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-
- Description:
- Regulatory T (Treg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumor immunity. Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of proinflammatory properties, can promote autoimmunity and/or facilitate more effective tumor immunity. A comprehensive understanding...
- Keyword:
- Tumor, Treg, Ubiquitin, Foxp3, Usp21, and Usp22
- Subject:
- Biology, Cellular biology, and Immunology
- Creator:
- Montauti, Elena
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_846345 and http://dissertations.umi.com/northwestern:15780
-
- Description:
- Halide perovskites, AMX3 (A = monocation, B = Ge, Sn, or Pb, and X = halogen), present a versatile class of solution-processable semiconductors made from earth abundant materials with outstanding electrical and optical properties. Their solar cell efficiencies have dramatically increased from ~9% to ~22% in less than five years...
- Keyword:
- solar cells, semiconductors, halide perovskites, and two-dimensional
- Subject:
- Chemistry
- Creator:
- Duyen Hanh Cao
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 04/02/2018
- Date Modified:
- 04/02/2018
- Date Created:
- 2017-01-01
- Resource Type:
- Dissertation
-
- Description:
- NiTi shape memory alloy (SMA) has drawn a great deal of attention for its various applications in the medical field (orthodontics, cardiovascular stents technology, etc.) and in other engineering fields (aerospace, aircraft, automotive, etc.) as it shows shape memory effect, superelasticity and biocompatibility. The fatigue-related issues, however, are pronounced in...
- Subject:
- Materials Science
- Creator:
- Liu, Chuan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_794898 and http://dissertations.umi.com/northwestern:15461
-
- Description:
- In this thesis we study minimal measures for Lagrangian systems on compact manifolds. This thesis consists of three parts which are closely related. The first part is Chapter 3 and Chapter 4. In Chapter 3 and 4, we consider geodesic flows on compact surfaces with higher genus. We show that...
- Keyword:
- Minimal Measures
- Subject:
- Mathematics
- Creator:
- Fang Wang
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 10/02/2018
- Date Modified:
- 10/02/2018
- Date Created:
- 2008-08-22
- Resource Type:
- Dissertation
-
- Description:
- The idea of the unity of audition and vision has been a topic of interest since the time of ancient Greece. Investigation of this idea has continued to grow in many areas, especially in psychology, music, visual art, and computer science, most notably since the invention of the world's earliest...
- Keyword:
- match between auditory and visual parameters, audio-to-visual instruments, transformation algorithms, and constant-Q filter bank analysis
- Subject:
- Music Theory
- Creator:
- Mikyung Kim
- Owner:
- Jason Christ Chandra
- Date Uploaded:
- 09/16/2018
- Date Modified:
- 09/16/2018
- Date Created:
- 2008-10-22
- Resource Type:
- Dissertation
-
- Description:
- The semiconductor-based Quantum Cascade Laser (QCL) offers several key advantages over gas lasers, solid-state lasers, and other semiconductor-based mid-infrared lasers. While the QCL has historically operated best in the λ ~ 7-9 μm range using InP-based materials, a major challenge has been to achieve a high-power, room-temperature continuous-wave (CW) operation...
- Keyword:
- Gas Source Molecular Beam Epitaxy MBE, intersubband, Compound Semiconductor, Mid-Infrared Laser, InP, and Quantum Cascade Laser
- Subject:
- Electrical and Computer Engineering
- Creator:
- Allan Joseph Evans
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 09/14/2018
- Date Modified:
- 09/14/2018
- Date Created:
- 2008-05-22
- Resource Type:
- Dissertation
-
- Description:
- The overall objective of this thesis is to develop a package of high-resolution, non-invasive experimental and numerical approaches to observe in situ pore-scale geometry modification due to colloid deposition, and quantitatively predict its effects on the large-scale transport properties of the porous medium. High-energy synchrotron-based X-ray difference micro-tomography (XDMT) was...
- Keyword:
- Civil Engineering
- Subject:
- Civil and Environmental Engineering
- Creator:
- Cheng Chen
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 09/13/2018
- Date Modified:
- 09/13/2018
- Date Created:
- 2008-07-22
- Resource Type:
- Dissertation
-
- Description:
- Funding risky Research and Development (R&D) and New Product Development (NPD) projects is crucial for the long term health of any large company. Such funding decisions are multiobjective and are undertaken with sparse data. Therefore prescriptive or algorithmic solutions are not adopted by practitioners. Descriptive solutions that provide managerial insights...
- Keyword:
- Industrial
- Subject:
- Industrial Engineering and Management Sciences
- Creator:
- Souvik Banerjee
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 09/13/2018
- Date Modified:
- 09/13/2018
- Date Created:
- 2008-05-22
- Resource Type:
- Dissertation
-
- Description:
- Visual object tracking, i.e. consistently inferring the motion of a desired target from image sequences, is a must-have component to bridge low-level image processing techniques and high-level video content analysis. This has been an active and fruitful research topic in the computer vision community for decades due to both its...
- Keyword:
- Context-awareness, Visual Attention, Computer Vision, Multiple Target Tracking, Video Processing, and Visual Tracking
- Subject:
- Electrical and Computer Engineering
- Creator:
- Ming Ying
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 09/06/2018
- Date Modified:
- 09/06/2018
- Date Created:
- 2008-05-22
- Resource Type:
- Dissertation
-
- Description:
- This dissertation analyzes the transformation of fantasy sports from a deviant, outside-the-mainstream fan culture to a billion-dollar industry that comprises almost 20 million North American participants. Fantasy sports are games in which participants adopt the simultaneous roles of owner, general manager, and coach of their own teams of real athletes...
- Keyword:
- sports, popular culture, audience studies, and fan culture
- Subject:
- Media, Technology and Society
- Creator:
- Ben Shields
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 09/06/2018
- Date Modified:
- 09/06/2018
- Date Created:
- 2008-04-22
- Resource Type:
- Dissertation
-
- Description:
- Inactivation of tumor suppressors genes, which encode regulatory proteins critical for maintaining normal cellular function, is a common occurrence in cancer. Ikaros is a hematopoietic-specific zinc finger protein that functions as a differentiation regulator and has properties of a tumor suppressor. Ikaros functions to regulate gene expression as a component...
- Keyword:
- Notch, Ikaros, tumor suppressor, and RBP-J
- Subject:
- Integrated Graduate Program in the Life Sciences
- Creator:
- Katie L Kathrein
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 09/01/2018
- Date Modified:
- 09/01/2018
- Date Created:
- 2008-02-22
- Resource Type:
- Dissertation
-
- Description:
- A comprehensive understanding of how image processing occurs in the primary visual cortex (V1) requires learning what aspects of neuronal responses are driven by strong feed-forward input from the lateral geniculate nucleus (LGN), and what aspects arise due to the densely recurrent network operating within the cortex itself. From an...
