This dissertation investigates a single-column model for Arctic energy balance in the limit as a smoothing parameter associated with ice-albedo feedback tends to zero. This limit is a common modeling approximation used in conceptual climate models, and we explore the implications of taking this limit on bifurcations associated with the...
Spinal cord injury occurs with a worldwide incidence of 13-33 cases per million per year, and more than 2.5 million patients worldwide suffer from spinal cord injury (SCI)-related disability (1, 2). Different methods have been attempted to promote axonal regeneration, including neurotrophin injection, hydrogel injection, olfactory ensheathing cells implantation and...
Porous metal structures exhibit numerous advantages over dense materials due to their high specific stiffness, strength, damping, energy absorption, and surface areas, making them suitable for applications ranging from actuators to medical implants. However, traditional foam manufacturing methods do not provide sufficient control of the foam micro-architectures, and the creation...
Gels are three-dimensional polymer networks capable of absorbing a large amount of solvent molecules subject to various external stimuli (pH, temperature, light, etc.). They exhibit a rich mechanical behavior and prominent nonlinearity owing to their high flexibility, stimuli-responsiveness and superabsorbency. More compelling are the intriguing morphologies and novel functionalities achieved...
The aim of this dissertation is to make sense of nearly a century and a half's worth of observations concerning skin based electroadhesion phenomena. While this is a noble goal in and of itself, further motivation of this work is drawn from fact that the electroadhesive effect is increasingly being...
The unprecedented crimes of World War Two, especially those committed by the Nazi state, unleashed an equally unprecedented effort to hold perpetrators accountable and secure justice for millions of victims. This effort encompassed hundreds of trials of thousands of individuals in the immediate postwar period and continues to the present...
Metabolic engineering of microorganisms to produce useful compounds from renewable substrates is a promising means for sustainable, on-demand production of chemicals. However, efforts to design and engineer microbial cell factories are constrained by costly and slow “build” times in which each genetic variation requires re-engineering a new strain for each...
The limits of miniaturization of electronic device components and the steady need for faster computation power have motivated the discovery and cultivation of low-dimensional materials. Among these, two-dimensional (2D) materials have exhibited a wide range of superlative optoelectronic, thermal and mechanical properties. The interest in 2D materials took-off with the...
Mechanisms for sensing fluid flow are well studied in arthropods and in some aquatic mammals, but we know very little about how terrestrial mammals detect and localize airflow (Chapter 1). In this thesis, I will describe a series of studies in rodents that investigate the behavioral, mechanical, and neural basis...
Literary critics typically oppose chronological and anachronistic historiographical schemes. In paired readings of early modern and contemporary poets, my dissertation, “The Shock of the Old: Periodization, Poetics, and Diachronic Exchange between the Renaissance and the Avant-Garde” investigates a series of poetic texts that defy this opposition. The poetic objects I...
The rodent whisker system is a widely used model to study the sense of touch. Its neuroanatomy parallels that of the human, but its mechanics are vastly simplified compared to that of the human tactile system. Just like other modalities with complex sensor accessory structures, the geometry, mechanics, and material...
Eosinophils are major effector cells in diseases including asthma, rhinitis, certain gastrointestinal disorders and atopic dermatitis. Current treatments include mediator antagonists and anti-inflammatory drugs that reduce allergic cell numbers and inhibit mediator release, but they are not fully effective or curative. On their surface, eosinophils selectively express Siglec-8 (sialic acid-binding...
This dissertation asks how a dynamic of vengeance involving the United States and anti-imperialist political organizations in the Middle East emerged and persisted between the 1967 Middle East war and the battle of Tora Bora in Afghanistan in December 2001. It tracks the construction of channels—ideological, institutional, emotional, and personal—through...
The study of tumor metabolism from the middle of the 20th century through the early 21st almost entirely ignored the mitochondria; instead, the field focused on cancer cells use of glycolysis even when oxygen was not limiting, termed aerobic glycolysis. Due to this observation, it was often speculated that malignant...
