Autism spectrum disorder (ASD) is a heritable, neurodevelopmental disorder characterized by social impairments and restricted and repetitive behaviors (American Psychiatric Association, 2013; Tick, Bolton, Happe, Rutter, & Rijsdijk, 2016), with a subset of first-degree relatives demonstrating a constellation of subclinical traits that are qualitatively similar to the defining features of...
The advent of metamaterials—hierarchical structures that manifest properties beyond those found in nature through geometry rather than material composition—inspired new possibilities and research in many fields. In mechanics, periodic metamaterials exhibit behaviors ranging from unprecedented compressibility to extreme stiffness. Numerous geometric classes of metamaterials with these properties have been discovered,...
In reinforcement learning (RL), an agent aims to learn the optimal policy by interacting with the environment and collecting the reward for each action taken. With the aid of strong function approximators such as the neural networks, RL achieves tremendous empirical successes in various scenarios, including game playing \citep{silver2016mastering, silver2017mastering},...
A central theme in biological anthropology is investigating how the human body responds to interactions with the surrounding environment. The microbiome—the collection of microorganisms (and their genes) that live in and on the human body— represents one such pathway that mediates the environment’s influence on human biology, physiology, and health....
This dissertation explores the mathematics identities of early elementary school students. Throughout school, many students come to believe that mathematics is not for them or is not a part of who they are or want to be. Previous research has revealed mechanisms that lead to negative relationships with mathematics for...
The overall goal of this dissertation, comprised of three empirical studies, was to examine the role of social support as a source of resilience in the face of two chronic stressors: low socioeconomic status and first-generation college student status. Study 1 of this dissertation sought to examine neighborhood support from...
This dissertation considers how 21 trans and queer teenagers learned to create livable lives in unlivable worlds through routine participation on social media. Through a multi-year partnership with an interdisciplinary gender program in Chicago, I employed a humanizing qualitative design anchored by interview and participatory visual methods over three nested...
Nuclear receptors (NRs) are an important family of transcription factors that often regulate genes in response to ligands and by way of direct interactions with coactivator proteins. Many NR-coactivator pairs have been identified that cooperate to regulate transcription but fully understanding how NRs recruit specific coactivators involves learning which of...
Kidney transplantation remains the best and most cost-effective treatment for patients with end stage kidney disease, and the number of kidney transplants performed in the U.S. annually has increased steadily since 2015. To ensure transplant success, kidney transplant recipients (KTRs) are often prescribed lifelong, complex medication regimens that include immunosuppressants,...
We introduce empirical measures to study the $L^2$ norms of restrictions of quantum integrable eigenfunctions to the unique rotationally invariant geodesic $H$ on a convex surface of revolution. The weak* limit of these measures describes the dependence of their size on $H$ in terms of the angular momentum. The limit...
This dissertation aims to rethink how contemporary feminism might grapple with complicity, cooptation, and the concomitant failure of feminist successes through a frame other than paradox. Arguing that the paradox frame locks us into a set of “dead ends,” I shift to an orientation toward spaces between. Through sustained engagement...
Three in ten people worldwide lack access to a safely managed source of drinking water, with one in ten lacking access to a drinking water service altogether. This is projected to worsen in the coming years as climate change, infrastructure degradation, and poor governance work to further increase global water...
Understanding the regulatory programs enabling cancer stem cells (CSCs) to self-renew and drive tumorigenicity could identify new treatments. Through comparative chromatin state and gene expression analyses in CSCs vs. non-CSCs, we identified FOXK2 as a highly expressed stemness-specific transcription factor (TF). Its genetic depletion diminished stemness features and reduced tumor...
Cholinergic modulation of the brain cortex is critical for cognitive processes, and altered cholinergic modulation of the prefrontal cortex is emerging as an important mechanism of neuropathic pain. Despite the known sex differences in pain prevalence and perception, the precise nature of the mechanisms responsible for sexual dimorphism in chronic...