- Keyword:
- Neuroscience and Biology
- Subject:
- Neuroscience Institute Graduate Program
- Creator:
- Ian Micah Finn
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 08/16/2018
- Date Modified:
- 08/16/2018
- Date Created:
- 2007-10-22
- Resource Type:
- Dissertation
-
- Description:
- The first chapter of this dissertation investigates the pricing of systematic variance risk in the equity options market. Cross sectional tests on synthetic variance swap returns reveal no evidence of a negative market variance risk premium. Furthermore, we show that a class of linear factor models cannot simultaneously explain index...
- Keyword:
- dispersion trading, pairs trading, correlation trading, equity options, variance swaps, and volatility forecasting
- Subject:
- Finance
- Creator:
- Vadim di Pietro
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 08/16/2018
- Date Modified:
- 08/16/2018
- Date Created:
- 2007-06-22
- Resource Type:
- Dissertation
-
- Description:
- This work investigates children's early semantic representations of gradable adjectives (GAs) and proposes that infants perform a probabilistic analysis of the input to learn about abstract differences within this category. I first demonstrate that children as young as age three distinguish between relative (e.g., 'big', 'long'), maximum standard absolute (e.g.,...
- Keyword:
- semantics, word learning, comparison, language acquisition, adjectives, and adverbs
- Subject:
- Linguistics
- Creator:
- Kristen L Syrett
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 08/14/2018
- Date Modified:
- 08/14/2018
- Date Created:
- 2007-08-22
- Resource Type:
- Dissertation
-
- Description:
- Surfaces and interfaces, which are ubiquitous in the environment, control the mobility,speciation, and ultimate fate of groundwater species. The presented work provides insight into the interfacial behavior of three environmental pollutants: hexavalent chromium, oxytetracycline, and morantel. Model surfaces are employed for these studies, including (1-102) α-Al<sub>2</sub>O<sub>3</sub> and a carboxylic acid-terminated...
- Keyword:
- Physical and Chemistry
- Subject:
- Chemistry
- Creator:
- Michael Joseph Musorrafiti
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 08/13/2018
- Date Modified:
- 08/13/2018
- Date Created:
- 2007-08-22
- Resource Type:
- Dissertation
-
- Description:
- Activin, a member of the TGF-b superfamily, controls a variety of physiological events from the cell cycle to reproductive health. Activin activates the Smad signaling pathway through ActRII/B and ALK4 receptors. The regulation of activin signaling is carried out in part by the inhibitor protein follistatin. The mechanistic details of...
- Keyword:
- Biology and Molecular
- Subject:
- Interdepartmental Biological Sciences Program
- Creator:
- Thomas F Lerch
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 08/07/2018
- Date Modified:
- 08/07/2018
- Date Created:
- 2007-08-22
- Resource Type:
- Dissertation
-
- Description:
- This study investigates the causes and welfare consequences of unravelling in two-sided matching markets. "Unravelling" arises when agents contract with one another at an early stage, before much of the relevant information is available. Such early matches may lead to ex-post inefficiencies and are perceived as socially harmful. This study...
- Keyword:
- Economics and Theory
- Subject:
- Economics
- Creator:
- Hanna Wieslawa Halaburda
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 08/06/2018
- Date Modified:
- 08/06/2018
- Date Created:
- 2007-06-22
- Resource Type:
- Dissertation
-
- Description:
- Local structure determination in amorphous and disordered systems, which are crystallographically intractable, is critical for gaining an understanding of their properties. X-ray absorption spectroscopy (XAS) is an excellent tool for local structure determination in amorphous and disordered environmental materials. Amorphous manganese oxides produced by the freshwater bacterium Leptothrix discophora SP6...
- Keyword:
- Biogenic manganese oxides
- Subject:
- Chemistry
- Creator:
- Ian Saratovsky
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 05/10/2018
- Date Modified:
- 05/10/2018
- Date Created:
- 2006-12-22
- Resource Type:
- Dissertation
-
- Description:
- This dissertation presents submillimeter polarimetry methods and scientific results. The scientific results focus on revealing the magnetic field structure of giant molecular clouds (GMCs). The basic principles, instrumentation, observing strategy, and data analysis methods of submillimeter polarimetry are introduced. The scientific data were acquired by SPARO during the observing campaign...
- Keyword:
- Physics
- Subject:
- Physics and Astronomy
- Creator:
- Hua Bai Li
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 05/10/2018
- Date Modified:
- 05/10/2018
- Date Created:
- 2006-12-22
- Resource Type:
- Dissertation
-
- Description:
- Reactivation of latent human cytomegalovirus is of significant concern in immunocompromised transplant patients. However, the mechanisms controlling reactivation of latent CMV have not been understood. It is likely that reactivation is initiated by induction of IE gene expression. In this thesis, I studied molecular mechanisms leading to transcriptional activation of...
- Keyword:
- Microbiology and Biology
- Subject:
- Integrated Graduate Program in the Life Sciences
- Creator:
- Soo Jung Kim
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 05/10/2018
- Date Modified:
- 05/10/2018
- Date Created:
- 2006-12-22
- Resource Type:
- Dissertation
-
- Description:
- Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique that can detect single molecules and simultaneously obtain structural information. When an analyte molecule binds to a nanostructured noble metal surface, the otherwise weak normal Raman signal is enhanced by as much as a factor of 108. This makes SERS the...
- Keyword:
- Surface-Enhanced Raman Spectroscopy and single molecule spectroscopy
- Subject:
- Physical chemistry and Nanoscience
- Creator:
- Wong, Nolan Log-chi
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14406 and etdadmin_upload_617842
-
- Description:
- This dissertation contains three empirical studies in economic history and labor economics. The first chapter discusses two sources of historical data on work stoppages in the United States: the Third Annual Report of the Commissioner of Labor (1888) and the Tenth Annual Report of the Commissioner of Labor (1896). It...
- Subject:
- Economic history and Economics
- Creator:
- Bittarello, Luca
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14721 and etdadmin_upload_669611
-
- Description:
- Substance abuse is one of the most critical public health problems affecting juvenile detainees. Previous research suggests that a significant proportion of juvenile detainees with substance use disorders do not receive treatment prior to or during detention. Using data from the Northwestern Juvenile Project, a large-scale longitudinal study of juvenile...
- Keyword:
- Psychology
- Subject:
- Clinical Psychology
- Creator:
- Leah Paskar
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 10/01/2018
- Date Modified:
- 10/01/2018
- Date Created:
- 2008-11-24
- Resource Type:
- Dissertation
-
- Description:
- The purpose of this mixed methods study was to learn about the ways that instrumental music teachers in Chicago navigate the urban landscape. The design of the study most closely resembles Creswell and Plano Clark's (2007) two-part Triangulation Convergence Mixed Methods Design, with the addition of an initial exploratory focus...
