Organic Monolayer Modification on a Silicon Surface Using Sonagashira Coupling: Working Towards the Development of Biological Sensors,

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This research illustrates the modification of an iodostyrene layer on a Si(111) surface using a Sonogashira reaction. This was accomplished by applying UV irradiation (254 nm) to a hydrogen-passivated silicon surface in a solution of iodostyrene in benzene, followed by a Sonogashira coupling between the iodine group from iodostyrene and 4-bromophenylacetylene in a microwave condition at 40° C. Two precursor molecules — iodostyrene and 4-bromophenylacetylene — were successfully synthesized and characterized by nuclear magnetic resonance (NMR) spectroscopy and gas chromatographymass spectrometry (GC-MS). X-ray photoelectron spectroscopy (XPS) was used to characterize both the iodostyrenelayered surface and the surface that was subjected to Sonogashira coupling. In addition, a Sonogashira coupling of these two molecules in solution via microwave was carried out prior to the solid phase reaction to ensure selective formation of product. The ability to modify the organic layers on a Si(111) wafer is a promising step toward developing reactive surfaces that can be used as scaffolds for more complex molecules and eventually as biological sensors

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  • 07/19/2018
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