Chromatin is the biological material that packages our genetic information. In humans, 2 meters of linear DNA is compacted into an approximately 6 μm nucleus. Our DNA is transcribed into RNA, which is then translated into proteins. Cellular phenotype, the composite of all cellular functions, is defined by the entire...
Proteins are the nanoscale building blocks of life. Their sophisticated but well-defined architectures result in complex biological functions, including ones involved in metabolism, photosynthesis, transcription, translation, and immunity. To study and improve upon the natural functions of proteins, it is desirable to develop methodology for organizing proteins into targeted architectures....
Contemporary decolonial criticism and critical phenomenological thought may be characterized as proceeding from a disenchantment with the philosophical aspiration towards universality. The overarching argument put forward in this dissertation is that there is, to the contrary, an intimate and even necessary connection between the decolonization of philosophy and the affirmation...
Per- and polyfluoroalkyl substances (PFAS) are man-made compounds containing multiple carbon–fluorine bonds. The unique properties of this strong bond simultaneously make PFAS useful for a number of industrial and consumer applications, toxic to living organisms, and difficult to remediate. Because the pervasive pollution of water sources with PFAS occurs at...
While deep reinforcement learning achieves tremendous successes in practice, its efficiencies are rarely understood in theory. The dissertation contains three parts, with each part corresponding to the study of an independent theoretical reinforcement learning problem. The three parts in all discuss the mechanism of how (deep) reinforcement learning efficiently solves...
Quantum mechanical phenomena are playing tremendous roles in many areas of chemistry and materials science research. In recent years, the potential role of coupling between electronic and vibrational degrees of freedom in photochemical processes has been widely researched. Despite its potential to improve molecular technologies, the lack of studies focusing...
Persons with spinal cord injuries can use state-of-the-art brain-computer interfaces to control robotic arms. Despite this high-tech solution, their movements are slow and imprecise, much like those made by individuals who have lost proprioception, the sense of body position and movement. Intracortical microstimulation (ICMS) used to reactivate neural circuits in...
Organic photovoltaics offer an opportunity to make solar cells more affordable and widely accessible using cheap, solution-processable light-absorbing layers. In order to realize new technologies, a fundamental understanding of organic chromophore photophysics is required to overcome efficiency limitations. Throughout this doctoral work, I investigated the kinetic and physical characteristics of...
Sea urchins are virtuosi of biomineralization, the process by which organisms build mineralized tissues. The embryonic animal exemplifies this with the formation of its endoskeletal spicule. The primary mesenchyme cells (PMCs) undertake spicule synthesis, which involves deposition of the initial granule, elongation of the spicule, and several choreographed changes...
This dissertation contains two topics. The first topic focuses on how to use information design to minimize costs of implementing a policy that guarantees 100% passing rate of all participants by providing enough compensation for the their effort. The second topic explores an auction setting which involves financially distressed business...
The answer to the question “Why do we sleep?” lies in understanding the biological underpinnings of homeostatic drive to sleep. Wakefulness is correlated with numerous changes in brain activity, structure and gene/protein expression that re-normalize following sleep however which of these elements is sufficient to cause sleep drive and how...
Rising social inequality across economic, gender, and racial lines is a pressing issue of our time. Despite widespread agreement that inequality exists, there are stark ideological disagreements about its extent, its victims, and about what – if anything – should be done to address it. Prior work demonstrates that the...
Seasonal malaria chemoprevention (SMC) was first recommended by the World Health Organization (WHO) in 2012 to prevent uncomplicated malaria in children and began implementation in Burkina Faso in 2014 under programmatic campaigns. Systematic assessment of the impact of national SMC campaigns requires data with weekly or monthly temporal resolution over...
This thesis develops novel methods for generating space-filling designs inside a designspace and subsampling from a data set. It incorporates materials from two papers by the
author: Shang and Apley 2021; Shang, Apley, and Mehrotra 2022a. Chapter 1 discusses space-filling designs of computer experiments, which is publishedas Shang and Apley...