- Keyword:
- mixed methods, urban, music education, Chicago, music teaching, and instrumental music
- Subject:
- Music Education
- Creator:
- Kate R. Fitzpatrick
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 09/07/2018
- Date Modified:
- 09/07/2018
- Date Created:
- 2008-05-09
- Resource Type:
- Dissertation
-
- Description:
- The morphological evolution due to coarsening is analyzed for two distinctive types of microstructure. First, the feasibility of characterizing spatial correlations of interfacial curvature in topologically complex structures is demonstrated with the analysis of bicontinuous two-phase mixtures produced using phase field modeling. For structures produced with both conserved and nonconserved...
- Keyword:
- interfacial curvature
- Subject:
- Materials Science and Engineering
- Creator:
- Amber Lynn Genau
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 10/03/2018
- Date Modified:
- 10/03/2018
- Date Created:
- 2008-09-02
- Resource Type:
- Dissertation
-
- Description:
- This thesis is organized into three essays, each with particular insights involving public policy and family formation: In the first essay, I address the well-documented correlation between the prestige of the university and the labor market income of its graduates by investigating whether a possible medium for this effect is...
- Keyword:
- College Major, Education, Marriage, Financial Aid, and Divorce
- Subject:
- Economics
- Creator:
- Benjamin Walter Bohdan Passty
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 09/18/2018
- Date Modified:
- 09/18/2018
- Date Created:
- 2008-07-01
- Resource Type:
- Dissertation
-
- Description:
- This dissertation addresses the process-pathways running between immigrant adolescents' life experiences and their engagement in school by providing an ecocultural perspective on self-regulation. While the role of social context, such as stress and resources, has been identified as critical in its influence on different dimensions of adolescent development, research on...
- Keyword:
- Development, Problem Solving, Adolescence, Stress, Self-Regulation, and Culture
- Subject:
- Education and Social Policy - Learning Sciences
- Creator:
- Helen Julia Eksner
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 06/25/2018
- Date Modified:
- 06/25/2018
- Date Created:
- 2007-05-15
- Resource Type:
- Dissertation
-
- Description:
- The leptonic and inclusive hadronic decay branching fractions of the W boson are studied using 35.9 $fb^{-1}$ of proton-proton collision data collected at $\sqrt{s}=13~TeV$ during the 2016 run of the CMS experiment. Events characterized by the production of pairs of W bosons from \ttbar and \tW processes are selected. Multiple...
- Keyword:
- lepton flavor universality, W boson branching fraction, and CMS
- Subject:
- Physics and Particle physics
- Creator:
- Chen, Ziheng
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15758 and etdadmin_upload_845225
-
- Description:
- Recent discoveries in vitamin D research indicate that vitamin D is a necessary component to several organs and tissues that extends beyond bone formation Furthermore, recent research indicates that vitamin D deficiency is rampant across the globe. Historically, anthropological research has focused on the adaptive significance of skin color to...
- Keyword:
- Philippines, developmental biology, Vitamin D, biological anthropology & human biology, gender & sex, and epigenetics
- Subject:
- Physical anthropology, Public health, and Developmental biology
- Creator:
- Perez, Julianna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15568 and etdadmin_upload_818816
-
- Description:
- Despite prevention and treatment, substantial risk for cardiovascular disease(CVD) remains in the population and CVD has been the leading global cause-of-death in past years.While high-density lipoprotein (HDL) markers such as HDL cholesterol (HDL-C) and HDL efflux (a cholesterol-transport-function assay) are associated with decreased risk of CVD, the mechanism of this...
- Keyword:
- Cardiovascular Disease, Apolipoproteins, Post-translational Modifications, Proteoforms, and Top-down Proteomics
- Subject:
- Chemistry
- Creator:
- dos Santos Seckler, Henrique
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_791345 and http://dissertations.umi.com/northwestern:15443
-
- Description:
- This dissertation contains three essays. In the first essay, "The Role of Connections in Congressional Lawmaking", I investigate the role of connections in congressional lawmaking by studying how legislators' deaths impact their peers' capacity to sponsor and advance bills in the U.S. House of Representatives. I focus on legislators who...
- Subject:
- Economics and Political science
- Creator:
- Garro Beraza, Haritz
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_723511 and http://dissertations.umi.com/northwestern:15026
-
- Description:
- Breast cancer cells acquire many genetic alterations in apoptotic signaling pathways rendering them resistant to apoptosis. Human Epidermal growth factor Receptor-2 (HER-2/ErbB2/neu) is amplified or overexpressed in approximately 30% of breast and ovarian tumors and correlates with poor prognosis. Although HER-2 is an orphan receptor, it forms potent signaling heterodimers...
- Keyword:
- HER-2/neu, apoptosis, BH3, caspase substrates, and breast cancer
- Subject:
- Integrated Graduate Program in the Life Sciences
- Creator:
- Anne Marie Strohecker
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 07/30/2018
- Date Modified:
- 07/30/2018
- Date Created:
- 05-15-2007
- Resource Type:
- Dissertation
-
- Description:
- PilD is an enzyme that processes prepilins that are part of the type II protein secretion apparatus and the type IV piliation machinery. Using a <em>Legionella pneumophila pilDlacZ</em> fusion strain to measure transcription, we observed a 20% increase in beta-galactosidase levels at 30°C vs. 37°C. At 25°C and 17°C vs....
- Keyword:
- Microbiology and Biology
- Subject:
- Integrated Graduate Program in the Life Sciences
- Creator:
- Maria Soderberg
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 09/06/2018
- Date Modified:
- 09/06/2018
- Date Created:
- 2008-03-25
- Resource Type:
- Dissertation
-
- Description:
- Recently, much public attention has been focused on racial inequalities in who is subjected to exclusionary school disciplinary policies, and consequently, forced to miss hours of instruction. Over the past two decades, researchers have documented the disparate impacts that zero-tolerance policies have had on students of color, low-income students, and...
- Keyword:
- mixed methods, School suspensions, and causal inference
- Subject:
- Human Development and Social Policy
- Creator:
- Ijun Lai
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 10/28/2019
- Date Modified:
- 10/28/2019
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
-
- Description:
- Chapter 1 investigates asks the question how do financial frictions affect the type of human capital investments that students make in college? To study this question, I build a novel dataset covering more than 700,000 U.S. students, merging commencement records with address histories, credit bureau records, and professional resumes. I...
- Subject:
- Education finance
- Creator:
- Hampole, Menaka Vagesh
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_986815 and http://dissertations.umi.com/northwestern:16605
-
- Description:
- Early life adversity predicts greater health risk in later life across multiple outcomes, including cardiovascular disease (CVD) and all-cause mortality. While biological pathways are incompletely understood, evidence is increasingly highlighting immune function, specifically chronic inflammation, which is implicated in cardiometabolic diseases, certain cancers, and all-cause mortality. Links between early adversity...
