Introduction
To assess disparities in retesting for glycated hemoglobin (HbA1c) and systolic blood pressure (SBP) among people with diabetes mellitus (DM) and hypertension (HTN), respectively, we analyzed medical records from a lesbian, gay, bisexual, transgender, queer-specialized federally qualified health center with multiple sites in Chicago.
Research design and methods
We...
An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at... and Miriam Felton-Dansky’s Viral Performance proposes the concept of the viral as an essential means of understanding socially engaged and transmedial performance practices since the mid-twentieth century.
Kai Evers’s Violent Modernists: The Aesthetics of Destruction in Twentieth-Century German Literature develops a new understanding of German modernism that moves beyond the oversimplified dichotomy of an avant-garde prone to aggression on the one hand and a modernism opposed to violence on the other. Analyzing works by Robert Musil, Franz... and An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at...
The Unfinished Art of Theater: Avant-Garde Intellectuals in Mexico and Brazil shows how theater was a key site in the struggle to redefine the relationship between art and social change and the rise of an international avant-garde in both nations from 1917 to 1934. and An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at...
An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at... and In her provocative book, Brooke Kroeger argues for a reconsideration of the place of oft-maligned journalistic practices. While it may seem paradoxical, much of the valuable journalism in the past century and a half has emerged from undercover investigations that employed subterfuge or deception to expose wrong. Kroeger asserts that...
An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at... and Intervening in the multidisciplinary debate on emotion, Tropes of Transport offers a fresh analysis of Hegel’s work that becomes an important resource for Pahl’s cutting-edge theory of emotionality. If it is usually assumed that the sincerity of emotions and the force of affects depend on their immediacy, Pahl explores to...
Time and the Shared World challenges the common view that Heidegger offers few resources for understanding humanity’s social nature. The book demonstrates that Heidegger’s reformulation of traditional notions of subjectivity has wide-ranging implications for understanding the nature of human relationships. Irene McMullin shows that, contrary to entrenched critiques, Heidegger’s characterization... and An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at...
An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at... and Victoria Aarons and Alan L. Berger show that Holocaust literary representation has continued to flourish well into the twenty-first century—gaining increased momentum even as its perspective shifts, as a third generation adds its voice to the chorus of post-Holocaust writers. In negotiating the complex thematic imperatives and narrative conceits of...
Theaters of Citizenship investigates independent Egyptian performance practices from 2004 to 2014 to demonstrate how young dramatists staged new narratives of citizenship outside of state institutions, exploring rights claims and enacting generational identity. Using historiography, ethnography, and performance analysis, the book traces this avant-garde from the theater networks of the... and An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at...
Shakespeare's Legal Ecologies examines the key role that the law and legal frameworks played in the ways Shakespeare explored character and selfhood. and An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at...
Screening Auschwitz is the first and definitive discussion of the classic Polish Holocaust film The Last Stage (Ostatni etap). Directed by Auschwitz survivor Wanda Jakubowska, The Last Stage was the first film of its kind. Marek Haltof has incorporated a wealth of new sources to trace the creation of this... and An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at...
Privately Empowered responds to the lack of adequate attention paid to Islam in Africa in comparison to Islam in the Middle East and the Arab world. Shirin Edwin points to the tight embrace between Islam and politics that has rendered Islamic feminist discourse historically and thematically contextualized in regions where... and An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at...
An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at... and A groundbreaking essay collection that pursues the rise of geoculture as an essential framework for arts criticism, The Planetary Turn shows how the planet—as a territory, a sociopolitical arena, a natural space of interaction for all earthly life, and an artistic theme—is increasingly the conceptual and political dimension in which...
In The Philosophical Structure of Historical Explanation, Paul A. Roth resolves disputes persisting since the nineteenth century about the scientific status of history. He does this by showing why historical explanations must take the form of a narrative, making their logic explicit, and revealing how the rational evaluation of narrative explanation becomes possible. Roth... and An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at...
Perception in Aristotle's Ethics seeks to demonstrate that living an ethical life requires a mode of perception that is best called ethical perception. Specifically, drawing primarily on Aristotle’s accounts of perception and ethics in De anima and Nicomachean Ethics, Eve Rabinoff argues that the faculty of perception (aisthesis), which is... and An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at...