The field of time-domain astronomy has seen significant advancements in the latest years as increasingly sensitive, deep and wide-field surveys of the sky at all wavelengths are being carried out more and more frequently. Furthermore, the addition of gravitational wave detectors around the world has opened an entirely new window...
Optical coherence tomography (OCT) images the retina noninvasively with micrometer-scale volumetric resolutions. It is an invaluable resource in the clinic for identifying, monitoring, and treating blindness-causing diseases. By shortening illumination wavelengths to the visible range, visible-light OCT (vis-OCT) improves image resolution, provides new scattering contrasts, and enables oxygen saturation (sO2)...
Slow-moving landslides are common in mountainous area worldwide. Most of them mobilizes slowly over long periods of time, which causes continuous damage to proximal infrastructure and habitats. Most notably, some slow-moving landslides can experience catastrophic acceleration at some point in their life cycle, with potentially fatal consequences. It is therefore...
Research over the past several decades has revealed that memory reactivation in sleep contributes to the formation of long-lasting memories. Among the most recent developments in this field is the widespread use of the technique of targeted memory reactivation (TMR), which allows researchers to induce reactivation of specific memories during...
The purpose of this thesis is to derive three results in probability theory. The first is a proof that small powers of the normalized absolute characteristic polynomial of a random matrix sampled from either the Gaussian Orthogonal or Symplectic Ensemble converges in law to a Gaussian multiplicative chaos measure. The...
Photochemistry is an inherently interdiscplinary field where very large energies are leveraged for the making and breaking of bonds. My work has broadly dealt with various strategies to control how energy delivered by light can be channeled into useful functions. I developed a strategy to control the chemo- and stereo-selectivity...
Wearable visual systems, such as ego-centric wearable cameras, have failed to integrate into everyday life. We have witnessed the abandonment of wearable visual systems as consumer devices (e.g., Google Glass) and as research tools (e.g., SenseCam). While it is natural for some technologies to die out, visual wearable systems are...
Listeners can experience strong and often positive identification with music. Contemporary research has emphasized the importance of a listener’s own identity, including their sense of self and their desires, when forming such identifications. However, acknowledgments of the listener’s role in the listening experience have failed to productively engage discussions of...
Van der Waals, or layered, materials offer a flexible platform to tune properties via exfoliation down to the single- or few-layer limit; they are at the forefront of cutting-edge materials science and engineering research because of the innumerable ways to tune materials as a function of thickness or composition. Due...
This thesis contains two research projects. The first research project examined the coherent nature of electron transfer in two donor-acceptor dyads – one single acceptor control compound and one dual acceptor molecule of interest. Using transient absorption spectroscopy in the ultraviolet/visible/near-infrared and mid-infrared regions, magnetic field effect experiments, and theoretical...
Today’s romance fiction landscape is drastically different than the early 1980s when its community of readers and writers formalized in the Romance Writers of America and Romantic Times fan magazine. Then, romance fiction was understood to focus on “the interaction between male and female.” Today, romance depicts a variety of...
Flexible sheet metal forming processes possess significant potential in today’s industrial goods market with the advent of the next generation manufacturing paradigm, which put stresses on products customization and cost efficiency. However, due to the unique tooling configurations and forming mechanisms adopted in different flexible sheet metal forming processes, there...
In this dissertation, we aim to develop algorithms that achieve optimality with provable complexity guarantees under various settings in reinforcement learning (RL). Specifically, in Markov decision processes (MDPs), we study single-agent and multi-agent online RL, respectively, and offline RL under the presence of unobserved confounders. Single-agent online RL. We design...
New capabilities in x-ray microscopy have been enabled by rapid advances in synchrotronlight sources and in high performance computing. We present here conceptual and computational
advances in two areas of x-ray microscopy. One involves ptychography, where computation is
used to obtain images from diffraction patterns as a finite coherent illumination...