- Subject:
- Physical anthropology
- Creator:
- Aronoff, Jacob
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_945998 and http://dissertations.umi.com/northwestern:16356
-
- Description:
- Chapter 1. Undergraduate Gender Diversity and Direction of Scientific Research (with Francesca Truffa) Can diversity lead to greater research focus on populations underrepresented in science? Diverse researchers can bring new questions and perspectives, but exposure to diversity may also inspire scientists, regardless of demographic identity, to pursue new topics. This...
- Subject:
- Labor economics
- Creator:
- Wong, Ashley
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_899059 and http://dissertations.umi.com/northwestern:16019
-
- Description:
- This work is composed of two separate projects that contribute to the field’s understanding of Neisseria gonorrhoeae genetics and physiology. First, I showed that N. gonorrhoeae mounts a substantial transcriptional program in response to hydrogen peroxide (HP), a prominent reactive oxygen species (ROS) encountered during infection. We measured which strain...
- Keyword:
- Bacterial genetics, Microbiology, Neisseria gonorrhoeae, and Bacteriology
- Subject:
- Microbiology
- Creator:
- Quillin, Sarah Jane
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14977 and etdadmin_upload_716337
-
- Description:
- Evolutionary theory predicts that reproduction entails energetic costs that detract from somatic maintenance, accelerating biological aging. In women, such ‘costs of reproduction’ (CoR) are thought to arise predominantly during pregnancy and lactation, while in men the physiological effects of the steroid hormone testosterone (T) are believed to be a major...
- Keyword:
- Epigenetic clocks, Tradeoffs, Disposable soma theory, Costs of reproduction, Aging, and DNA methylation
- Subject:
- Genetics, Evolution & development, and Biology
- Creator:
- Ryan, Calen Patrick
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_780539 and http://dissertations.umi.com/northwestern:15395
-
- Description:
- The high-temperature oxidation/reduction behaviors of iron and its oxides are important to a variety of energy conversion and storage technologies, such as the solid-oxide iron-air battery and chemical looping combustion. The useful lifetime of iron redox materials is limited, however, by structural degradation arising from (i) sintering, accelerated by phase...
- Subject:
- Materials Science
- Creator:
- Wilke, Stephen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15073 and etdadmin_upload_741055
-
- Description:
- Type IIb supernovae (SNe) are important candidates to understand mechanisms that drive the stripping of stripped-envelope (SE) supernova (SN) progenitors. ', 'While binary interactions and their high incidence are generally cited to favor them as Type IIb SN progenitors, this idea has not been tested using models covering a broad...
- Keyword:
- Astrophysics
- Subject:
- Physics and Astronomy
- Creator:
- Niharika Sravan
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 10/28/2019
- Date Modified:
- 11/20/2019
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
-
- Description:
- Post-transcriptional gene silencing (PTGS) and, more specifically, RNA interference (RNAi) include the processes by which a small double-stranded RNA, 19 to 22 nucleotides (nts) long, negatively regulates the expression and/or translatability of a target RNA, which harbors reverse complementarity to that small RNA, by recruiting the so-called RNA-Induced Silencing Complex...
- Keyword:
- siRNA, RNA Interference, Cell Death, Cancer, shRNA, and DISE
- Subject:
- Driskill Graduate Training Program in Life Sciences
- Creator:
- William Edward Putzbach
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 04/01/2019
- Date Modified:
- 04/01/2019
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
-
- Description:
- Background: Cancer-related cognitive impairment (CRCI) is among the most frequently reported adverse events during and following cancer treatment. Between 17% to 75% of chemotherapy-treated cancer patients evidence long-term cognitive deficits as many as 20 years after treatment. The variability in prevalence and the mechanisms of persistent CRCI are not well...
- Keyword:
- mild cognitive impairment, ADNI, Cancer-related cognitive impairment, cancer, Alzheimer's disease, and Aging
- Subject:
- Oncology, Clinical psychology, and Aging
- Creator:
- Eastman, Jennifer Ann
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_677366 and http://dissertations.umi.com/northwestern:14756
-
- Description:
- Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions – providing a powerful system to study prionization. Previously, the Li Lab demonstrated that Swi1, a component of the SWI/SNF chromatin-remodeling complex, can form the prion [SWI+]. A small region,...
- Keyword:
- [SWI+], yeast, protein aggregation, prions, Saccharomyces cerevisiae, and Swi1
- Subject:
- Molecular biology, Bioinformatics, and Neurosciences
- Creator:
- Goncharoff, Dustin Kenneth
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_816388 and http://dissertations.umi.com/northwestern:15538
-
- Description:
- Abstract The overall purpose of this paper is to reconsider the narrative usage and function of a literary phenomenon like ‘opposition/tension/contradiction.’ Throughout my analysis of Alain-Robbe Grillet’s La jalousie, Chloé Delaume’s J’habite dans la television and Jean Genet’s Le Balcon I was focused on investigating the use of this phenomenon...
- Subject:
- French literature
- Creator:
- Costea, Mihaela-Adina
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_639270 and http://dissertations.umi.com/northwestern:14518
-
- Description:
- A greater number of strategies in one’s coping repertoire (i.e., the number of diverse strategies used across stressors or use habitually across several situations) may be beneficial and a precursor to coping flexibly across situations (Bonnano & Burton, 2013). Indeed, previous studies have demonstrated a benefit of having larger number...
- Keyword:
- coping and well-being
- Subject:
- Psychology
- Creator:
- Bastarache, Emily Diane
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_855481 and http://dissertations.umi.com/northwestern:15815
-
- Description:
- Of the half million new cases of invasive cervical cancer (ICC) reported globally each year, over 80% occur in Low-and Middle-Income Countries (LMICs)1. Nigeria is one of these countries with a huge burden of ICC incidence and mortality.2 As reported in the Global Burden of Cancer 2013, cervical cancer is...
- Keyword:
- Abnormal cervical cytology outcome, Cervical Cancer Screening, HIV status, Nigeria, Provider recommendation, and Opportunistic screening
- Subject:
- Health Sciences Integrated PhD Program
- Creator:
- Jonah Musa
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 10/08/2019
- Date Modified:
- 10/08/2019
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
-
- Description:
- Human skin oils are significant scavengers of atmospheric oxidants in occupied indoor environments. Many techniques used to study gas-phase transformations of surface films indoors have been limited to off-line bulk analysis, although more surface-selective methodologies are emerging. Here, we present a multi-prong analytical approach to characterizing skin oil ozonolysis. Skin...
- Keyword:
- squalene, nonlinear spectroscopy, ozonolysis, indoor air, optical profilometry, and surface science
- Subject:
- Physical chemistry and Chemistry
- Creator:
- Butman, Jana Lee
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16586 and etdadmin_upload_986300
-
- Description:
- The Operating System (OS) kernel is a key component of modern computing infrastructure, yet it is prone to numerous vulnerabilities, many of which cause memory corruptions that can be exploited by attackers to perform malicious activities. While various techniques have been introduced to secure the Linux kernel, it still constantly...
