This book discusses how cities that have developed through the successive stages of capitalism should transform themselves when adapting to the conditions of the contemporary global age. Since modern times, the capitalist economy has largely defined society, politics, and environment—this has casued the collapse of communities, the crisis of democracy,...
The intersection of sound design and music scoring has been employed expressively in contemporary Mexican cinema to convey complex social commentary. This dissertation investigates how the Mexican films Vuelven, Sin Señas Particulares, and Sanctorum exploit the potentials of the soundtrack to create politicized aesthetic experiences. My research is in dialogue...
Sentence comprehension requires both syntactic prediction and working memory processes. Evidence suggests that both are impaired in agrammatic aphasia, and can independently contribute to comprehension breakdowns, but the relationship between them, especially during real-time sentence comprehension remains unclear. Two EEG studies investigated on-line processing of sentences with non-local long-distance dependencies...
The commitment of resources to coaching almost always occurs in interaction with other district-wide efforts to improve instruction. Given this probable situation, it’s concerning that the field lacks the ability to provide guidance regarding how coaches might reasonably be integrated within overall plans for the coordination and improvement of instruction....
Tissue-infiltrating neutrophils (polymorphonuclear neutrophils [PMNs]) are a prominent feature of inflammatory bowel disease (IBD) and colorectal cancer (CRC), where these immune cells can promote cytotoxicity or exacerbate disease outcomes. We recently showed that in acute colon injury, PMNs can increase DNA double-strand break (DSB) burden and promote genomic instability via...
In the United States, allergic disease affects approximately 60 million people and impacts more people every year. While prevalence of allergic disease has steadily increased, there has concurrently been an increase in rates of metabolic syndrome—characterized by increased abdominal girth, decreased sensitivity to insulin, and higher levels of circulating blood...
Facts are not enough! The more recent wave of science communication practices have been advocating for the death of the deficit model of science communication. This model notes that by possessing sufficient information, individuals will change their attitude and behavior to align with scientific facts. However, recent research has shown...
This paper discusses the role of the Secondary Rainbow Synthesizer in Catherine Lamb’s composition Prisma Interius IX. This instrument is a MIDI keyboard that controls a computer program consisting of a bank of resonant band-pass filters, which are tuned to specific frequencies and can be opened or closed to varying...
Biomedical imaging is an essential part of medicine that enables the non-invasive observation of biological phenomena. This, in turn, allows for more accurate and earlier diagnoses, monitoring of therapies, and even fundamental research into biological processes. Molecular imaging, a fast-growing subdiscipline of biomedical imaging, seeks to image biochemical processes at...
Otoacoustic emissions are currently used for various clinical purposes; however, stimulus frequency otoacoustic emissions (SFOAEs) evoked using a single one are not utilized clinically due to uncertainties regarding their generation mechanism, their spatial source(s) in the cochlea, and their susceptibility to various cochlear insults, particularly in humans. Over the years,...
Emergent phenomena are phenomena that only arise from the bulk collective, not from individual pieces of that collective. The design of materials which host emergent phenomena can be achieved by controlling the interactions between constituent atoms, ions, or electronic spins in a material, and include materials such as permanent magnets...
Rocky exoplanets are indicated to be common in the galaxy. Future instruments including the {\it James Webb Space Telescope} (JWST), high resolution ground-based spectrographs, and direct imaging missions for under consideration by the 2020 Decadal Survey on Astronomy and Astrophysics are poised to unlock the atmospheres of habitable zone planets...
In the adult hippocampus of many mammalian species, populations of newborn dentate granule cells (DGCs) are continuously generated and undergo subsequent activity-dependent neuronal maturation and incorporation into the preexisting hippocampal circuitry. Increasing evidence has demonstrated that these young adult-born DGCs (abDGCs) participate in numerous cognitive and affective processes such as...
RNA viruses cause a wide range of diseases that range from mild respiratory illness to fatal hemorrhagic fevers. To combat these pathogens, most cells in the human body scan the cell for viruses and activate a potent cell-intrinsic immune response by producing interferon (IFN), a cytokine that amplifies the innate...
Part I: Evaluating the relationship between Crosslink Kinetics and Thermodynamics with the hydrogel mechanics. The past two decades have witnessed a surge of applications built upon dynamic covalent chemistry (DCC), both attributed to the scope of developed reactions as well as their modularity.1-3 These reactions have comparable strengths to their...