Granular materials are ubiquitous in nature and play a prominent role in countless technologies. The mechanical responses of multiphase granular material can vary significantly, when imposed to differential loading rates, depending on confinement, loading type and pore fluid properties. In this thesis, a versatile modelling platform is developed for delineating...
Meiosis is a specialized form of cell division that occurs to generate sperm and eggs with unique sets of paternal or maternal DNA; this process shuffles genetic information to promote the amazing variation that we observe in living organisms. In order to carry out two rounds of DNA separation with...
This thesis presents a new self-assembling robotic system that diverges from traditional approaches by enabling robots to build structures not constrained to a lattice and formed based on environmental conditions, rather than on a priori blueprints. Robot self-assembly is a class of behavior in swarm robotics in which many robots...
The provision of social services is becoming increasingly complex as human service agencies, nonprofits, and government agencies recognize the importance of wraparound care. A wraparound approach to social service provision acknowledges the importance of providing comprehensive services that meet various individual, family, and community needs. This approach is enacted through...
In recent years, machine learning on graphs (or networks) has gone from a niche topic with only a few active researchers worldwide, to a heavily invested field with novel use cases for dealing with relationships and/or interactions within complex systems in the natural and social sciences. Traditionally, choosing the right...
Aristotle says that true assertions in practical philosophy are true “for the most part.” I argue an assertion is true “for the most part” if it refers to the hypothetical realization of a substance’s essential capacities under some set of impediments. The removal of impediments to the full realization of...
The construction of new C–C bonds remains a central facet of organic chemistry due to its critical role in the synthesis of pharmaceutical compounds and organic materials. Mild and selective methodologies are often required for efficient formation of these bonds in natural product total synthesis, medicinal chemistry campaigns, and more....
Over the course of disease progression, half of adults with type II diabetes also develop diabetic peripheral neuropathy (DPN), peripheral nerve damage precipitated by the downstream metabolic effects of hyperglycemia, insulin resistance, and dyslipidemia. This multifactorial pathogenesis of DPN leads to various structural and physiological changes within the nerve, ultimately...
Perturbations to the physiology or impairments in the formation of synapses within the cochlea, specifically the ribbon synapses, result in decreased sensitivity to auditory stimuli. In example, prolonged exposure to moderately intense auditory stimuli, like power tools, can result in the swelling of nerve terminals, retraction of the postsynaptic membrane,...
Originally motivated by the emergence of networked systems lacking central coordination such as multiprocessors, wireless sensor networks and smart grids, the study of distributed optimization algorithms has been an active field of research spanning multiple decades. More recently, the rapid growth in the availability of high-dimensional datasets has posed the...
“Where Do We Come From? What Are We? Where Are We Going?” is the name for one of French artist Paul Gauguin’s most influential paintings. Unsurprisingly, these very questions have occupied the minds of countless philosophers, artists, and scholars since the beginning of human civilization. These questions become especially salient...
This dissertation is a case study of one midwestern city and its Latinx inhabitants. It explores the intertwined pursuit by ethnic Mexicans and Puerto Ricans of inclusion in union and electoral politics. The world of machine politics offered ethnic Mexicans and Puerto Ricans an avenue for inclusion. Central to this...
X-ray imaging at nano and micro-scale is of great importance for the material science and defense industry. Large penetration depth and low wavelength of x-rays offer an important potential to image objects at high resolution and in a non-invasive process. While the ever-growing community is pursuing novel applications and looking...
Existing scholarship documents the low levels of political power held by the American poor, and concomitant economic elite domination of Congress. Since the poor seldom elect lawmakers that share their descriptive traits, they necessarily rely on non-poor lawmakers virtually representing their interests. A key part of this virtual representation is...
Stress, trauma exposure, and posttraumatic stress disorder (PTSD) are associated with chronic health conditions. In the U.S., women of color face trauma at up to four times the national rate. They also contend with chronic stress from the intersectional hardships of racism, discrimination, sexism, and economic hardship that is the...