An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at... and Focusing on Stendhal, Gérard de Nerval, George Sand, Émile Zola, and Marcel Proust, The Novel Map: Mapping the Self in Nineteenth-Century French Fiction explores the ways that these writers represent and negotiate the relationship between the self and the world as a function of space in a novel turned map.
Muslims in Kenyan Politics explores the changing relationship between Muslims and the state in Kenya from precolonial times to the present, culminating in the radicalization of a section of the Muslim population in recent decades. The politicization of Islam in Kenya is deeply connected with the sense of marginalization that... and An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at...
Montaigne’s Essays are rightfully studied as giving birth to the literary form of that name. Ann Hartle’s Montaigne and the Origins of Modern Philosophy argues that the essay is actually the perfect expression of Montaigne as what he called "a new figure: an unpremeditated and accidental philosopher." Unpremeditated philosophy is... and An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at...
What makes some characters seem so real? Mimetic Lives: Tolstoy, Dostoevsky, and Character in the Novel explores this question through readings of major works by Leo Tolstoy and Fyodor Dostoevsky. Working at the height of the Russian realist tradition, Tolstoy and Dostoevsky each discovered unprecedented techniques for intensifying the aesthetic...
Cite this article: Shen, J., McFarland, A.G., Blaustein, R.A. et al. An improved workflow for accurate and robust healthcare environmental surveillance using metagenomics. Microbiome 10, 206 (2022). https://doi.org/10.1186/s40168-022-01412-x and Background: Effective surveillance of microbial communities in the healthcare environment is increasingly important in infection prevention. Metagenomics-based techniques are promising due to their untargeted nature but are currently challenged by several limitations: (1) they are not powerful enough to extract valid signals out of the background noise for low-biomass samples,...
Contemporary Ethiopian is, without question, facing enormous challenges. At the core of these challenges lay a state-building process major constituencies and elite groups were either alienated from, forced to acquiesce to, or coopted into. Unable to derive political legitimacy from democratic participation, successive governments largely relied on coercion and neopatrimonialism,...
In an assault on artistic freedom, the Nazi Government attempted to isolate, discredit, and ban musical works of Jewish composers by labeling them “Entartete Musik,” or “Forbidden Music.” After the Nazis seized power in 1933, the government disparaged and condemned works of Felix Mendelssohn and Gustav Mahler along with works...
Protein-protein interactions are ubiquitous in living systems, and mediate important cellular processes from decision making to immunity against pathogens. Furthermore, protein-protein interactions are key to many protein therapeutics, pathogen diagnostics, and numerous synthetic biology applications. As a result, there has been significant effort to develop methods to express potential protein...
In 2009, the Health Information Technology for Economic and Clinical Health Act (HITECH) promoted national use of electronic health records (EHR) in the US by giving incentives to providers who adopt ‘meaningful use’ of EHRs. As of 2017, nearly 86% of office-based physicians had adopted EHRs. EHRs have rich information...
Preterm birth (PTB) is the leading cause of infant morbidity worldwide. Approximately 380,000 babies are born prematurely in the USA every year. Estrogen (E2) and progesterone (P4) play essential roles during pregnancy and labor; a clear understanding of their action mechanisms, however, is lacking. E2 and P4 function by activating...
This dissertation examines anti-Black race-based ideologies prevalent in early American musical theatre through a multi-faceted case study concerning Morgan Benson, a child actor of the early musical theatre stage, Target Parades of the long nineteenth-century, and The Black Joke. This is an excavation project, seeking to unearth conceptual underpinnings for...
Nuclear receptors (NRs) are an important family of transcription factors that often regulate genes in response to ligands and by way of direct interactions with coactivator proteins. Many NR-coactivator pairs have been identified that cooperate to regulate transcription but fully understanding how NRs recruit specific coactivators involves learning which of...
Research over the past several decades has revealed that memory reactivation in sleep contributes to the formation of long-lasting memories. Among the most recent developments in this field is the widespread use of the technique of targeted memory reactivation (TMR), which allows researchers to induce reactivation of specific memories during...
Contemporary decolonial criticism and critical phenomenological thought may be characterized as proceeding from a disenchantment with the philosophical aspiration towards universality. The overarching argument put forward in this dissertation is that there is, to the contrary, an intimate and even necessary connection between the decolonization of philosophy and the affirmation...