Photovoltaic technology can help meet the exploding world energy demand in a sustainable and environmentally friendly way. Organic photovoltaics (OPVs) are especially attractive because they can be constructed with low-cost organic content and are amenable to high-throughput large-scale fabrication techniques. Synthetic modification of organic semiconductors has paved way for the...
The renewed scholarly interest in the connections between taxation, state building efforts, and long-term economic development has revitalized the study of historical tax systems. How did today’s states initially acquire ‘fiscal capacity’, and why was this process more successful in some places than in others? Since African tax systems are...
Starting materials for natural products, ideally synthesized using low-cost, highly active and selective catalysts, are of great interest to the pharmaceutical industry. Relevant reactions include the synthesis of 1,2-dihydropyridines, reduction of ketones/aldehydes, cleavage of esters, and reduction of amides to amines. Hydroelementation is an important catalytic process that involves H-E...
This dissertation provides an account of the richest people in Glasgow and Liverpool at the end of the nineteenth and beginning of the twentieth centuries. It focuses on those in shipping, trade, and shipbuilding, who had global interests and amassed large fortunes. It examines the transition away from family business...
As a variety of social capital, scholars’ traditional understanding of a producer’s status is difficult to carry over from one market context to another. However, from organizations seeking to hire rainmakers away from competing organizations within the same markets to producers expanding their offerings into adjacent (and sometimes distant) markets,...
Methanobactins (Mbns) are a growing family of ribosomally produced, post-translationally modified natural products that exhibit a high affinity for copper. These compounds were initially identified in methanotrophic bacteria, which oxidize methane to methanol as their sole source of carbon. One of the key enzymes in this metabolic pathway, particulate methane...
Chemical probes are versatile and unique tools for biomedical research. A chemical probe is simply a selective small-molecule modulator of protein function that allows the user to ask mechanistic and phenotypic questions about its molecular target in biochemical, cell-based or animal studies. Experiments involving selective inhibitors can help delineate key...
This project examines how early modern writers mobilize race as a vehicle for investigating far-reaching epistemological questions about the limits and parameters of human knowledge. While dominant trends in early modern race studies have focused on racial knowledges or particular identifications or formulations of human difference, I break new ground...
In fish, caudally propagating waves of neural activity produce muscle bending moments. These moments, coupled with forces due to the body's elastic properties and forces due to fluid-body interactions, determine the deformation kinematics for swimming. Fully resolved simulations of neurally-activated swimming can be used to decode activation patterns underlying observed...
This dissertation seeks to make sense of the recurring anachronism of aristocracy within early twentieth-century French culture, especially in literature and film. Most studies present the aristocrat as simply one among many examples of the nostalgia, reaction and fascination with the archaic that constituted an important intellectual and artistic tendency...
Victorian novels’ characteristic preoccupation with marriage and inheritance has led scholars to view the form as socially conservative in the mid-nineteenth century. Yet contemporary commentators feared what young women might conceive as a result of reading. The key to this dilemma, I argue, is the usual consequence of nineteenth-century marriage...
This dissertation argues that by examining the networks and advocacy of Americans interested in Lebanon and Lebanese with ties to the U.S., scholars can better understand how relationships cultivated away from the spotlight of policymaker attention have both guided and revealed the limitations of U.S. empire. Activists, both Lebanese and...
“Quartering the Wind” explores the unorthodox, unstable, and seditious political values that undermined early modern English arguments for what is “natural” in human governance. I examine texts that expose a politically intricate natural world that serves no single model of orthodox politics. While ecocritical treatments of political analogies drawn from...
Our visual system organizes lines, shapes, and colors into groups, objects, and scenes. This dissertation explores how these higher-level organizations arise, focusing on the contribution of feature-based attention, our ability to selectively enhance a color, shape, or orientation across our visual field. I will present evidence that feature-based attention enables...