Individuals experience a wide variety of emotions in their everyday lives. Some experience more variety, or complexity, than others, called emotional complexity. There is a body of research that suggests that emotional complexity is beneficial for mental and physical health; yet more recent work has called these associations into...
My dissertation defends a hermeneutic conception of ideology and its critique that situates both in the world-disclosing function of language.I argue that we must conceive of ideologies as world-disclosing embodied interpretive schemas insofar as they guide our cognitive, affective, and conative access to reality by providing the background knowledge, meanings,...
This dissertation examines the remediation of video game music from their source games to the concert hall. I argue that while not unique in their repositioning from popular to classical registers, the classicalization of video game music offers a contemporary challenge to the current norms of classical music institutions. I...
Pattern formation of biological structures involves the arrangement of different types of cells in an ordered spatial configuration. Patterning is thought to involve the spatial organization of molecular pre-patterns that precede and drive subsequent cell differentiation and coinciding morphogenesis. These molecular prepatterns are often, although not exclusively, organized through Turing...
Visual Question Answering (VQA) increasingly attracts industry and academia attention. It requires the model to provide a natural language answer by an image and a related natural language question. Meanwhile, it relates to multidisciplinary research such as natural language understanding, visual information retrieval, and multimodal reasoning. As a multimodality task,...
Cuteness is a popular aesthetic in product design, yet there is a lack of understanding of who is most likely to engage in cute consumption and, more importantly, why. In this dissertation, I consider the role of sex and gender identity in cute consumption, proposing a strong mental association between...
Imagine sitting in a room listening to some friends play a song. Perhaps one friend is playing guitar, another playing bass, and a third is playing drums. The musical content in this scene is extraordinarily complex, yet it contains many types of structure that is easy for us to comprehend....
Laser powder-blown directed energy deposition (DED) is an additive manufacturing process that utilizes a co-axial nozzle and laser to melt metal powders onto a substrate in a line-by-line fashion. This coupling gives rise to interactions between the laser, powder, and melt pool. To address fundamental process understanding, physical models were...
Polymer and polymer/ceramic composites known as bone cements are commonly used in musculoskeletal reconstructive surgeries where bone tissue fixation, reinforcement, or void filling may be needed. Polymethylmethacrylate, PMMA, was the initial (and currently only) FDA-approved bone cement for bone-void filling applications yet faces many inherent material-based challenges that impacts its...
This dissertation purposely prioritizes Tibetan and Himalayan tsunmas’ perspectives on the topic of restoring a full ordination lineage for ordained women. To do so, it examines the gendered landscapes of Buddhist women’s ordination, which has been a contentious issue throughout Buddhism’s twenty-six-hundred-year history, beginning with the Buddha’s eventual acceptance of...
The increasing availability of large-scale scholarly datasets offers an unprecedented opportunity to understand the fundamental predictability, uncertainty, and dynamics of science and innovation. In this dissertation, I present some of my contributions to the science of science and innovation in three distinct but related settings, through a combination of canonical...
Granular materials consisting of discrete particles, are a pervasive material in nature and play a major role in disparate fields of science and technology. To control and manipulate the granular materials in engineering, enriching our understanding of their fundamental characteristics and mechanical behavior is crucial. In this context, one of...
The worldwide community of patients affected by Basal Cell Carcinoma of the skin (BCC) is larger than that of any other cancer. While BCC is rarely lethal, currently available treatment strategies often leave patients with disfiguring scars on their faces, heads, and necks. Moreover, the high recurrence rates of BCC...
In this dissertation, I provide insight into different aspects of the law and politics of trade secrecy at four levels of analysis. Part I examines trade secrecy from an international and comparative perspective. It encompasses Chapters 2 and 3 and focuses on (#1) international law and (#2) comparative national policy....
