In the past few decades, psycholinguistic and neurolinguistic research has shown that nouns and verbs are processed differently in cognitively healthy individuals, and can be selectively impaired in aphasic individuals. However, this noun-verb dichotomy is poorly understood. This dissertation investigated cognitive and neural distinctions between nouns and verbs by studying...
How do households confront insecurity? This dissertation is a study of how households navigate insecurity as observed through struggles with homeownership and foreclosure. I discuss insecurity as a multi-dimensional experience that puts important resources at risk of loss and reaches into many areas of family life, including health, wealth, food,...
When we speak, we communicate not only with the words we choose, but also with the patterns of sound we create. As auditory experts, musicians are especially adept at making sense of sound, and accumulating research reveals that this extends to their processing of speech and other communication signals. Much...
I present research in systems of biomedical relevance consisting of agents near or com- prising surfaces using computational approaches. The research topics include formation of bacterial biofilms, behavior of charged species near stacked, like-charged lamellae, and the the conformational behavior of lamellae with strong self-attraction.
In chapter 2, I present...
This dissertation presents some development of the single molecular ion precision spectroscopy experiment including construction of the project, spectroscopy state readout, and production of ultracold molecules. Such molecular ion spectroscopy aims at testing fundamental physics such as probing the time variation of electron-proton mass ratio.
The theories and characterization of...
The properties of crystalline materials are controlled by their composition and by their structure, however, the structure of a crystal is only partly controlled by its composition. Development of specifically directed inorganic syntheses will require an understanding of the dynamics of crystal phase forming processes, especially those processes involved in...
Lattice models of fermions, bosons, and spins have long served to elucidate the essential physics of quantum phase transitions in a variety of systems. Generalizing such models to incorporate driving and dissipation has opened new vistas to investigate nonequilibrium phenomena and dissipative phase transitions in interacting many-body systems. Circuit- QED...
We argue that a country’s level of wealth inequality can be viewed as a reflection of the quality of its housing rental market. Using the ECB’s Household Finance and Consump- tion Survey (HFCS), we document that the aggregate homeownership rate and various measures of wealth inequality are negatively correlated across...
Mixing of granular materials is an important engineering process, and a very complex problem. In this thesis, I use granular mixing in a half-full biaxial spherical tumbler (BST), a spherical container that rotates sequentially about two orthogonal axes, to motivate the study of mixing with piecewise isometries (PWIs), a rich...
Amorphous In-Ga-Zn-O (a-IGZO) and other amorphous oxide semiconductors are attracting increasing attention from the display industry for their high electron mobility, ease of large-area manufacture, and potential for future flexible electronics. However, such amorphous materials often show instability under gate voltage bias, temperature, and illumination stress, with extremely slow relaxation...
The behavior of ions in liquids confined between macromolecules determines the outcome of many nanoscale assembly processes in synthetic and biological materials such as colloidal dispersions, emulsions, hydrogels, DNA, cell membranes, and proteins. Theoretically, the macromolecule-liquid boundary is often modeled as a dielectric interface and an important quantity of interest...
Tribological behaviors of lubricated interfaces are strongly affected by the interactions between mating surfaces and the rheological properties of the lubricant between them. This research aims to improve lubrication through two approaches: 1) designing surface textures for lubrication enhancement and adhesion reduction, and 2) developing lubricants of desired rheology.
Molecular...
Broadband networks are one of the most economically significant and fastest growing sectors of the Internet. Recent studies have shown that providing broadband Internet access is instrumental for social and economic development. Several governments, as well as the UN, have gone so far as to label broadband access a basic...
Even though renal blood flow accounts for nearly a quarter of cardiac output, the renal medulla operates in an environment with a scant supply of oxygen. The reason for this apparent discrepancy is thought to be threefold. Blood flow to the outer medulla is less than 50% of that received...
Glaucoma is a neurodegenerative blinding disease associated with increased intraocular pressure, which is caused by an increased resistance to the outflow of aqueous humor. Although the cause for increased resistance remains unknown, it has been associated with a decreased density of pores in the cells of the inner wall endothelium...
This dissertation develops and applies coupled marine sulfur and strontium cycle modeling to the highly dynamic Early Cretaceous demonstrating the value of increased model constraint from linkage of biogeochemical cycles with shared forcing factors. A foundation for this work is first provided by review of relevant geochemical, sedimentological, and paleontological...
