Quantifying Hemodynamic Compromise and Stroke Risk using Magnetic Resonance ImagingPublic Deposited
Stroke is the leading cause of death and long term disability in the industrialized world. With the current population aging, the number of individuals at risk of stroke along with the associated health care costs are anticipated to rise considerably in the coming years. Consequently, there is an unmet need to identify high risk patients so that prophylactic medical management may prevent this devastating event. In this work, we discuss several magnetic resonance imaging (MRI) protocols that model underlying cerebral hemodynamic processes involved in stroke. Specifically, with regards to ischemic stroke, we present a novel imaging method to measure oxygen extraction fraction (OEF) and show that it correlates with hemodynamic compromise in patients with intracranial atherosclerotic disease. Furthermore, we validate an MR technique for quantifying cerebrovascular reserve (CVR) in an animal model, and show it correlates with the stage of hemodynamic compromise. Lastly, we examine hemorrhagic stroke and propose a new imaging metric associated with aneurysm rupture risk and wall thickness.