Replication Data for: Repressive gene regulation synchronizes development with cellular metabolismPublic Deposited
Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that weak repressors of gene expression provide the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that is able to capture this feature of GRNs, we show that developmental errors that occur when a repressor is lost are greatly diminished in frequency if cellular metabolism is slowed. This dataset includes all of the simulations described in our study.