This dissertation examines anti-Black race-based ideologies prevalent in early American musical theatre through a multi-faceted case study concerning Morgan Benson, a child actor of the early musical theatre stage, Target Parades of the long nineteenth-century, and The Black Joke. This is an excavation project, seeking to unearth conceptual underpinnings for...
This dissertation analyzes how suburban school districts made sense of and planned to reduce inequality between 2019–2021. Previous literature has found that suburban schools, despite their reputation as the best in the country, are deeply unequal (Lewis and Diamond 2015; Lewis-McCoy 2014). Building on this previous scholarship, I ask: How...
The intersection of sound design and music scoring has been employed expressively in contemporary Mexican cinema to convey complex social commentary. This dissertation investigates how the Mexican films Vuelven, Sin Señas Particulares, and Sanctorum exploit the potentials of the soundtrack to create politicized aesthetic experiences. My research is in dialogue...
With growing system complexity and closer cyber-physical interaction, there are stronger needs for cyber-physical systems to adapt to the dynamic environment and improve their runtime performance. However, especially for safety-critical systems, the ability of such adaptation and improvement is often restricted by multiple factors, such as limited resources, stringent timing...
In the seventeenth and eighteenth centuries, hundreds of Venetian women began musical training in childhood to become professional musicians, known as figlie di coro (daughters of the choir), in the four charitable Ospedali Maggiori. These women overcame childhood poverty and abandonment to awe prestigious guests with their skills and even...
This thesis consists of three chapters: two are empirical studies of policy design in small-business lending markets, while the final is a large-scale retrospective of retail mergers. Chapter 1 examines moral hazard in loan guarantee programs. To address credit constraints in small-business lending markets, policymakers frequently rely on loan guarantees,...
Cancer is a top leading cause of deaths worldwide, among which pancreatic cancer and liver cancer are top leading cause of cancer-related deaths. Despite recent developments in cancer treatment, pancreatic and liver cancers still have a high mortality and low life expectancy, especially when diagnosed at advanced stages. Earlier cancer...
This dissertation studies three aspects of healthcare market regulation.
Chapter 1 studies the optimal design of quality scores for health insurance plans. Regulators often generate quality scores to help consumers with limited information about product quality, as in schooling, healthcare, and financial markets. When designing scores, regulators must not only...
With the ever-increasing demand for more complex functionalities and miniaturization of photonic devices, the design of such devices requires a whole new different approach, deviating from classical photonic design approaches. Conventionally, the design of a typical photonic device starts with a prior knowledge, intuition, and practical experience of specific behavior...
This paper studies the joint importance of dissemination and the structure of firms’ information networks in the pricing of value relevant financial information. I first document that disruptions to the dissemination of information on Twitter.com cause the market to react less to earnings news. Using ten staggered Twitter outages, which...
In the adult hippocampus of many mammalian species, populations of newborn dentate granule cells (DGCs) are continuously generated and undergo subsequent activity-dependent neuronal maturation and incorporation into the preexisting hippocampal circuitry. Increasing evidence has demonstrated that these young adult-born DGCs (abDGCs) participate in numerous cognitive and affective processes such as...
My research at northwestern with Dr. Christina Zelano focused on the human amygdala subnucleithat receive monosynaptic input from the olfactory bulb. Surprisingly little is known
about these brain regions, including their potential roles in olfactory and nonolfactory
processing. During my PhD, I completed three projects aimed at furthering our understanding...
This dissertation develops a causal theory of the relevant alternatives in a situation and applies this theory to the semantics and epistemology of conditionals, the theory of knowledge, and the epistemology of stereotyping. The first chapter presents the theory of causal models and causal alternatives. The second chapter applies this...
Missing data are often described as an annoyance in research and generally presented as a source of error or bias during analysis. To this end, methods that center on planned missingness are an underappreciated and powerful tool that can actually be used to improve data collection and the validity of...
