This thesis studies three approaches for solving linear programs with complementarity constraints (LPCC). The focus of Chapter 2 lies on difference-of-convex (DC) penalty formulations and the associated difference-of-convex algorithm (DCA) for computing stationary solutions of LPCCs. We concentrate on three such formulations and establish connections between their stationary solutions and...
This dissertation consists of two papers united by a common element: they both study the behavior of heterogeneous agents across the business cycle.
In Chapter 1, I consider: what is the link between the drop in consumer credit during the Great Recession and increased unemployment? I build a heterogeneous household...
This dissertation examines the construction and regulation of over-the-counter derivatives markets before and after the 2007-2009 global financial crisis. It addresses two questions: How did the market for derivatives traded outside traditional exchanges grow so large and crisis-prone with so little public regulation? And, why, given derivatives’ contribution to the...
Digital behavior change interventions (e.g., mHealth, websites, behavior change apps) can be an effective way to engage groups who experience disadvantages in terms of social and economic attainment, with tailored health content and have potential to improve health outcomes and reduce health disparities. Given the importance and pervasiveness of behavior...
Regulatory T (Treg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumor immunity. Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of proinflammatory properties, can promote autoimmunity and/or facilitate more effective tumor immunity. A comprehensive understanding...
The leptonic and inclusive hadronic decay branching fractions of the W boson are studied using 35.9 $fb^{-1}$ of proton-proton collision data collected at $\sqrt{s}=13~TeV$ during the 2016 run of the CMS experiment. Events characterized by the production of pairs of W bosons from \ttbar and \tW processes are selected. Multiple...
This project would not have been possible without the support and guidance of my supervisor, Emma Elizabeth Ilett. Emma helped me establish the specific research question and structure of the study. She also assisted with statistical analysis, provided helpful advice during each step of the project, and taught me so... and Hematopoietic stem cell transplantation (HSCT) recipients receive pre-transplantation treatment regimens varying in conditioning intensity and antibiotic administration. Broad-spectrum, antianaerobic antibiotics have the potential to disrupt the normal gut microbiome balance and reduce immune function. We aimed to retrospectively examine the impact of pre-transplantation conditioning and antibiotics on rates of mortality,...
Chagas heart disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is still regarded as a major public health problem in Central and South America. The finding of cardiac specific autoimmunity during infection in both humans and experimental animals has provided a basis for investigation of its potential role...
A stroke occurs when blood flow in the brain is impaired and often causes damage to corticospinal tract projections that control the muscles of the upper-extremity. Due to this damage, 50-70% of stroke survivors experience long-term upper-extremity functional deficits(Faria-Fortini, Michaelsen, Cassiano, & Teixeira-Salmela, 2011). These deficits result from motor impairments...
Background: The tripartite model (Clark & Watson, 1991) has been used to represent the substrates of general distress in both depression and anxiety (Negative affectivity [NA]), while also characterizing specific features of decreased positive affectivity (PA) in depression and increased physiological hyperarousal (PH) in anxiety. Core affect characterizes affect by...