Psychophysiological investigations of human sexuality have revealed more complexity than might be naively assumed. The sexual arousal patterns of heterosexual and homosexual men are relatively straightforward, with both groups showing substantial responses to erotic stimuli of their preferred sex and much smaller responses to their nonpreferred sex. Bisexual men, in...
Metallic nanowires have become functional elements in many electronic devices such as the latest fin-FET (field effect transistor) from Intel, which has metallization layers with pitch as small as 90nm, flexible electronics, touch screens and nanoelectromechanical systems. This wide applicability of nanowires warrants extensive characterization of their fundamental properties such...
Three-dimensional (3D) and two-dimensional (2D) hybrid halide perovskites have emerged as front-runners in solar energy conversion applications with the potential to provide low-cost renewable energy. Being at the interface of chemistry, physics, materials science, and electrical engineering, the field of perovskite solar cells has become a top area of interest...
This dissertation considers the ways do-it-yourself (DIY) urbanism is promoted, taken up, and responded to by the black middle class. Using thirty-eight interviews and one year of ethnographic observation in the Northwest Detroit neighborhood of Bagley, I document the following findings. First, many DIY projects have come from government and...
In this dissertation, we start with the dictionary learning (DL) based single-frame super-resolution (SR) problem, where low resolution (LR) input frames are super-resolved to high resolution (HR) output frames. We propose to extend the previous single-frame SR methods to multiple-frames, i.e., estimating single HR output frame by multiple LR input...
Bulk heterojunction (BHJ) organic photovoltaic (OPV) devices have been extensively studied to achieve power conversion efficiencies well above 10%. New research into alternative materials that allow for cheaper and more industrially viable fabrication of flexible solar cells has been at the forefront of the energy field for the past few...
There is growing interest in and demand for lightweight, age-hardenable alloys such as aluminum (Al) alloys in the transportation sector. This interest is due to the potential for reducing vehicle mass and thereby improving fuel economy. Precipitation microstructures improve the mechanical properties of materials, such as yield stress, by impeding...
Two-dimensional (2D) materials such as graphene exhibit unique, superlative electronic, optical, and mechanical properties that are dictated by the precise atomic structure within each layer. Consequently, control of this atomic-scale configuration is critical to engineering desirable characteristics. To date, however, most 2D materials have been discovered by isolating mono- or...
Allergic diseases, including asthma, atopic dermatitis, and food allergy, are a widespread health issue. The prevalence of these diseases has been increasing, but the mechanism behind this increase and how allergies develop is not well understood. Although the immune system is central to the pathology of allergy, recent work has...
This dissertation explores public and private hybridity in the production of sovereign power, or hybrid sovereignty, through the cases of the English East India Company, Blackwater, International Chamber of Commerce, and Amnesty International. It asks: What forms and dynamics are featured in hybrid sovereignty? What implications does hybrid sovereignty have...
Lewis acids are an important class of catalysts for chemical synthesis and manufacturing. Tris-(pentafluorophenyl)borane (FAB) catalyst has been discovered as an excellent Lewis acid catalyst for a great variety of reactions in organic and organometallic chemistry, particularly for alkoxylation reactions which is relevant to the industrial production of polyether alcohols....
How do creative producers make their works, and how do their social interactions within creative industries shape the creative process? This study addresses these questions by drawing upon two years of ethnographic fieldwork and over 100 interviews with artists, dealers, curators, collectors, and art advisers in the New York City...
Education policy and funding increasingly foster the creation of school partnerships with external stakeholders, such as parents, neighborhood organizations, school district offices, and universities, as a strategy in improving student outcomes. In three independent but related studies, this dissertation sheds light on the specificities rarely addressed by the rhetoric championing...
Since Spanish colonial rule to the present, mining has been one of the main economic activities in the Andes. Taking this fact into account, my dissertation explores how two major Andean countries’ cultural production reacted to mineral wealth exploitation from 1880 to 1930. By analyzing foundational novels and influential journalistic...
