Understanding the chemical complexity of the extracellular matrix (ECM) and how chemical, biological, and physical cues bring changes to the behavior of cells has remained a grand challenge. Addressing these questions requires not only achieving systematic control over the interactions between cells and the ECM but also utilizing suitable analytical...
This dissertation demonstrates how related initiatives to reform narcotics laws and protect consumers from dangerous medicines – taking hold in the 1950s and institutionalized in the mid-1960s – created the foundation for a massive expansion of federal policing of illicit drugs. Centered on the history of the Food and Drug...
Genetic studies have found variants in the protein-degrading autophagy-lysosomal pathway (ALP) to be among the most common risk factors for developing Parkinson’s disease (PD). Macroautophagy (MA) is the arm of this pathway which delivers cytosolic components to lysosomes for degradation and is essential for neuronal health. The defining pathological protein...
My submission is a data dashboard that depicts global trends for new and total COVID-19 cases between Jan 01, 2020 and March 08, 2021. It contains two tabs (new and total cases) with three interactive visualizations. Two maps, an original and a log-scale-filled, show the number of new COVID-19 cases...
The interior point (IP) method for nonlinear programming was pioneered by Anthony V. Fiacco and Garth P. McCormick in the
early 1960s. The basis of IP method restricts the constraints into the objective function (duality
( http://en.wikipedia.org/wiki/Duality_%28optimization%29) ) by creating a barrier function. This limits potential solutions to
iterate in only...
The authors of the article “Toward Environmentally Sustainable Digital Preservation” created this workshop as a space for participants to discuss issues of environmental sustainability in digital preservation, identify and enact change toward sustainable practices in their organizational contexts, and identify and plan further research. The workshop was run for the...
Harbor seal whiskers exhibit a tapering elliptical geometry uniquely suited to detect wakes (trails of water produced by upstream bodies) in ways a regular, tapering, or elliptical cylinder cannot. Previous studies into the matter have relied on idealized representations of the geometry the whiskers seem to take on and have...
The decision to breastfeed or formula feed is a largely contested one by mothers, healthcare administrators, and politicians. Yet, research suggests that both breastfeeding and formula feeding are healthy ways to provide nourishment to newborn babies. Considering this, I sought to analyze why this decision is such a site of...
Introduction
To assess disparities in retesting for glycated hemoglobin (HbA1c) and systolic blood pressure (SBP) among people with diabetes mellitus (DM) and hypertension (HTN), respectively, we analyzed medical records from a lesbian, gay, bisexual, transgender, queer-specialized federally qualified health center with multiple sites in Chicago.
Research design and methods
We...