- Keyword:
- Weird machine, Kernel vulnerability, Exploitation, and Exploitability
- Subject:
- Computer science
- Creator:
- Lin, Zhenpeng
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1010237 and http://dissertations.umi.com/northwestern:16700
-
- Description:
- In the first two decades of the twenty-first century, we have witnessed a surge of public interest in and discussion around racial reckoning. Universities in the United States and across the globe are grappling with their historical associations with transatlantic and chattel slavery. This dissertation takes up the question of...
- Keyword:
- reconciliation, abolition, family, rhetorical analysis, redress, and Black feminism
- Subject:
- Gender studies and Rhetoric and Composition
- Creator:
- Ferrell, Ashley P
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16749 and etdadmin_upload_1013545
-
- Description:
- Metal-organic frameworks (MOFs) are porous, crystalline materials synthesized by combining metal nodes and organic linkers through self-assembly. The diverse range of building blocks available allows for extensive tunability of MOFs, enabling the optimization of these materials for various applications, such as gas storage, separations, and catalysis. This study aimed to...
- Keyword:
- Molecular modeling, Xylene Separation, Monte carlo simulation, Chemical engineering, and Metal-organic framework
- Subject:
- Chemistry and Chemical engineering
- Creator:
- Li, Zhao
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1013711 and http://dissertations.umi.com/northwestern:16763
-
- Description:
- Glioblastoma (GBM) is the most common aggressive primary malignant brain tumorin adults with a median age of onset of 65 years of age. Although advanced age is often associated with worse GBM patient survival, the predominant source(s) of maladaptive aging effects remains to be established. Here we studied intra-tumoral and...
- Keyword:
- Senescence, p16INK4a, Glioblastoma, Aging, and Immunotherapy
- Subject:
- Biology and Neurosciences
- Creator:
- Bell, April Charlotte
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16795 and etdadmin_upload_1016132
-
- Description:
- Metal–Organic Frameworks (MOFs) is a class of material comprising organic linkers and inorganic, metal-ion-containing nodes, with diverse functionalities and wide-range of applications. Because of their porous nature and functional nodes and linkers, they are competent candidates for gas storage, separation, catalysis, and so on. Most MOFs, however, are intrinsically insulating,...
- Keyword:
- Metal–Organic Frameworks, Electrochemistry, and Electrocatalysis
- Subject:
- Analytical chemistry, Chemistry, and Materials Science
- Creator:
- Duan, Jiaxin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16539 and etdadmin_upload_984686
-
- Description:
- In recent years, we have seen the embryo of Industry 4.0 which has been promoting manufacturing processes towards the future with better efficiency, higher accuracy and better reliability. However, manufacturing precision has been restricted by the precision of metrology and material characterization. In other words, one can only manufacture parts...
- Keyword:
- Digital Image Correlation, Metrology, Industry 4.0, Photometric Stereo, and Deep Learning
- Subject:
- Mechanical engineering
- Creator:
- Yang, Ru
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16719 and etdadmin_upload_1012433
-
- Description:
- Stairs and curbs often present as an exhausting environmental barrier for individuals with bilateral cerebral palsy (CP) due to their lower limb motor impairments. Indeed, performance in stair-climbing in this population has a higher correlation with disruption of mobility than walking. Community members affected by CP consider impaired mobility a...
- Subject:
- Physical therapy, Biomedical engineering, and Biomechanics
- Creator:
- Goyal, Vatsala
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16701 and etdadmin_upload_1010522
-
- Description:
- Anthropologists engaging with biopolitical theory have commonly assumed that biomedicine is a tool for enacting state-based policies to manage population health. Recent insights in medical anthropology have troubled this assumption, calling into question the role of physicians as “handmaidens” of state-based health policy. I use my position as a physician-anthropologist...
- Keyword:
- anthropology of reproduction, pregnancy, opioid use disorder, illicit substance use disorders, biopolitics, and medical anthropology
- Subject:
- Cultural anthropology
- Creator:
- Premkumar, Ashish
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_965675 and http://dissertations.umi.com/northwestern:16433
-
- Description:
- The role of providing care for a loved one with Alzheimer’s disease can expose friends and family caregivers to significant stress over an extended period of time, resulting in a host of negative outcomes like increased depression and anxiety, and diminished quality of life. However, previous studies have found that...
- Keyword:
- psychological well-being, positive emotion, caregiving, online intervention, Alzheimer's disease, and eHealth
- Subject:
- Clinical psychology, Health sciences, and Psychology
- Creator:
- Kwok, Zhenting Ian
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16329 and etdadmin_upload_941336
-
- Description:
- This thesis document is comprised of three research projects. The first investigates the active vibrational modes involved in twisted intramolecular charge transfer in a Julolidine-BODIPY dyad using two-dimensional electronic spectroscopy along with DFT calculations. We identified two types of vibrations, compression and torsional motion, as playing an important role in...
- Subject:
- Organic chemistry, Physical chemistry, and Chemistry
- Creator:
- Fisher, Jeremy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16773 and etdadmin_upload_1014057
-
- Description:
- Renewable energy technology, more so than ever before, is critical to the survival of humanity. For decades, concentrated efforts into designing and developing such novel devices resulted in the innovation of solar-driven photovoltaics that were competitive with nonrenewable alternatives. This thesis explores the dynamic behavior of alternative material candidates that...
- Keyword:
- electronic, structural, perovskite, spectroscopy, two-dimensional, and nanomaterials
- Subject:
- Physics, Chemistry, and Materials Science
- Creator:
- Panuganti, Shobhana
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1010644 and http://dissertations.umi.com/northwestern:16703
-
- Description:
- The work presented in this thesis is to describe the fabrication of the nano-composites of carbonaceous materials (e.g. graphene oxide) and metal oxides (e.g. Titanium dioxide TiO2) for two specific applications in the field of public health protection: 1.) removal of micropollutants (MPs) in the aqueous environment; 2.) antimicrobial coating.The...
- Subject:
- Environmental engineering
- Creator:
- Fu, Han
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1013991 and http://dissertations.umi.com/northwestern:16770
-
- Description:
- The need for complex and sophisticated materials continues to grow as society becomes more advanced. For many chemists, the design of these materials begins by looking towards model molecular systems for the identification of desirable properties and functions. As such, restricting oneself to C, H, N, O, and the other...
- Keyword:
- metal-organic frameworks, Magnetic materials, stimuli-responsive materials, weak link approach, and coordination polymers
- Subject:
- Inorganic chemistry
- Creator:
- Coleman, Benjamin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16793 and etdadmin_upload_1015421
-
- Description:
- Each neuron in the primary motor cortex (M1) is like a musician in an orchestra, contributing to a larger harmony under the constraint of a “neural manifold”—a geometric score describing the correlated signals produced by the neural musicians that drive movement. Despite the widespread recognition of the importance of M1...