This dissertation is a culmination of work spanning several modes of travel, multiple datasets, and different contexts. Because the proliferation of new mobility services disrupted the transportation ecosystem, I aim to understand travel behavior and investigate how new and traditional modes intermingle. I focus my attention on Mobility-on-Demand which encompasses...
Models of recursive preferences are commonly associated with a preference for early resolution of uncertainty, often regarded as an important economic channel in applications. This dissertation provides a different understanding of recursive preferences based on attitudes toward correlation, and in particular aversion to intertemporally correlated risks. Part 1 provides a...
Even though a number of techniques have been developed for motion generation and perception, few of them focus on the computational efficiency and theoretical guarantees at the same time. Typically, improved guarantees come with increased complexity, making theoretically guaranteed methods challenging use in real-time applications. Thus, existing methods usually have...
Thermoelectric devices utilize semiconducting n-type and p-type thermoelectric materials to convert heat into electricity. Despite their promise for deep space power generation or waste heat recovery, most high-performing thermoelectric materials reported in literature are absent in practical applications - partially due to inconsistent synthesis and poor mechanical performance. This work...
All animals purposefully navigate feature-rich environments: while exploring, in search of vital resources of food and water, finding mates, and patrolling and marking habitats. During these complex behaviors, continuous analogue input information from peripheral sensory organs guides discrete and digital sequential motor output; accordingly, each action is informed, modulated, or...
In this dissertation, I assert that a contradictory aesthetic has remained and been reborn in the U.S. daytime soap opera through time and technology; I call this the “everyday implausible.” Using textual analysis and archival research, I follow this genre from its beginnings on radio, through its move to television...
Asymmetric relationships between creators and consumers in peer-produced knowledge repositories produce inequitable knowledge representation--or knowledge gaps. These gaps result in unequal access to information, and downstream technologies that leverage peer-produced data perpetuate these inequities. Effective knowledge gap identification represents a necessary first step towards equitable knowledge representation. However, while prior...
Eukaryotic genomes are organized into chromatin, which acts to regulate access to the organism’s genetic material. A large and diverse class of proteins, known as chromatin modifiers and remodelers, are responsible for regulating the composition and structure of chromatin by monitoring nucleosomes. Chromatin remodelers are involved in multiple cellular processes,...
Urban Air Taxi (UAT) is the use case of passenger-carrying Urban Air Mobility (UAM) at its mature state, and it offers a ubiquitous on-demand (or nearly on-demand) per-seat service that moves passengers in urban or suburban areas using groundbreaking aircraft. However, the absence of a dominant electric vertical take-off and...
The first chapter of this dissertation looks at strategic complementarities among investors inpooled investment vehicles where fund managers and investors have different objectives. Could
lessening strategic complementarities among the investors of a fund make investing in the fund
less appealing? Exploiting the 2014 Reform of the money market mutual fund...
Dendritic microstructures form during the solidification of a variety of metal parts, from traditionally cast engine blocks to 3D-printed specialty tooling. These dendrites can evolve through growth, coarsening, fragmentation, and the formation of a Columnar-to-Equiaxed Transition (CET), which all can greatly affect material properties. However, the basic science behind these...
Market growth is an important goal for consumer businesses, often leading to lower marginal cost, higher operational efficiency, and larger assortment size - all of which help achieve dominance over competition. Yet, retailers and manufacturers alike should carefully manage their supply chains to sustain growth in customer base and extract...
Scalable processing of well-defined interfaces is key not only for wider application of two-dimensional (2D) materials in technology but also for improved fundamental understanding. Atomic layer deposition has useful characteristics, especially self-limited growth at low temperatures, that make it well suited for the production of uniform interfaces. Related processes, such...
Over 10 billion tons of concrete are produced for the construction industry every year, making concrete the second most used substance on Earth, only surpassed by water. With such high importance as a building material, there is significant need for the ability to accurately model concrete behavior. As a quasi-brittle...
Sensorimotor integration is a general term to describe how task-specific motor output is generated from the selective and rapid processing of sensory and motor information. The rodent vibrissal (whisker) system is an important model for the study of sensorimotor integration and active tactile sensing. This research uses the rodent vibrissal...
RAS is one of the most frequently mutated oncogenes in cancer with ~30% of all human tumors harboring a mutation in either HRAS, NRAS, or KRAS isoforms. Despite countless efforts for the development of small molecule inhibitors for RAS, it remains an elusive target in the clinic. Here I demonstrate...