Inability to understand speech in the presence of background noise is one of the most common complaints of individuals with hearing impairment. Two hearing aid processing strategies specifically recommended for improved speech perception in noise include: digital noise reduction (DNR) and cognition-based wide dynamic range compression (WDRC) speed. While previous...
The cellular abundance of mature microRNAs (miRNAs) is dictated by the efficiency of nuclear processing of primary miRNA transcripts (pri-miRNAs) into pre-miRNA intermediates. The Microprocessor complex, composed of Drosha and DGCR8 carries this out, but it has been unclear what controls Microprocessor's differential processing of various pri-miRNAs. Here, I show...
This dissertation examines how filmic, literary, and popular musical performances of black female sexualities in the post- civil rights era both reveal and frustrate state-sanctioned infringements on black freedom. “The Paradox of Black Freedom: Black Female Sexuality in Contemporary Performance, 1965-2000” elucidates a powerful paradox wherein the US state enacts...
High-dimensional data are becoming increasingly available in various fields as data collection technology advances. Not only are we interested in knowing which variables are relevant to the response and which are not, but also a simpler model with less predictor variables is easier for interpretation and computational purposes. Furthermore, a...
This dissertation examines the gradual construction and contested meanings of U.S. slavery’s first western border. According to most historiography, Congress’s Northwest Ordinance of 1787 fixed the meaning of this border at the nation’s inception, constituting the Northwest Territory as the free opposite of slave territories south and west of the...
MoS2 is a ubiquitous catalyst for hydrogenation and hydrogenolysis reactions for hydrotreating of petroleum sources for the removal of sulfur and nitrogen containing compounds. Through exploration of this activity, structural models for MoS2 as a series of stacked S-Mo-S platelets held together by Van der Waals forces has been developed....
Education researchers have recently highlighted income achievement and behavior gaps – differences between children from high versus low income families in achievement scores and teacher-rated behavior. To date, scholars in this research stream have not considered the possibility that, compared to white students, non-white students may receive differential returns to...
Across all levels of education, persistent academic achievement gaps exist between students from higher and lower socioeconomic status (SES) backgrounds. Despite these daunting odds, many students from lower-SES backgrounds manage to maintain high levels of academic motivation and persist in the face of difficulty. One factor that has been shown...
Nucleosome organization influences gene activity by controlling DNA accessibility to transcription machinery. In this thesis, we have developed a chemical biology approach to determine mammalian nucleosome positions genome-wide. Using this strategy, we uncover surprising new features of nucleosome organization in mouse embryonic stem cells. In contrast to the prevailing model,...
Woodstock—the word is shorthand for the spirit of the 1960s counterculture. Yet the assumption that the 1960s dawned a “New Age” neglects contributions made by earlier generations of Woodstock artists in advancing a utopian vision of emancipated art, life, and labor. From 1902 onwards, Woodstock—a small Dutch hamlet in upstate...
In the last twenty years, memory entrepreneurs have proliferated memories of Communism from Central and Eastern Europe transnationally across Europe, but for some an invisible Iron Curtain persists. How has the European memory field changed in the last two decades, and more broadly, what determines which mnemonic actors are successful...
Analytic jurisprudence is the field organized around the “What is law?” question. When most scholars approach the “What is law?” question, they suppose that the goal of such inquiry is to discover, or to accurately represent, the true nature of law. Consequently, these scholars reject the notion that the goal...
FOXA1 is a FKHD family protein that plays pioneering roles in lineage-specific enhancer activation and gene transcription. Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of these epigenetic signatures, namely DNA hypomethylation and histone 3 lysine 4 methylation. Mechanistically,...
"Migration Forms” centers on the place where migration and Morocco meet to tell two stories. One argues for the centrality of migration to the projects of local, contemporary art making and postcolonial nation building, while the other examines the codification, circulation, and contestation through visual form of this North African...