- Keyword:
- neural networks, neural manifolds, motor control, machine learning, and brain-computer interface
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Altan, Ege
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1001502 and http://dissertations.umi.com/northwestern:16658
-
- Description:
- Interpenetrating polymer networks (IPNs) are multicomponent materials that enhance the compatibility of otherwise immiscible polymers by trapping the microstructure in a non-equilibrium state. By combining polymers with vastly different moduli, IPNs effectively disperse rigid polymers within a soft matrix, resulting in a reinforced elastomer. This approach significantly increases the modulus...
- Keyword:
- Phase Seperation, Polymer Physics, Silicone Elastomer, Interpenetrating Polymer Networks, and Single Molecule Localization Microscopy
- Subject:
- Polymer chemistry, Plastics, and Chemical engineering
- Creator:
- Heyl, Tyler
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1001901 and http://dissertations.umi.com/northwestern:16662
-
- Description:
- Large scale adoption of sustainable technologies for energy productionand storage can be greatly facilitated by scientific advances impacting efficiency, cost and availability. The study of materials is instrumental in both upgrading the performance of existing technologies and enabling the development of new ones, and ab-initio methods and machine learning represent...
- Subject:
- Materials Science and Energy
- Creator:
- Baldassarri, Bianca
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16729 and etdadmin_upload_1012768
-
- Description:
- Chronic stress is a significant risk factor for the development of numerous psychiatric disorders, including major depressive disorder (MDD). Individuals with MDD exhibit impairments in reward processing and decreased motivation to engage in previously-rewarding activities. Importantly, there is a large sex disparity in MDD diagnosis, such that it affects nearly...
- Keyword:
- corticosterone, motivation, and dopamine
- Subject:
- Neurosciences
- Creator:
- Holloway, Ashley
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16726 and etdadmin_upload_1012569
-
- Description:
- The rise in children’s media use (Rideout & Robb, 2020) and the prioritization of STEM learning (Fayer et al., 2017) has led to the development of new STEM-related apps, TV shows, and other media for young children. One topic in this area gaining popularity is computational thinking (CT). Researchers refer...
- Keyword:
- Diversity, Culture and Inclusion, Computational Thinking, Early Childhood, Educational Television, and STEM
- Subject:
- Developmental psychology, Science education, and Communication
- Creator:
- Lemley, Breniel
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1011152 and http://dissertations.umi.com/northwestern:16709
-
- Description:
- A proliferation of new media platforms have upended the traditional roles that journalists have played in society, placing their work into content streams that are populated by creators who mimic the surface features of their work but not their methods. As a result, journalists’ practices and news media that they...
- Keyword:
- News Literacy, Pedagogy, Journalism Education, Boundary Setting, and Constructivism
- Subject:
- Journalism, Educational philosophy, and Education
- Creator:
- Spikes, Michael Antonio
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1009657 and http://dissertations.umi.com/northwestern:16690
-
- Description:
- In this dissertation, we aim to develop a theoretical understanding of foundation models and reinforcement learning. We delve into a comprehensive analysis of specific aspects within these domains. The focal points of our study are as follows: • Generative Adversarial Imitation Learning (GAIL) with Neural Networks: GAIL is poised to...
- Keyword:
- Reinforcement Leanring, In-Context Learning, Imitation Leanring, and Transformer
- Subject:
- Statistics and Operations research
- Creator:
- Zhang, Yufeng
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1013414 and http://dissertations.umi.com/northwestern:16740
-
- Description:
- Rivers and streams play a critical role in connecting major global carbon pools – land, oceans, and atmosphere. The longitudinal flow in rivers and streams allows for the integration and transport of fluvial particulate organic carbon (POC) from various sources and its continual transformation. A continuum-oriented perspective suggests longitudinal variations...
- Keyword:
- biomarker, particulate organic carbon, storm, stream, and agricultural watershed
- Subject:
- Environmental science and Biogeochemistry
- Creator:
- Kim, Jieun
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16775 and etdadmin_upload_1014167
-
- Description:
- Kaposi’ sarcoma-associated herpesvirus (KSHV) causes primary effusion lymphoma (PEL). PEL cell lines require expression of the cellular FLICE inhibitory protein (cFLIP) for survival, although KSHV encodes a viral homolog of this protein (vFLIP). Cellular and viral FLIP proteins have several functions, including, most importantly, the inhibition of pro-apoptotic caspase 8...
- Keyword:
- cFLIP, DR4, TRAIL-R1, cell death, HHV-8, and primary effusion lymphoma
- Subject:
- Microbiology and Biology
- Creator:
- Kuehnle, Neil Joseph
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16705 and etdadmin_upload_1010776
-
- Description:
- The relationship between the structure and function of proteins is a fundamental problem in biology with implications for the future of biotechnology and global health. For example, changes to the structure of a coronavirus spike protein led to a global pandemic where our best defenses were vaccines that could only...
- Subject:
- Materials Science
- Creator:
- Waltmann, Curt
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16624 and etdadmin_upload_991536
-
- Description:
- Scholarly inquiry has yielded a wealth of evidence in support of narrative-based strategies for persuasion, and yet support for this approach is less consistent in relation to contentious or controversial issues. To better understand why this might be the case, the first part of this dissertation reports a theoretically-guided content...
- Keyword:
- media effects, narrative, abortion, message format, narrative persuasion, and persuasion
- Subject:
- Mass communication and Communication
- Creator:
- Brooks, John Jennings
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1013586 and http://dissertations.umi.com/northwestern:16755
-
- Description:
- Prisoner reentry has become an increasingly popular topic of research in the past few decades due to the phenomenon of mass return as a result of the era of mass incarceration. While research has been done on the experiences of the returning population before mass incarceration, few contemporary researchers have...
- Keyword:
- War on Poverty, prisons, religion, and reentry
- Subject:
- History, Criminology, and Sociology
- Creator:
- Brown, Karlia Nicole
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16671 and etdadmin_upload_1004192
-
- Description:
- Ankle sprains are the most common musculoskeletal injury. After an ankle sprain, about 40% of individuals develop Chronic Ankle Instability (CAI), resulting in recurrent sprains, the ankle giving way, or feelings of instability. Most sprains occur due to excess inversion of the ankle. Frontal-plane ankle stiffness quantifies the ankle’s ability...
- Subject:
- Biomedical engineering and Biomechanics
- Creator:
- Villamar, Zoe Dahlia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16668 and etdadmin_upload_1002685
-
- Description:
- “National Acts: Performance, Commemoration, and the Construction of American Public Memory” explores how sites of public commemoration created during and after the American Civil War crafted conceptions of American public memory and identities through performative processes. This dissertation looks at three commemorative efforts: the Freedmen’s Memorial Monument to Abraham Lincoln,...
