, particularly naturally occurring materials such as soils and rocks. The central idea is that the material...
- Subject:
- Civil engineering
- Creator:
- Nally, Anastasia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16010 and etdadmin_upload_898203
-
- Description:
- Regardless of where refugees are hosted, they require political knowledge of rights, restrictions, responsibilities, and the governance actors and processes who decide and uphold these. This knowledge enables refugees to comply with national laws, benefit from rights and protections, avoid rights-based exploitations and harms, and pursue life with dignity in...
- Keyword:
- Refugee rights, Urban refugees, Uganda, and Political knowledge
- Subject:
- Political science
- Creator:
- Kuntzelman, Christa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_897615 and http://dissertations.umi.com/northwestern:16002