An important question in religious and theological ethics concerns the human capacity for moral action, but contemporary Christian theological anthropologies largely theorize the human person in terms of the imago Dei, not moral subjectivity. The following study contributes to this challenge an investigation of human moral agency in the theological...
After 9/11 there was a shift in the rhetoric surrounding counter-terrorism. Suddenly, the language of risk, security and prevention was being utilized to justify a new set of global financial regulations headed up by international organizations such as the United Nations, The Financial Action Task Force, and the IMF/World Bank....
In March 1977 an exceptionally strong earthquake struck Romania ruled by the communist president and dictator Nicolae Ceauşescu and his regime. The policies and actions implemented and undertaken in the days, weeks, and year that followed were forms of aftershocks. The Ceauşescu regime modeled the 1977 earthquake recovery on previous...
Founded in Oakland, California, in 1966 to confront the crisis of anti-black police violence in the Bay Area, the Black Panthers advocated armed struggle against the violences and aggressions of racist American imperialism domestically and internationally. Against interpretations that would deem their image-making to be secondary to their professed political...
This dissertation analyzes theater performances that use narratives of U.S. military veterans in the post 9/11 era in order to cross the military-civilian divide. Engaging theories of performance, embodiment, and affect, this project investigates the depiction of military bodies onstage, the public perception of military identities, and the lived experience...
Our capacity to share ideas through content is the paramount feature of the human brain. All of our species’ advanced communication and coordination fundamentally relies on our ability to “think alike,” yet the parallels between our brains are grossly understudied, especially regarding engagement with dynamic audiovisual stimuli. Therefore, we present...
Recent scholarship in critical urban theory, urban political ecology, and related fields has emphasized the "hybridity" of urban-environmental systems. This argument is contrasted with the socially constructed "binary" relationship between "city" and "nature" that dominated historical understandings of urban-environmental connections. Despite wide agreement on these issues, the trajectories that precipitated...
This dissertation casts an aesthetic light on a selection of polyphonic novels from the Francophone contemporary canon. From the forms of feminism around the prophet of islam in Far from Madina by Assia Djebar, to the multiple voices of Créolité in Solibo Magnificent by Patrick Chamoiseau, to the forms of...
Topoisomerases are ubiquitous enzymes involved in maintaining the supercoiled state of DNA in the cell. Structural, biophysical, and biochemical studies have provided an overall view of the mechanisms of DNA transformation by these enzymes, but many aspects, particularly their dynamic characteristics, remain poorly understood. Type IA topoisomerases change the topology...
“The Vicarious Middle Ages” investigates the religious and cultural history of proxy penance where medieval Christians believed that it was possible to suffer on behalf of another person. In proxy penance, one person completed a penitential work for another, who received the spiritual benefit. From the third until the sixteenth...
Neurocognitive dysfunction, while common among those with schizophrenia, is thought to be exacerbated in violent individuals with schizophrenia and contribute to the commission of violent acts. Few studies have compared performance on neurocognitive measures between violent and nonviolent schizophrenia samples. Better understanding neurocognitive dysfunction in violent individuals with schizophrenia could...
This dissertation investigates the evolution of national identification and assimilative trends among Germans who remained behind in the Czech lands from the end of the postwar expulsions in 1946 through the Czech Republic’s entry to the European Union in 2004. My primary lens of analysis is associational life, or formal...
During the eighteenth century, European trade with Asia was characterized by the importation of sophisticated manufactured goods in exchange for silver. The features of Euro-Asian trade testify to the vitality of the Indian, Chinese, and Japanese economies in the period before the Great Divergence. Many European observers, however, mistook them...