- Keyword:
- public memory, performance studies, American culture, and public commemoration
- Subject:
- Theater history, American studies, and Museum studies
- Creator:
- Bryer, Rebekah M
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16732 and etdadmin_upload_1012939
-
- Description:
- Dental enamel is a complex bio-composite with compositional and structural features across a wide range of length scales. Defects in these features can compromise enamel’s ability to protect the tooth, resulting in adverse health outcomes. Acquired defects like tooth decay are familiar to most people and are the subject of...
- Keyword:
- Amelogenesis, Enamel, Neural networks, X-ray diffraction, Microcomputed tomography, and Mouse models
- Subject:
- Materials Science
- Creator:
- Cooley, Victoria Mae
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16769 and etdadmin_upload_1013954
-
- Description:
- Many processes in nature and human-made settings rely on the unique properties of charged metal oxide:aqueous interfaces. Despite their ubiquity, these buried interfaces are challenging to study, since any analytical technique aiming to overcome the relatively small number density of interfacial versus bulk species must be highly sensitive and surface-selective....
- Keyword:
- solid aqueous interface, second harmonic generation, nonlinear optical spectroscopy, metal oxide, heterodyne detection, and hematite
- Subject:
- Physical chemistry, Geochemistry, and Chemistry
- Creator:
- Lozier, Emilie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16725 and etdadmin_upload_1012560
-
- Description:
- Caves are accessible windows into the shallow subsurface, serving as transitional ecosystems between the photosynthesis-dependent surface and the deeper subsurface. Without a source of solar energy to ultimately power carbon (C) fixation (photolithoautotrophy), cave ecosystems are either reliant on surface-derived nutrients, recovering reducing power from the microbial oxidation of redox-sensitive...
- Keyword:
- caves, network analysis, microbial ecology, and biogeochemistry
- Subject:
- Microbiology, Bioinformatics, and Geobiology
- Creator:
- Selensky, Matthew James
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_993827 and http://dissertations.umi.com/northwestern:16627
-
- Description:
- Global dementia diagnoses are steeply increasing. While advances in neuroimaging, neuropathology, and genetics research have improved our understanding of neurodegenerative diseases causing dementia, precise antemortem diagnosis, as well as sensitive and specific biomarkers that can facilitate a differential diagnosis and aid in participant recruitment in clinical trials, remains elusive. The...
- Subject:
- Clinical psychology
- Creator:
- Stocks, Jane
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_993222 and http://dissertations.umi.com/northwestern:16626
-
- Description:
- This dissertation explores critiques of mass education alongside the rise of the research university as they appear in the early writings of Friedrich Nietzsche and Walter Benjamin. More specifically, it traces the development of a theory of (un)learning that inserts distance into the pedagogical relation to produce a discretized educational...
- Keyword:
- Bildung, Nietzsche, Education, Benjamin, Youth Movement, and Pathos of Distance
- Subject:
- German literature and Philosophy
- Creator:
- Laport, Theodore F.
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1013555 and http://dissertations.umi.com/northwestern:16750
-
- Description:
- Cancer is a complex and heterogeneous disease characterized by aberrant gene regulation. Gene regulation is fundamentally orchestrated by the 3D genome organization which involves chromatin looping, compartmentalization, and the formation of topologically associating domains (TADs). Structural variations (SVs), such as genomic rearrangements, deletions, inversions, and duplications, are commonly observed in...
- Subject:
- Bioinformatics and Biology
- Creator:
- Wang, Juan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16734 and etdadmin_upload_1013045
-
- Description:
- This dissertation explores how dominant U.S. constructions of race, class, and gender are embedded into and inscribed onto artificially intelligent virtual assistants and the labors they perform. I examine virtual assistants like Amazon’s Alexa, Apple’s Siri, and Microsoft’s Cortana, interrogating their complex relationship to humanness, the tasks they are programmed...
- Keyword:
- haunting, media, labor, Black, domestic, and technology
- Subject:
- African American studies, Gender studies, and Film studies
- Creator:
- Owens, Golden M.
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16772 and etdadmin_upload_1014053
-
- Description:
- This thesis explores how beyond-the-Standard-Model physics interactions could lead to the detection of neutrino decay with lifetimes that are orders of magnitude smaller than a second. I mainly focused on right-handed neutrino fields, new heavy states, and non-zero daughter neutrino masses, assuming the neutrinos are Dirac fermions. An extensive description...
- Keyword:
- Visible, Invisible, Neutrino, and Decay
- Subject:
- Theoretical physics
- Creator:
- Weill, Jean
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16720 and etdadmin_upload_1012443
-
- Description:
- Clustering is a fundamental task in unsupervised learning, which aims to partition the data set into several clusters. It is widely used for data mining, image segmentation, and natural language processing. One of the most popular clustering methods is centroid-based clustering, including k-medians and k-means clustering. k-medians and k-means clustering...
- Keyword:
- Decision Tree, Clustering, Explainability, and k-means
- Subject:
- Computer science
- Creator:
- Shan, Liren
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16717 and etdadmin_upload_1012370
-
- Description:
- This dissertation focuses on the study of the superionic state in multicomponent systems, where the smaller component exhibits delocalization and mobility while still maintaining system compactness through component attractions. Superionic behavior is widely observed in various systems and plays a crucial role in ceramic superionic conductors, which offer high ion...
- Keyword:
- electrostatics, charge transport, sublattice melting, phase transition, superionic behaviors, and colloidal crystals
- Subject:
- Physical chemistry, Chemistry, and Condensed matter physics
- Creator:
- Lin, Yange
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16697 and etdadmin_upload_1009942
-
- Description:
- One of the greatest challenges in heterogeneous catalysis is the rational design and development of new catalytic systems, due to synthetic limitations in the design of solid catalysts and inhomogeneity of chemical sites at solid surfaces. This obfuscates understanding of catalyst behavior and slows improvements of processes. One approach to...
- Subject:
- Inorganic chemistry, Chemistry, and Chemical engineering
- Creator:
- Hicks, Kenton
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_996080 and http://dissertations.umi.com/northwestern:16635
-
- Description:
- Clean water supplies are required for industry and general life. However, water shortages dueto pollution and human activity are increasingly common, and new, more efficient, materials need to be made to increase clean water supplies. To do this, fundamental information on the interaction of water with ions at the atomic...
- Subject:
- Chemistry and Computational chemistry
- Creator:
- Felts, Alanna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1010659 and http://dissertations.umi.com/northwestern:16704
-
- Description:
- The functions of lubricants in moving interfaces are extensive; lubricants minimize friction, transfer heat, clean the rubbing surfaces, extract debris, and diminish wear. Rather than using separate lubricants for each of the functions, it is more desirable to make one lubricant serve multiple purposes, or a muti-functional lubricant. The goals...
