Genetic studies have found variants in the protein-degrading autophagy-lysosomal pathway (ALP) to be among the most common risk factors for developing Parkinson’s disease (PD). Macroautophagy (MA) is the arm of this pathway which delivers cytosolic components to lysosomes for degradation and is essential for neuronal health. The defining pathological protein...
Harbor seal whiskers exhibit a tapering elliptical geometry uniquely suited to detect wakes (trails of water produced by upstream bodies) in ways a regular, tapering, or elliptical cylinder cannot. Previous studies into the matter have relied on idealized representations of the geometry the whiskers seem to take on and have...
The interior point (IP) method for nonlinear programming was pioneered by Anthony V. Fiacco and Garth P. McCormick in the
early 1960s. The basis of IP method restricts the constraints into the objective function (duality
( http://en.wikipedia.org/wiki/Duality_%28optimization%29) ) by creating a barrier function. This limits potential solutions to
iterate in only...
The textbook proceeds with an introduction to theory and concept building, moves to an explanation of causal inference (how do we 'know' whether something is causal?), and then provides a quick introduction to data and hypothesis testing. Following that, each chapter is devoted to a particular research method used within...
The authors of the article “Toward Environmentally Sustainable Digital Preservation” created this workshop as a space for participants to discuss issues of environmental sustainability in digital preservation, identify and enact change toward sustainable practices in their organizational contexts, and identify and plan further research. The workshop was run for the...
Understanding how spin waves propagate through ferromagnets is an important component of a wider international effort to create spintronic devices. In this thesis, we develop a propagating spin wave spectroscopy to make a variety of measurements on thin films of Yttrium Iron Garnet (YIG), a material known for having long...
The decision to breastfeed or formula feed is a largely contested one by mothers, healthcare administrators, and politicians. Yet, research suggests that both breastfeeding and formula feeding are healthy ways to provide nourishment to newborn babies. Considering this, I sought to analyze why this decision is such a site of...
Introduction
To assess disparities in retesting for glycated hemoglobin (HbA1c) and systolic blood pressure (SBP) among people with diabetes mellitus (DM) and hypertension (HTN), respectively, we analyzed medical records from a lesbian, gay, bisexual, transgender, queer-specialized federally qualified health center with multiple sites in Chicago.
Research design and methods
We...