New capabilities in x-ray microscopy have been enabled by rapid advances in synchrotronlight sources and in high performance computing. We present here conceptual and computational
advances in two areas of x-ray microscopy. One involves ptychography, where computation is
used to obtain images from diffraction patterns as a finite coherent illumination...
Polymer and polymer/ceramic composites known as bone cements are commonly used in musculoskeletal reconstructive surgeries where bone tissue fixation, reinforcement, or void filling may be needed. Polymethylmethacrylate, PMMA, was the initial (and currently only) FDA-approved bone cement for bone-void filling applications yet faces many inherent material-based challenges that impacts its...
This dissertation analyzes how suburban school districts made sense of and planned to reduce inequality between 2019–2021. Previous literature has found that suburban schools, despite their reputation as the best in the country, are deeply unequal (Lewis and Diamond 2015; Lewis-McCoy 2014). Building on this previous scholarship, I ask: How...
Rising social inequality across economic, gender, and racial lines is a pressing issue of our time. Despite widespread agreement that inequality exists, there are stark ideological disagreements about its extent, its victims, and about what – if anything – should be done to address it. Prior work demonstrates that the...
Photochemistry is an inherently interdiscplinary field where very large energies are leveraged for the making and breaking of bonds. My work has broadly dealt with various strategies to control how energy delivered by light can be channeled into useful functions. I developed a strategy to control the chemo- and stereo-selectivity...
Breakthroughs in large-scale biological data collection have resulted in a wealth of -omics (genomics, metabolomics, etc.) datasets in the literature. However, the development of appropriate computational techniques for their analysis is lacking, yet crucial for fully extracting the rich information contained in these datasets. The work in this dissertation describes...
Cuteness is a popular aesthetic in product design, yet there is a lack of understanding of who is most likely to engage in cute consumption and, more importantly, why. In this dissertation, I consider the role of sex and gender identity in cute consumption, proposing a strong mental association between...
The answer to the question “Why do we sleep?” lies in understanding the biological underpinnings of homeostatic drive to sleep. Wakefulness is correlated with numerous changes in brain activity, structure and gene/protein expression that re-normalize following sleep however which of these elements is sufficient to cause sleep drive and how...
Perturbations to the physiology or impairments in the formation of synapses within the cochlea, specifically the ribbon synapses, result in decreased sensitivity to auditory stimuli. In example, prolonged exposure to moderately intense auditory stimuli, like power tools, can result in the swelling of nerve terminals, retraction of the postsynaptic membrane,...
The provision of social services is becoming increasingly complex as human service agencies, nonprofits, and government agencies recognize the importance of wraparound care. A wraparound approach to social service provision acknowledges the importance of providing comprehensive services that meet various individual, family, and community needs. This approach is enacted through...
Electrical spinal cord stimulation is an emerging treatment for spinal cord injury that can improve walking and bladder control, among many other functions. While the anatomical location of the motor pools for muscles involved in locomotion in the lumbosacral cord has been identified, the map of the functional output of...
For some inducible genes, the rate and molecular mechanism of transcriptional activation depend on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation, and requires both changes in chromatin structure and recruitment of poised RNA polymerase II (RNAPII) to the promoter. A well-established model for...
This dissertation contains two topics. The first topic focuses on how to use information design to minimize costs of implementing a policy that guarantees 100% passing rate of all participants by providing enough compensation for the their effort. The second topic explores an auction setting which involves financially distressed business...
Listeners can experience strong and often positive identification with music. Contemporary research has emphasized the importance of a listener’s own identity, including their sense of self and their desires, when forming such identifications. However, acknowledgments of the listener’s role in the listening experience have failed to productively engage discussions of...
Organic photovoltaics offer an opportunity to make solar cells more affordable and widely accessible using cheap, solution-processable light-absorbing layers. In order to realize new technologies, a fundamental understanding of organic chromophore photophysics is required to overcome efficiency limitations. Throughout this doctoral work, I investigated the kinetic and physical characteristics of...
This thesis develops novel methods for generating space-filling designs inside a designspace and subsampling from a data set. It incorporates materials from two papers by the
author: Shang and Apley 2021; Shang, Apley, and Mehrotra 2022a. Chapter 1 discusses space-filling designs of computer experiments, which is publishedas Shang and Apley...
