Synthesis of Solvent Reorganization Energy ProbesPublic Deposited
In many biological systems, ligand-receptor pairs bind to each other via noncovalent interactions such as hydrogen-bonding and Van der Waals forces. This project’s method of studying these interactions uses electron transfer theory. When a receptor binds to a redox-modified ligand, there is a change in the reorganization energy of the redox center and a concurrent change in the rate of electron transfer. With the aim of developing a model system to test in future electrochemical studies, an alkane thiol was synthesized that incorporates a ligand, desthiobiotin, and a pyridine for redox modification. The synthesis revealed that the final product is present in two conformations.