With the rapid growth of demand for data center services, the energy and water use of data centers has become a critical concern in the contexts of energy use, climate change, and freshwater conservation. Therefore, understanding, quantifying, and optimizing the use of energy and water resources in data centers has...
The rise and racial gap in maternal mortality and morbidity in the US growing public health crisis. The US maternal mortality rate is double that of peer countries such as the UK and Canada. Even more striking, Black women are 243% more likely to die from childbirth-related causes. According to...
Wearable-based human activity recognition is well-studied in the machine learning and pervasive computing community. A large corpus of studies focused on using wearable sensors to recognize health-related behaviors that involve high periodicity in the sensed signal, such as sitting, walking, and running. Other activities that occur less frequently throughout the...
Automated driving has become a very popular topic in the recent years and is becoming more and more of a reality. In this new trend, High Definition (HD) maps play an important role in many ways that will provide a safer and more efficient driving experience, especially in terms of...
Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus in these anatomical compartments and how and when the virus reaches those sites. To...
Modern data sets are increasingly vast, not only in the number of samples, but also in the number of measurements, or features, that they contain. This high-dimensionality poses a unique set of problems for data analysis due to a set of phenomena known as ``the curse of dimensionality.'' This thesis...
We consider general utility models and information structures of the agents and illustrate when economic conclusions for designing simple mechanisms in classical settings extends for general environments. We show that whether economic conclusions can be generalized depends on the details of the generalizations. For example, in single-item auction, competition and...
In the wake of environmental catastrophe, active intervention is needed to heal trauma, resist erasure, and navigate changing communities. Focusing on New Orleans after the federal levee failures following Hurricane Katrina, this dissertation looks across a diverse mix of case studies to theorize how communities utilize performance to navigate mass...
Prostate cancer is the most common cause of cancer among men in the United States, and the second most common cause of cancer-related death, accounting for significant morbidity and mortality. This dissertation describes the genomic landscape of prostate cancer from multiple angles to identify mechanisms of disease heterogeneity amongst patients....
Bioelectronic devices at the biotic/abiotic interface face a number of key challenges that include device degradation when exposed to biological fluid, their elicited immune response due to mechanical mismatch, and poor signal transduction. Organic electronic materials and their devices, such as organic electrochemical transistors (OECTs) address these shortcomings. They can...
This dissertation explores the experience of violence and precarity among Central American youth as they travel through Mexico to the United States. Based on a multi-sited ethnographic study conducted across Mexico from 2015 to 2019, I illustrate how the journey of these youth migrants is, in its basic expression, an...
Does race matter globally, beyond national and regional contexts? If yes, then how exactly? I argue that race matters globally and develop an account for understanding that significance. I call the account “global racial capitalism.” In chapter 1, I offer background to motivate and defend the thesis that race matters...
Numerous insights into the sensorimotor systems that guide the control of voice have been garnered by observing how the system responds to manipulations of its auditory feedback. However, current approaches may be limited in the exploration of more complex parameters of volitional and adaptive voice control due to their limited...
Triplet excited state chemistry has enabled a range of important organic transformations by accessing reaction pathways inaccessible to photoredox chemistry. Such photoreactions are triggered by triplet photosensitizers, which absorb visible-light photons and transfer the energy to the substrate or to a co-catalyst through triplet-triplet energy transfer (TT EnT). The most...
The airway epithelial cells (AECs) lining the conducting passageways of the lung secrete a variety of immunomodulatory factors. One interesting pair of molecules produces by AECs is IL-6 and prostaglandin E2 (PGE2). PGE2 limits lung inflammation and promotes bronchodilation. By contrast, IL-6 drives intense airway inflammation, remodeling, and fibrosis. The...
Enzyme substrate promiscuity has significant implications for metabolic engineering. The ability to predict the space of possible enzymatic side reactions is crucial for elucidating underground metabolic networks in microorganisms, as well as harnessing novel biosynthetic capabilities of enzymes to produce desired chemicals. Reaction rule-based cheminformatics platforms have been implemented to...
Mixing by cutting-and-shuffling (like that for a deck of cards or a Rubik's cube) is a paradigm that has not been studied in detail even though it can be applied in a variety of situations including the mixing of granular materials. Mathematically, cutting- and-shuffling is described by piecewise isometries (PWIs),...
With the ever-increasing demand for more complex functionalities and miniaturization of photonic devices, the design of such devices requires a whole new different approach, deviating from classical photonic design approaches. Conventionally, the design of a typical photonic device starts with a prior knowledge, intuition, and practical experience of specific behavior...