People are exposed to inaccurate claims and ideas every day, from sources intended to inform, entertain, or do both. A large body of research has demonstrated that exposure to inaccurate statements, even when conveying obviously false ideas, can affect people’s subsequent judgments. Contemporary accounts suggest that these effects may be...
In this document, I demonstrate that: 1) Linear basis functions cannot outperform nonlinear ones to represent hand kinematics 2) Nonlinear autoencoders outperform PCA on the dimensionality reduction of hand kinematics, 3) Nonlinear autoencoders outperform PCA in human gait representation and recurrent nonlinear autoencoders can seamlessly express the temporal dynamics, 4)...
My dissertation defends a hermeneutic conception of ideology and its critique that situates both in the world-disclosing function of language.I argue that we must conceive of ideologies as world-disclosing embodied interpretive schemas insofar as they guide our cognitive, affective, and conative access to reality by providing the background knowledge, meanings,...
This thesis contains two research projects. The first research project examined the coherent nature of electron transfer in two donor-acceptor dyads – one single acceptor control compound and one dual acceptor molecule of interest. Using transient absorption spectroscopy in the ultraviolet/visible/near-infrared and mid-infrared regions, magnetic field effect experiments, and theoretical...
This dissertation considers how 21 trans and queer teenagers learned to create livable lives in unlivable worlds through routine participation on social media. Through a multi-year partnership with an interdisciplinary gender program in Chicago, I employed a humanizing qualitative design anchored by interview and participatory visual methods over three nested...
Advances in methods to sequence and manipulate DNA have enabled systems that enzymatically encode information in cellular DNA in situ. These systems, broadly categorized as molecular recorders, couple signals of interest to the expression of DNA modification enzymes, resulting in signal-dependent changes in DNA sequence. While a variety of molecular...
Persons with spinal cord injuries can use state-of-the-art brain-computer interfaces to control robotic arms. Despite this high-tech solution, their movements are slow and imprecise, much like those made by individuals who have lost proprioception, the sense of body position and movement. Intracortical microstimulation (ICMS) used to reactivate neural circuits in...
This dissertation studies the integration of analytical modeling and optimization, machine learning, and Bayesian learning to optimize cost, access, and quality of healthcare delivery. Chapter 1 models computer-aided triage (patient prioritization) as feature-based priority queuing where types (diseases) are not perfectly observed but are inferred from observed features using a...
ABSTRACTFor several decades, dams have played an essential role in human development. In many low-and middle-income countries (LMICs), the construction of dams remains an integral part of industrialization and modernization. However, dam construction and associated infrastructure have significantly contributed to socioecological destruction and population displacement. For example, the construction of...
Protein-based biomaterials are widely used in biomedical applications and mechanical support because of their novel structural flexibility, biocompatibility and mechanical properties. Protein-based biomaterials outperform traditional synthetic materials in various environments as traditional materials lack the diverse chemical functionalities that proteins offer. Novel bioinspired techniques such as directed evolution offer the...
Conventional polymer networks are composed of strong, fixed covalent cross-links. The covalent cross-links render polymer networks with outstanding mechanical properties, heat stability, and chemical resistance; however, they also prevent polymer networks from being decross-linked or/and recycled into similar-value products at the end of their life, leading to environmental and economic...
Memory management and address translation need significant optimizations in order to not behindrances in the near future. Currently, plenty of work has started to address issues within the
current abstraction of the hardware-software codesign of paging. I argue that a new abstraction
is needed in order to properly address this...
Van der Waals, or layered, materials offer a flexible platform to tune properties via exfoliation down to the single- or few-layer limit; they are at the forefront of cutting-edge materials science and engineering research because of the innumerable ways to tune materials as a function of thickness or composition. Due...
The worldwide community of patients affected by Basal Cell Carcinoma of the skin (BCC) is larger than that of any other cancer. While BCC is rarely lethal, currently available treatment strategies often leave patients with disfiguring scars on their faces, heads, and necks. Moreover, the high recurrence rates of BCC...
Granular materials consisting of discrete particles, are a pervasive material in nature and play a major role in disparate fields of science and technology. To control and manipulate the granular materials in engineering, enriching our understanding of their fundamental characteristics and mechanical behavior is crucial. In this context, one of...