Semiconducting nanoelectronic materials, including single-walled carbon nanotubes (SWCNT) and transition metal dichalcogenides (TMDs) possess interesting optoelectronic properties that could enable next-generation electronics, sensing technologies, and biomedicine. In this thesis, biomolecule-assisted dispersion and assembly of these nanomaterials are explored for human toxicity, environmental hazard potential, and applications in supramolecular hydrogels.
Liquid-based...
This dissertation considers how best to define the imagined “life” of the puppet, and how that “life” offers new meaning to narrative puppet productions. In my first chapter, begin with the observation that puppeteers, scholars, and audiences often describe the puppet as an object that appears to “have life,” and...
Supported metal oxides are an important class of catalysts for chemical synthesis and manufacturing, particularly for selective oxidation reactions. This dissertation seeks to understand broad relationships among families of silica-supported Group 4 and 5 metal oxide catalysts for the synthesis of epoxides with hydrogen peroxide (H2O2) and to further extend...
Regeneration is a complex biological phenomenon. Organisms that regenerate must possess robust mechanisms that direct new tissue production of the appropriate size and pattern to allow for correct and functional integration with preexisting tissue structures. Planarians are flatworms capable of regenerating from nearly any injury, making them a powerful system...
Heterogeneous catalysts play a prominent role in our society, used in applications that range from the production of plastics to the catalytic cracking of crude oil. Industrial catalysts are typically made of mixed metal oxides or nanosized metal particles deposited on high surface area supports. Industrially relevant catalytic materials are...
This dissertation provides the first in-depth comparative study in any language of the female figurations made, viewed, and interpreted in the realm of refashioning modern Chinese painting during the war period of Republican China (1930s-1940s) in the Nationalist government-controlled southwestern inner frontier, with projects by Pang Xunqin (1906–85) and Fu...
Natural products provide a renewable resource of novel chemical structures with relevance to the pharmaceutical, agricultural and materials industries. Genome sequencing has revealed that these industries currently rely on only a fraction of the number of natural products that exist in nature. Based on the impact that known natural products...
Increasing energy demand due to rapid growth in population and industrialization along with environmental crisis has led to the search for cheap, environmentally friendly, and nontoxic methods for generation of energy. However, most alternative energy sources such as photovoltaic, biofuels, hydraulic power, wind power, and geothermal energy, are characterized by...
The anode and cathode are main components in a battery system. In this dissertation, Group IV inter-metallics and LiMn2O4 are studied as anode and cathode materials for Li-ion batteries respectively. Preliminary investigation of a multi-valent cathode material for next generation batteries is also introduced.
Group IV inter-metallics electrochemically alloy with...
The studies presented in this dissertation combine radiogenic and stable strontium isotope ratios (87Sr/86Sr and 88/86Sr, respectively), radiogenic and stable carbon isotope ratios (Δ14C and 13C, respectively), and bulk ion geochemistry to trace the sources and cycling of C in three glaciated environments (New Zealand, Iceland, and Greenland). A primary...
One seismologist’s noise is another seismologist’s signal. What was once disregarded is now routinely processed as dense arrays of broadband seismometers continuously record small amplitude Earth motions, presenting an immense wealth of data. This dissertation presents three projects where ambient seismic noise, generated by ocean wave interactions with the solid...
Greater interest in self-directed professions, like entrepreneurship, have led to a growth in informal workplace communities and social technologies that support new ways of working. However, we have little understanding of how these socio-technical environments support opportunities for professional skill development. The goal of this dissertation is to understand how...
Understanding electrical circuits can be difficult for novices of all ages (Grotzer & Sudbury, 2000; Osborne, 1983; Shipstone, 1984; Tarciso Borges, 1999). Research shows that novices tend to have inadequate understandings of what happens at the level of atoms and electrons, leading to difficulty predicting the outcomes of electrical circuits...
Totipotent cells have the highest developmental potential and can only be created by nuclear transfer into oocytes. Identities of maternal factors that can induce this reprogramming remain a mystery. In this report, we demonstrate induction of totipotency on mouse embryonic stem cells by introducing six factors, Hist1h2aa, H3f3b, H1foo, p-Npm2,...