Chronic pain is a prevalent and under-treated condition that remains a mystery to the medical system and a major social and economic problem. Unfortunately, there is no single treatment superior to others for relieving chronic pain. While recent scientific discoveries have provided us with functional and anatomical brain biomarkers of...
The FDA approvals of afatinib and ibrutinib in 2013 led to a heightened interest in cysteine-reactive covalent inhibitors. However, there are few methods to discover new cysteine-reactive inhibitors for enzymes for which reversible binding scaffolds are not known. To this end, we rationally designed a chemical system to attach a...
The striatum is a subcortical nucleus that regulates a number of complex activities ranging from voluntary action selection to the subconscious formation of habit. The coordination of these operations is mediated by the principle cells of the striatum, spiny projection neurons (SPNs). SPN activity is dictated by a confluence of...
E2F-2 is a Retinoblastoma (Rb)-regulated transcription factor induced during terminal erythroid maturation. Cyclin E-mediated Rb hyper-phosphorylation induces E2F transcriptional activator functions. E2F-2-loss causes reduced peripheral red blood cell (RBC) counts, without altering relative abundances of erythroblast subpopulations. To determine how E2F-2 regulates RBC production, we comprehensively studied erythropoiesis using knockout...
Spherical Nucleic Acids (SNAs) are nanoparticle bioconjugates that have found use in a wide-range of diagnostic and therapeutic applications. These nanomaterials are composed from inorganic or organic core nanoparticle scaffolds that are functionalized with a dense surface layer of nucleic acids (typically DNA or RNA) that are oriented in a...
Metalloporphyrins fulfill incredibly diverse chemical roles in biology and photocatalysis, where they act as photosensitizers, redox sites, substrate binding sites, and facilitators of long range electron transfer. Metalloporphyrin chemistry is uniquely tuneable through conformation and functionalization of the porphyrin ring, choice of metal, and interaction with the environment as these...
Gene expression is tightly regulated at the level of transcription through cooperation between cis-regulatory elements and trans-factors that bind to the regulatory elements. Together, these factors regulate the higher order chromatin structure which establishes domains that organize the genome and coordinate gene expression. However, the molecular mechanisms controlling transcription of...
The Introduction and Appendix i-A outline briefly the history of Titan exploration since its discovery by Christiaan Huygens in 1675 through the recent International Mission of Cassini- Huygens. It discusses the roles of some of the ten most abundant elements in the Universe (H, He, C, N, O, Ne, Mg,...
Worldwide, governments are beginning to take action to reduce anthropogenic CO2 emissions in order to mitigate the extent of global climate change. The largest fraction of global CO2 emission comes from electrical power generation, which is rapidly being converted to wind and solar installations. The intermittent nature of renewable resources...
In this dissertation, we present three empirical studies investigating the role of linguistic experience in the processing of probabilistic information during speech production, speech perception, and across modalities. In all studies, we focus on a particular type of probabilistic information related to the probability of a word in a discourse...
Science at the nanoscale poses several recurring difficulties. How can we control the assembly of objects too small for direct manipulation to be practical? How can we extend that control to extit{in vivo} systems so we can make use of nanotechnology in medicine? And how can we recreate the extraordinary...
By 2020, there will be more than 200 billion sensor enabled objects world-wide in the Internet of Things (IoT). The biggest challenge of future IoT is to provide ultra scalable wireless access for a massive number of devices. The goal of this thesis is to build up a model for...
Patients with the Primary Progressive Aphasia (PPA) clinical syndrome have diverse forms of neuropathology, one of which is the cellular and molecular abnormalities of Alzheimer’s disease (AD), at post mortem autopsy. Structural anatomical differences might aid in ante mortem differential diagnosis of neuropathology. The studies in this dissertation investigated one...
Despite major advances in the past half-century, significant issues such as educational inequality persist in American education. Accountability policy has become a central, resilient approach for addressing such issues. We see this in the ongoing enactment of the 2001 No Child Left Behind Act (NCLB) and the recent adoption of...
Organic photovoltaic (OPV) solar cells aim to provide efficient, flexible and lightweight photovoltaics (PV) with simple processing and low-cost. Advances in device optimization, structural and molecular design, as well as mechanistic understanding have helped increase device efficiency and performance. Within the framework of active layer optimization, systematically improving bulk heterojunction...
Planets and planetary systems change in brightness as a function of time. These "light curves" can have several features, including transits where a planet blocks some starlight, eclipses where a star obscures a planet's flux, and rotational variations where a planet reflects light differently as it spins. One can measure...
Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for characterizing molecular systems. It combines the chemical selectivity of vibrational spectroscopy with plasmonic signal enhancement to achieve the ultimate limit of detection--a single molecule. By overcoming the effects of ensemble averaging, single molecule SERS (SMSERS) probes distributions in molecular interactions and...
In 2012 the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) collected 19.7 fb-1of data at a center of mass energy of 8 TeV. This thesis presents two analyses focusing on the Z boson. The first is a search for the never before seen decay of a...
Consider the role of waiting rooms as informal learning environments. In this thesis, I examine a pediatric hematology and oncology clinic to evaluate the patient learning experience. Through staff interviews, waiting room observations, and a review of educational materials I argue that this process is in need of redirection. Most...
This project examines the uneven adoption of therapeutic initiatives within the organizational field of American museums to ask: How do people frame museum-going as “good” for visitors’ health? Existing research on legitimation processes would predict cultural institutions respond similarly to pressures for greater accountability from their external environments, or resist...
How mental representations are constructed and how they evolve are central problems for cognitive science. Representation decisions help determine what computations are hard or easy. Structured, relational representations are a hallmark of human cognition. Developmental studies show that children do not perform as well as adults in tasks that require...
Substance use and substance use disorder (SUD) may be variables that influence the course of HIV/AIDS risk behaviors as youth age. To our knowledge, no prospective longitudinal study has examined the association between categories of substance use disorders including alcohol use disorder alone, marijuana use disorder alone, comorbid drug use...
CD1 molecules represent a class of antigen presenting molecules that present lipid antigens to cognate T cells. These molecules have been identified in all mammals examined so far. Unlike MHC molecules, which are highly polymorphic, CD1 molecules exhibit limited polymorphism and are divided in to two groups – 1 and...
A disconnect exists between the behavior of transcriptional and genetic regulation in bacterial systems when comparing phenotypic patterns and dynamics of a population to those observed at the single cell level. In this thesis, we developed a number of tools and assays to better understand, overcome, and predict the challenges...
While infrequent, clay slope failures caused by earthquakes result in loss of life and substantial property damage. In strong seismicity areas, it is sometimes assumed that the stability of clay deposits can be evaluated through the residual undrained strength that is applicable at large deformations. A crucial factor missing in...
The airway epithelium forms an active barrier between the internal and external environments and has multiple roles critical to normal function of the lung. Its development and function are controlled by a network of transcription factors that regulate gene expression in response to varying stimuli. Dysfunction of this tissue plays...
Short-wave infrared (SWIR) photon detection has become an essential technology in the modern world. Sensitive SWIR detectors with low noise levels, and high signal-to-noise-ratios are highly desirable for a variety of applications including light detection and ranging, optical tomography, and astronomical imaging. As such many efforts in infrared detector research...
The ability to track labeled cancer cells in vivo would allow researchers to study their distribution, growth and metastatic potential within the intact organism. Magnetic Resonance (MR) imaging is invaluable for tracking cancer cells in vivo as it benefits from high spatial resolution and absence of ionizing radiation. However, many...
The circadian clock is a biological oscillator present in all terrestrial life forms that aligns organismal functions with the daily rising and setting of the sun. In mammals clocks are expressed both in pacemaker cells in the brain that are directly entrained by light as well as in all peripheral...
This dissertation draws on a field-level, qualitative study of business analytics to explore the legitimation and design of knowledge practices. In the last few decades, both the power and the acceptance of business analytics have advanced dramatically; nonetheless, end-users and clients can still be deeply sceptical of particular analytics practices...
Fungi have an immense untapped store of natural products, small molecules that can often be repurposed as pharmaceuticals. The genes that encode secondary metabolic machinery are often genomically co-localized into biosynthetic gene clusters. Because of the immense energetic costs that goes into producing the biosynthetic pathway and its products, strict...
The progressive women’s movement in the United States during the mid-twentieth century enjoyed increased support and success until national politics were dominated by conservatives during the 1980s. This dissertation analyzes the discourse around women’s issues created by two of the largest conservative women’s organizations, Eagle Forum and Concerned Women for...
Growing energy and climate concerns in the United States and across the world demand improvements in energy efficiency, conservation, and renewability. Solid oxide fuel cells (SOFCs) are highly efficient devices that electrochemically convert the chemical energy of a fuel to electricity. These devices can operate on natural gas as a...