Optical coherence tomography (OCT) images the retina noninvasively with micrometer-scale volumetric resolutions. It is an invaluable resource in the clinic for identifying, monitoring, and treating blindness-causing diseases. By shortening illumination wavelengths to the visible range, visible-light OCT (vis-OCT) improves image resolution, provides new scattering contrasts, and enables oxygen saturation (sO2)...
In recent years, machine learning on graphs (or networks) has gone from a niche topic with only a few active researchers worldwide, to a heavily invested field with novel use cases for dealing with relationships and/or interactions within complex systems in the natural and social sciences. Traditionally, choosing the right...
This dissertation examines the remediation of video game music from their source games to the concert hall. I argue that while not unique in their repositioning from popular to classical registers, the classicalization of video game music offers a contemporary challenge to the current norms of classical music institutions. I...
Chromatin is the biological material that packages our genetic information. In humans, 2 meters of linear DNA is compacted into an approximately 6 μm nucleus. Our DNA is transcribed into RNA, which is then translated into proteins. Cellular phenotype, the composite of all cellular functions, is defined by the entire...
Affect represents a major domain of human consciousness, consisting of a complex group of psychophysiological processes to drive human behavior. Many genetic and environmental factors may cause dysregulation of affective states, resulting in disorders that severely disrupt normal cognitive function and diminish the quality of life. Transitions among affective states...
Before initiating a walking movement, the central nervous system forms a motor plan, a set of motor commands predicted to accomplish task-specific goals. To be effective, motor plans must be continually updated to consider an ever-changing external environment. Despite being an inherent part of walking, how the nervous system adapts...
The overall goal of this dissertation, comprised of three empirical studies, was to examine the role of social support as a source of resilience in the face of two chronic stressors: low socioeconomic status and first-generation college student status. Study 1 of this dissertation sought to examine neighborhood support from...
Today’s romance fiction landscape is drastically different than the early 1980s when its community of readers and writers formalized in the Romance Writers of America and Romantic Times fan magazine. Then, romance fiction was understood to focus on “the interaction between male and female.” Today, romance depicts a variety of...
Autism spectrum disorder (ASD) is a heritable, neurodevelopmental disorder characterized by social impairments and restricted and repetitive behaviors (American Psychiatric Association, 2013; Tick, Bolton, Happe, Rutter, & Rijsdijk, 2016), with a subset of first-degree relatives demonstrating a constellation of subclinical traits that are qualitatively similar to the defining features of...
Three in ten people worldwide lack access to a safely managed source of drinking water, with one in ten lacking access to a drinking water service altogether. This is projected to worsen in the coming years as climate change, infrastructure degradation, and poor governance work to further increase global water...
The creative process of an artistic work is a space, figuratively, in which every facet of our personal lives has an effect and, in turn, can be explored and altered. One of the most fundamental aspects of life, be it human or not, is the way in which one relates...
Imagine sitting in a room listening to some friends play a song. Perhaps one friend is playing guitar, another playing bass, and a third is playing drums. The musical content in this scene is extraordinarily complex, yet it contains many types of structure that is easy for us to comprehend....
The purpose of this thesis is to derive three results in probability theory. The first is a proof that small powers of the normalized absolute characteristic polynomial of a random matrix sampled from either the Gaussian Orthogonal or Symplectic Ensemble converges in law to a Gaussian multiplicative chaos measure. The...
In this dissertation, I provide insight into different aspects of the law and politics of trade secrecy at four levels of analysis. Part I examines trade secrecy from an international and comparative perspective. It encompasses Chapters 2 and 3 and focuses on (#1) international law and (#2) comparative national policy....
The current view in neuroscience holds that the brain, together with its sensory and motor structures and the environment, form a closed-loop system – a sensorimotor loop – in which the brain receives information from the environment and converts it into a motor response while simultaneously making predictions about future...
While there is high demand for university computer science (CS) courses, students often struggle when learning to program. Prior work has identified that student perceptions of their programming ability may contribute to these challenges. For example, studies show that students often perceive that they do not belong, are not capable...
This dissertation is a case study of one midwestern city and its Latinx inhabitants. It explores the intertwined pursuit by ethnic Mexicans and Puerto Ricans of inclusion in union and electoral politics. The world of machine politics offered ethnic Mexicans and Puerto Ricans an avenue for inclusion. Central to this...
