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Description:: Advances in biosensor engineering have enabled the design of programmable molecular systems to detect a range of pathogens, nucleic acids, and chemicals. Here, we engineer and field-test a biosensor for fluoride, a major groundwater contaminant of global concern. The sensor consists of a cell-free system containing a DNA template that...
Keyword:: Diagnostic, Fluoride, Riboswitch, Cell-Free, and Synthetic Biology
Subject:: Synthetic Biology and Diagnostics
Creator:: Nancy Kelley-Loughnane, Matthew S. Verosloff, Michael C. Jewett, Walter Thavarajah, Julius B. Lucks, and Adam D. Silverman
Contributor:: This work was supported by the Air Force Research Laboratory Center of Excellence for Advanced Bioprogrammable Nanomaterials (C-ABN) Grant FA8650-15-2-5518 (to M.C.J. and J.B.L), the David and Lucile Packard Foundation (to M.C.J.), an NSF CAREER Award (1452441 to J.B.L.), and the Camille Dreyfus Teacher-Scholar Program (to M.C.J. and J.B.L.). A.D.S. was supported in part by the National Institutes of Health Training Grant (T32GM008449) through Northwestern University’s Biotechnology Training Program.
Owner:: Julius Beau Lucks
Language:: English
Date Uploaded:: 06/18/2019
Date Modified:: 01/08/2020
Date Created:: 2019-06-04
Resource Type:: Dataset
Alternate Identifier:: https://doi.org/10.21985/N2RJ64

Description:: Recent advances in cell-free gene expression (CFE) systems have enabled their use for a host of synthetic biology applications, particularly for rapid prototyping of genetic circuits and biosensors. Despite the proliferation of cell-free protein synthesis platforms, the large number of currently existing protocols for making CFE extracts muddles the collective...
Keyword:: cell-free synthetic biology, TX-TL, CFE, cell extract, genetic circuitry, in vitro protein synthesis, CFPS, and endogenous transcription
Subject:: Synthetic biology and Genetic regulation
Creator:: Nancy Kelley-Loughnane, Michael C. Jewett, Julius B. Lucks, and Adam D. Silverman
Owner:: Julius Beau Lucks
Publisher:: American Chemical Society
Language:: English
Date Uploaded:: 12/14/2018
Date Modified:: 01/07/2020
Date Created:: 12/14/18
Resource Type:: Dataset

Description:: A longstanding goal of synthetic biology has been the programmable control of cellular functions. Central to this is the creation of versatile regulatory toolsets that allow for programmable control of gene expression. Of the many regulatory molecules available, RNA regulators offer the intriguing possibility of de novo design – allowing...
Keyword:: transcription, RNA, RNA engineering, synthetic biology, and gene regulation
Subject:: Synthetic Biology and RNA engineering
Creator:: Matthew Verosloff, Alexandra Westbrook, James Chappell, and Julius B. Lucks
Owner:: Julius Beau Lucks
Publisher:: MacMillan Publishers
Language:: English
Date Uploaded:: 08/03/2017
Date Modified:: 01/07/2020
Date Created:: 2017-08-03
Resource Type:: Dataset
Alternate Identifier:: doi:10.21985/N28S9B

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