- Keyword:
- Atomistic modeling of lubricants, Pour point, Tribopolymerization, Thermal conductivity, Tribology, and Interfacial tribochemistry
- Subject:
- Mechanical engineering
- Creator:
- Ahmed, Jannat
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16670 and etdadmin_upload_1004183
-
- Description:
- Morality has been viewed as a core aspect of the self and even a basic psychological need. Strategies for regulating threats to moral self-views may therefore be distinct from regulating threats to other self-aspects. Consistent with research on the regulation of basic psychological needs, I hypothesized that threats to the...
- Keyword:
- compensatory consumption, symbolic self-completion, self-affirmation, moral self, self-threat, and psychological needs
- Subject:
- Social psychology
- Creator:
- Yetzer, Andrea M.
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16711 and etdadmin_upload_1011962
-
- Description:
- The continuing increase in atmospheric CO2 to concentrations exceeding 400 ppm has attracted considerable attention from both scientists and policymakers. Industrial fossil fuel consumption generates a significant amount of CO2 emissions, and in particular, energy-intensive molecular separations that require thermal processes, such as distillation, drying, or evaporation, are responsible for...
- Keyword:
- Dimensionality, Noble Gases, Hexane, Xylene, Metal-Organic frameworks, and MOFs
- Subject:
- Inorganic chemistry, Chemistry, and Materials Science
- Creator:
- Idrees, Karam
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_991974 and http://dissertations.umi.com/northwestern:16625
-
- Description:
- Performing complex reasoning has been a long-standing challenge in artificial intelligence (AI).This thesis describes a class of AI systems designed to reason, extract knowledge, and answer questions on various domains such as process understanding, elementary science, and math word problems. Our approach differs from traditional logical reasoning systems since we...
- Keyword:
- Knowledge Extraction, Natural Language Processing, Artificial Intelligence, Explainable Artificial Intelligence, Question-answering, and Reasoning
- Subject:
- Computer science
- Creator:
- Neves Ribeiro, Danilo
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16640 and etdadmin_upload_997812
-
- Description:
- Lignin is the largest store of renewable aromatic carbon. Due to its refractory nature, however, its chemical potential is not fully realized, rather, most lignin is treated as a waste, burned for low-value energy. Here, we propose a biorefinery where the treatment of wastewater by a microbial electrolysis cell (MEC)...
- Keyword:
- Biorefinery, Antioxidants, Flavonoids, Lignin, and Lignin Nanoparticles
- Subject:
- Environmental engineering
- Creator:
- Obrzut, Natalia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16684 and etdadmin_upload_1008684
-
- Description:
- In shared workspaces users have real-time access to others’ actions, allowing greater access to potentially informative cues. However, there has been little exploration about what impact the ability to view each other’s work in real time has on group members’ perception of both each other and their understanding of the...
- Subject:
- Cognitive psychology, Sociolinguistics, and Experimental psychology
- Creator:
- Elliott, Arielle
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16759 and etdadmin_upload_1013679
-
- Description:
- The COVID-19 pandemic disrupted the status quo of the telemobility landscape in the United States, forcing millions of Americans into lock down, significantly changing the way we work, travel, and spend our time and money for an extended period of time. After several months of adaptation, adoption, learning, and unlearning,...
- Keyword:
- latent variable modeling, e-commerce, covid-19, longitudinal tracking, telemobility, and telework
- Subject:
- Transportation and Civil engineering
- Creator:
- Tahlyan, Divyakant
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16722 and etdadmin_upload_1012495
-
- Description:
- Assistive robots have the potential to support motor recovery after an injury as well as to alleviate the burden of physical tasks for both impaired and able-bodied individuals. Over the last few decades assistive robots have become increasingly more capable. Many can now provide task-specific assistance and can be safe...
- Keyword:
- stroke rehabilitation, human-machine communication, human-in-the-loop RL, metrics of motion, imitation learning, and assistive robotics
- Subject:
- Physical therapy, Robotics, and Communication
- Creator:
- Kalinowska, Aleksandra Ola
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1014307 and http://dissertations.umi.com/northwestern:16780
-
- Description:
- Directional freeze-casting is a porous materials fabrication technique that is used to create materials with complex, three-dimensional pore structures. Particle suspensions are solidified under a thermal gradient, promoting anisotropic growth of dendrites and incorporation of particles within interdendritic space. A fully-solidified directional freeze-cast structure is composed of dendrites that are...
- Keyword:
- convection, microstructure, metals, porous, solidification, and freeze-casting
- Subject:
- Materials Science
- Creator:
- Scotti, Kristen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16652 and etdadmin_upload_1000506
-
- Description:
- This thesis investigates Hugo von Hofmannsthal’s undermining of soteriological poetics in his comedy Der Schwierige (“The Difficult Man”), with a focus on the complex interplay between meta-language (e.g., stage directions) and dramatic dialogue, normative and contingent speech (i.e., ‘ironic speech’). By challenging what I term the “soteriological agenda” of comedy...
- Keyword:
- Subversion, Critical Theory, Ironie, Geschwätz, Schweigen, and Gemeinschaft unendliche
- Subject:
- German literature, Philosophy, and Theater
- Creator:
- Feliciano, Hector Joniel
- Owner:
- Scholarly Digital Publishing
- Language:
- de
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1012508 and http://dissertations.umi.com/northwestern:16724
-
- Description:
- This dissertation proves several results for first passage percolation on graphs of polynomial growth.The class of limit shapes for first passage percolation with stationary weights on Cayley graphs of virtually nilpotent groups is characterized. Then strict monotonicity theorems for independent first passage percolation on graphs of polynomial growth and quasi-trees...
- Keyword:
- coarse geometry, first-passage percolation, and Cayley graphs
- Subject:
- Mathematics
- Creator:
- Gorski, Christian Stanley Edward
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16688 and etdadmin_upload_1009568
-
- Description:
- Herein, we present an overview of our studies of the morphology, dynamics, and formation of heterogeneous soft matter systems via the emerging technique of liquid phase transmission electron microscopy (LPTEM). This particular subset of materials, more commonly referred to as emulsions, is tremendously commercially and biologically relevant, encompassing applications in...
- Keyword:
- liquid phase transmission electron microscopy, soft matter, emulsions, surfactants, and polymers
- Subject:
- Polymer chemistry and Materials Science
- Creator:
- Vratsanos, Maria A.
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1009969 and http://dissertations.umi.com/northwestern:16698
-
- Description:
- Conversation is an important part of human life. Given globalization and the numerous languages around the world, it is increasingly likely that we will be communicating with others speaking in their second language (L2) rather than their first language (L1). In these situations, communication may require more effort. However, people...
- Keyword:
- Speech in noise and Targeted memory reactivation
- Subject:
- Psychology and Neurosciences
- Creator:
- Bassard, Adrianna M
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16791 and etdadmin_upload_1015288