Visual Question Answering (VQA) increasingly attracts industry and academia attention. It requires the model to provide a natural language answer by an image and a related natural language question. Meanwhile, it relates to multidisciplinary research such as natural language understanding, visual information retrieval, and multimodal reasoning. As a multimodality task,...
Originally motivated by the emergence of networked systems lacking central coordination such as multiprocessors, wireless sensor networks and smart grids, the study of distributed optimization algorithms has been an active field of research spanning multiple decades. More recently, the rapid growth in the availability of high-dimensional datasets has posed the...
This dissertation assesses the relationship between inequality and the longevity of urban communities. It does so through an examination of low-status households, a population segment I term Urban Commoners, at the ancient Maya city of Aventura, Belize. Aventura was a socioeconomically diverse urban center that grew to its peak in...
Vimentin intermediate filaments (VIFs) provide mechanical integrity to cells and serve as markers of tissue origin and cell differentiation. Several non-mechanical roles for vimentin have recently been reported, including regulation of key pathways that control cell growth, cell signaling, and cell motility. Here, I present the role of vimentin in...
In reinforcement learning (RL), an agent aims to learn the optimal policy by interacting with the environment and collecting the reward for each action taken. With the aid of strong function approximators such as the neural networks, RL achieves tremendous empirical successes in various scenarios, including game playing \citep{silver2016mastering, silver2017mastering},...
In this dissertation, we aim to develop algorithms that achieve optimality with provable complexity guarantees under various settings in reinforcement learning (RL). Specifically, in Markov decision processes (MDPs), we study single-agent and multi-agent online RL, respectively, and offline RL under the presence of unobserved confounders. Single-agent online RL. We design...
Laser powder-blown directed energy deposition (DED) is an additive manufacturing process that utilizes a co-axial nozzle and laser to melt metal powders onto a substrate in a line-by-line fashion. This coupling gives rise to interactions between the laser, powder, and melt pool. To address fundamental process understanding, physical models were...
This thesis presents a new self-assembling robotic system that diverges from traditional approaches by enabling robots to build structures not constrained to a lattice and formed based on environmental conditions, rather than on a priori blueprints. Robot self-assembly is a class of behavior in swarm robotics in which many robots...
Sea urchins are virtuosi of biomineralization, the process by which organisms build mineralized tissues. The embryonic animal exemplifies this with the formation of its endoskeletal spicule. The primary mesenchyme cells (PMCs) undertake spicule synthesis, which involves deposition of the initial granule, elongation of the spicule, and several choreographed changes...
Slow-moving landslides are common in mountainous area worldwide. Most of them mobilizes slowly over long periods of time, which causes continuous damage to proximal infrastructure and habitats. Most notably, some slow-moving landslides can experience catastrophic acceleration at some point in their life cycle, with potentially fatal consequences. It is therefore...
Over the course of disease progression, half of adults with type II diabetes also develop diabetic peripheral neuropathy (DPN), peripheral nerve damage precipitated by the downstream metabolic effects of hyperglycemia, insulin resistance, and dyslipidemia. This multifactorial pathogenesis of DPN leads to various structural and physiological changes within the nerve, ultimately...
This dissertation explores the mathematics identities of early elementary school students. Throughout school, many students come to believe that mathematics is not for them or is not a part of who they are or want to be. Previous research has revealed mechanisms that lead to negative relationships with mathematics for...
This multi-study dissertation explored technology and creativity within three different technology-rich creative musical spaces. Through the use of three contrasting empirical methods (qualitative content analysis, intrinsic case study, and phenomenology), I explored the complex ways technology and musical creativity are linked. In the first study, I completed a content analysis...
The field of time-domain astronomy has seen significant advancements in the latest years as increasingly sensitive, deep and wide-field surveys of the sky at all wavelengths are being carried out more and more frequently. Furthermore, the addition of gravitational wave detectors around the world has opened an entirely new window...
X-ray imaging at nano and micro-scale is of great importance for the material science and defense industry. Large penetration depth and low wavelength of x-rays offer an important potential to image objects at high resolution and in a non-invasive process. While the ever-growing community is pursuing novel applications and looking...