Wind pollination has evolved from animal pollination at least 65 times in flowering plants, but the reverse transition is rare. Wind pollination is usually accompanied by the loss of traits that attract pollinators, and re-evolving them may be difficult. This dissertation examines this rare transition using Artocarpus (ca. 70 spp.,...
What follows is a strictly post-genomic dissertation. Over the past five years, I have strived to leave the nucleus behind, and even the endoplasmic reticulum and golgi apparatus. The human genome was sequenced over 15 years before the submission of this document, and the world changed somewhat less than anticipated—besides...
This dissertation develops a framework to approach musical hybridity by considering style and genre interactions as an analytical layer of combinations of identities. It engages with the structural, contextual, and perceptual aspects of music by mixing perspectives from music studies with postcolonial studies, situated cognition, and genre studies. Hybridity is...
Many stroke survivors are left with residual movement impairments. Treating these impairments has proven difficult, because it is often unclear which mechanisms drive movement impairment. While the exact mechanisms are still uncertain, at present, evidence suggests that neuromuscular function is disrupted in two key domains following stroke: muscle biomechanics, and...
The expanding use of nanomaterials in consumer products challenges scientists to understand the impact of these materials before their inevitable release into the environment. In the same way that the widespread use of DDT and asbestos has caused unforeseen negative impacts on both the environment and on human health, the...
Psychosocial stress is part of everyday life, and while ubiquitous, stress plays a huge role disease development and treatment. Though the stressor’s intensity, predictability, and frequency (acute vs chronic) are important determinants of disease development, interactions with one’s genetic and epigenetic make-up also play a causal role. Major Depressive Disorder...
Many species have lost their natural habitat due to anthropogenic land use change. Ecologists are increasingly looking at habitat in cities to bolster efforts to conserve biodiversity. Green roofs are examples of urban habitats that are becoming more common globally. Green roofs can provide resources to support life in an...
The Bcl-2 family is considered the guardian of the mitochondrial apoptotic pathway. While there are numerous endogenous Bcl-2 antagonists that share similar homology, structure, topology, and expression pattern, only the loss of Bim in mice is sufficient to lead to the development of a systemic autoimmunity. Even loss of both...
Of the thousands of planetary candidates discovered by the Kepler mission, roughly a third are in known multiple transiting-planet systems. High-multiplicity Kepler systems (referred to as Kepler Multis) are often tightly packed and may be on the verge of instability. Many systems of this type could have experienced past instabilities,...
Most lubricants contain a series of additives that reduce friction and wear, and protect contacting surfaces. The design of these additives must be modernized to meet the challenges involved with high operating temperatures, extreme environmental conditions, and increasingly stringent environmental regulations. This research demonstrates three novel lubricant additive strategies that...
The Pseudomonas aeruginosa type III secretion system delivers effector proteins directly into target cells, allowing the bacterium to modulate host cell functions. ExoU is the most cytotoxic of the known effector proteins and has been associated with more severe infections in humans. Previous studies have shown that ExoU is a...
In the near future, self-driving or driverless vehicles will operate without human control, enabling passengers to use their time in new ways. This opens up avenues for designing new interactions and experiences for individuals or groups traveling in an automobile. For that scenario, automobile manufacturers propose developing bigger and better...
The promise of next-generation electronics, which combines features such as mechanical flexibility, optical transparency, and relatively low-cost, has stimulated tremendous research efforts during the past few years. As perhaps the most fundamental component of an electronic circuit, the design and optimization of the thin film transistor (TFT) is of great...
In vivo, substantia nigra pars compacta (SNc) dopaminergic neurons exhibit three spiking patterns – irregular, regular, and bursting. These distinct modes of activity are thought to underlie the different roles that dopamine (DA) plays in target structures within the basal ganglia. In particular, burst spiking in SNc DA neurons is...