The structure of the North American crust and mantle was investigated using P wave teleseismic tomography and the links between seismic tomographic models, locations of volcanism, sediment isopachs, and continental scale crustal structures via plate reconstruction modeling. Nearly 50,000 teleseismic P wave delay times were measured from seismograms recorded by...
Infidel(itie)s of Colour: Unruly Black Bodies, Modernity and Performance in Post-Apartheid South Africa focusses on the ways that queer and feminist artists of colour draw upon their traditional black cultural heritage and spiritual practises as a means of laying claim to cultural citizenship and belonging in post-apartheid South Africa. I...
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated Cas proteins provide an immune-like response in many prokaryotes against extraneous nucleic acids. CRISPR-Cas systems are classified into different classes and types that vary widely in composition, target recognition, and overall mechanism. The main division of CRISPR-Cas systems occurs between...
The focus of this thesis is on evaluating, designing, and applying statistical methods that elucidate molecular mechanisms by seeking to understand the pathways that contribute to disease. Chapter 1 introduces the field and motivates the work in this thesis. Chapters 2, 3, and 4 describe original work. Chapter 5 recapitulates...
The halide perovskites AMX3 (A = large cation, B = Sn or Pb, and X = halide) have been the subject of intense investigation due to their outstanding optical and electronic properties, which have enabled high solar cell efficiencies thanks to a beneficial electronic structure and long charge carrier lifetimes....
Motor planning is fundamental to the performance of everyday reaching movements. The influence of planning is not limited to voluntary movements but extends to involuntary movements initiated in response to sensory stimuli, such as postural perturbations applied to the arm. Stroke alters voluntary reaching and the involuntary response to perturbations,...
This dissertation concerns the probabilistic aspects of diffusion processes generated by a family of differential operators, which is similar to the family of hypoelliptic Laplacian operators, acting on the tangent bundle of a compact Riemannian manifold. By lifting the processes to the product of the frame bundle and the euclidean...
Despite improvements to diagnostics and treatment methods, colorectal cancer remains the second leading cause of cancer death in the United States. Colonoscopies, the gold standard for colorectal cancer screening, can significantly increase the patient’s chance of survival through early detection. However, colonoscopy cost, surgical complications, and patient bowel preparations limit...
This dissertation is a wide-ranging study on real estate and the effect of financial constraints on economic activity. In the first chapter, I use granular data on home builder housing developments to provide new evidence that firms spread negative revenue shocks across projects via their internal capital markets. I analyze...
This dissertation explores the interrelationship between time, labor, and literature during the rise of British industrial capitalism. By tracing a tradition of social criticism from Percy Shelley to William Morris that runs through the Chartist movement, Thomas Carlyle, and Charles Dickens, it isolates and explicates a distinctive existential mood, or...
The physical boundary layer, or interface, between two different phases of matter is the site of chemical and physical processes that are critical to many research fields. Many of these interfaces contain electric charge, which influences the structure and composition of the interfacial region and the interactions between the interface...
Supported vanadium oxide materials have been extensively studied for alkane oxidative dehydrogenation (ODH) reactions due to their high activity and selectivity. The catalytic activity of supported VOx materials is influenced by the surface coverage of VOx sites and hence the distribution of V=O, V-O-V, and V-O-S (S, support) bonds. The...
The role of nuclei nanoenvironment in cellular function has been a challenging problem in biology due to the lack of chromatin 3-dimension (3D) structure imaging/capturing techniques and theory connecting physical structure of chromatin to transcription. Recent studies on optical properties measurement on biological sample techniques, nanoscale imaging techniques and chromatin...
Gene regulatory networks (GRNs) are important abstractions of the complex regulatory interplays between genes, proteins, metabolites, and other molecular-level entities. Comprehensive GRNs provide high-level overviews of the topology of gene-gene interactions and their purposes, thereby enabling a comprehensive understanding of their role in phenotypic variation, disease mechanisms, and other biological...
This dissertation examines the language of force in Robert Musil’s Der Mann ohne Eigenschaften (MoE) as a site of literary self-reflection. It investigates how the text employs a constellation of “force” terms – including not only the words Kraft, Energie, and Leistung, but also images of physical and chemical forces...
In this thesis we present methods for estimating network metrics via random walk sampling. More specifically, we generalize the Hansen-Hurwitz estimator and the Horvitz-Thompson estimator to estimate the shortest path length distribution (SPLD), closeness centrality ranking, and clustering coefficients of a network. Those are important metrics to a network, but...
Circuit-level Dynamic Timing Slack (DTS) has emerged as a compelling opportunity for eliminating inefficiency in modern low-power systems. This slack arises when all the signals have propagated through logic paths well in advance of the clock signal. When it is properly identified, the system can exploit this unused cycle time...
This dissertation is about three of Cicero’s notable projects in ideal theory in his middle and late periods (between roughly 54-43 BCE). It comes during a resurgence in interest in Cicero’s contributions as a philosopher. First, I discuss Cicero’s philosophical account of vera gloria (true glory) in contradistinction to mere...
This dissertation proposes an oracle efficient estimator in the context of a sparse linear model. Chapter 1 introduces the penalty and the estimator that optimizes a penalized least squares objective. Unlike existing methods, the penalty is differentiable – once, and hence the estimator does not engage in model selection. This...
Rationally assembled nanostructures exhibit distinct physical and chemical properties beyond their individual units. The development of nanofabrication tools enables precise structural defining of nanomaterials scalable to large areas. This dissertation focuses on plasmonic nanoparticle arrays that show unique diffractive coupling with lattice spacings engineered close to the wavelength of light....