For stochastic simulation optimization in a modern computing era, we introduce a new parallel framework for solving very large-scale problems using a ranking & selection (R&S) approach that simulates all systems or feasible solutions to provide a global statistical guarantee. We propose a parallel adaptive survivor selection (PASS) framework that...
Myoelectric pattern recognition-based upper limb prostheses measure electromyographic (EMG) signals from the residual limb and learn to identify muscle activity patterns that correspond to intended gestures. To train an accurate pattern recognition controller, it is essential that the training signals typify signals measured in real-world scenarios. When these conditions are...
Individual responses are an important determinant of public policy effectiveness. Development policies often try to remove barriers that limit the ability to make the preferred choices, hoping that this will lead to prosperity at the individual and aggregate levels. However, removing some, but not all, barriers can lead to undesirable...
This dissertation centers gay and lesbian activists, their lawyers, and public interest litigation organizations in a genealogical understanding of the evolution of human rights law in the LGBTIQ+ issue space. I ask why sexual minorities turned to the courts in pursuit of the decriminalization of homosexual sex. Empirically, I examine...
Ensuring adequate water quality is essential for human health and for effective allocation of resources in agriculture, energy, and manufacturing. However, the current state-of-the-art for water quality testing requires expensive equipment and technical expertise to analyze samples and takes days to obtain results from off-site labs, making it inaccessible to...
Wearable-based human activity recognition is well-studied in the machine learning and pervasive computing community. A large corpus of studies focused on using wearable sensors to recognize health-related behaviors that involve high periodicity in the sensed signal, such as sitting, walking, and running. Other activities that occur less frequently throughout the...
SAMDI-MS, which stands for self-assembled monolayers (SAMs) for matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS), is a powerful tool that has enabled the development of novel high-throughput screening and experimentation methods for decades. SAMDI-MS works by immobilizing analytes to functionalized SAMs prior to MS analysis and is capable of...
Reproduction requires a complex orchestration of processes from the formation of the reproductive system through the successful development of the fetus, and nutrients are necessary to fuel these processes during many aspects of reproduction. Zinc is an essential metal that is fundamental in gamete maturation, gonadogenesis, and fertilization. Disruption in...
No two cells in a population are identical to each other. Cell populations are almost universally heterogeneous, with their heterogeneity or variability often underlying complex emergent behavior and phenotypes. Heterogeneity presents a challenge to the discovery, characterization, and control of multicellular systems. Heterogeneity exists across multiple scales, ranging from the...
The first chapter of the dissertation analyzes a moral hazard problem where a firm incentivizes a team of complementary workers in the presence of trust concerns. As we show, when concerned about team members not trusting each other, the firm typically sacrifices statistically-relevant information, compensating some workers based solely on...
In most markets, consumers of goods and services have vastly more options available to them than they will consider closely. At the point of making a decision, consumers are choosing between only a small subset (i.e., a consideration set) of all possible alternatives. The preceding process that forms these consideration...
Over 10 billion tons of concrete are produced for the construction industry every year, making concrete the second most used substance on Earth, only surpassed by water. With such high importance as a building material, there is significant need for the ability to accurately model concrete behavior. As a quasi-brittle...
Anxiety and depression are highly prevalent, recurrent, and major public health problems. Decades of research has uncovered associations between symptom dimensions of anxiety and depression and abnormal neural activation across executive control-, threat-, and reward-related networks. Recent studies have developed a hierarchical symptom structure of anxiety and depression termed the...
The development of functional materials with rationally designed hierarchical structure is an interdisciplinary challenge. Looking to nature for inspiration, we use small molecules that
engage in directed self-assembly through carefully tuned intermolecular interactions to construct
materials that have structure at multiple length scales. In this work, supramolecular structures
formed using...
From energy to materials, hydrocarbon chemistry drives our world. Stemming from the petrochemical industry, our understanding of CxHy combinations has allowed society to flourish, and hydrocarbons will likely remain valuable species in our future even as we transition to greener carbon and hydrogen sources. Currently, one of the most efficient...