Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins, desmogleins and desmocollins, are related to the classical cadherins but their cytoplasmic domains are tailored for anchoring intermediate filaments instead of actin to sites of cell-cell adhesion. The...
Total synthesis of natural products provides an avenue for investigation of complex chemical scaffolds, not only delivering access to biologically impactful molecules but also lending a deeper understanding of their inherent chemical reactivity. Expansion of reaction methodology, optimization of biological activity, and absolute structural confirmation can all be accomplished via...
CD99-Like 2 (CD99L2) is a 52 kDa type I glycoprotein expressed on leukocytes and endothelial cells as well as other cell types in mice. It is related to CD99, although it shows only 32% sequence identity. CD99L2 has been shown to play a role in leukocyte extravasation in mice under...
Nuclear magnetic resonance (NMR) measurements have been performed on the heavily Cu-doped ($x = 0.13$, 0.18, 0.24, 0.39, 0.48), and underdoped (x = 0.01 and 0.012) \NaFeCuAs~ single crystals, to reveal the nature of the magnetism, and to investigate how the electronic and magnetic properties of the system evolves with...
The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal domain that permits mitochondrial binding, but its physiologic significance remains unclear. We generated mice lacking the HK1 mitochondrial-binding...
Background: Glioblastoma (GBM) tumors are the most malignant brain cancers and are characterized as Grade IV astrocytomas by the World Health Organization. GBM tumors can be classified into three molecular subtypes known as proneural, classical, and mesenchymal. In addition, GBM tumors also have a small population of cells known as...
Desmosomes, complex structures found at intercellular junctions, are important for the development, structural integrity, and immune barrier of the skin. Extracellular components of the desmosome connect neighboring cells and intracellular interactions amongst cadherin, armadillo, and plakin proteins anchor the desmosome to intermediate filaments. Beyond their canonical role as “spot welds”...
This collection includes all of the supplemental figures that were not included in the thesis document. (Isotopic, Mycorrhizal Morphology and Temperature)
The in-depth inspection by WIDOT detected two sites that had visible cracks in the stiffener-to-hanger diaphragm welds, the east side of Hanger 6 in the north tie girder, and the east side of Hanger 4 in the south tie girder. Additionally, many ultrasonic indications were detected by WIDOT in the...
Northwestern University developed copper-precipitation-hardened, high-performance weathering steel (NUCu 70W Steel) that is produced by hot rolling after casting and then air-cooling. Due to simple processing the steel is fabricated at lower cost than competing high-performance steels that require quench and tempering. NUCu 70W steel can be easily welded without pre-...