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Filtering by: Creator William L. Klein Collection Nanoscape: The Journal for Undergraduate Research in Nanoscience

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Efficient Gene Silencing in Neural Cells by Functionalized Gold Nanoparticles

Description:

Neurons are difficult to manipulate experimentally. Most transfection reagents used for gene silencing are neurotoxic, and the postmitotic state of neurons prevents the effective use of viral vectors. This study demonstrated the delivery of antisense DNA against target genes by gold nanoparticle oligonucleotide complexes (GNOs) in primary cultures of rat...

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Volume 7

Creator:

Pascale N. Lacor, Anil R. Wadhwani, and William L. Klein

Owner:

Scholarly Digital Publishing

Date Uploaded:

07/24/2018

Date Modified:

07/24/2018

Date Created:

2010

Resource Type:

Article
Stabilizing Highly Pathogenic Nanoparticles Associated with Alzheimer’s Disease

Description:

When the Aß peptides aggregate into soluble oligomeric clusters, they form central nervous system neurotoxins known as amyloid-ß-derived diffusible ligands (ADDLs). The assembly of ADDLs is currently thought to be a pathogenic process in Alzheimer's disease (AD). Understanding the molecular structure and properties of ADDLs could prove useful in the...

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Volume 5

Creator:

William L. Klein, Sarah Kate Rapoport, and Mary P. Lambert

Owner:

Scholarly Digital Publishing

Date Uploaded:

07/19/2018

Date Modified:

07/19/2018

Date Created:

2008

Resource Type:

Article
Solvent Effects on the Kinetics of Amyloid-b Oligomerization

Description:

Amyloid-β oligomers, also known as amyloid-β derived diffusible ligands (ADDLs), have been implicated in numerous studies as being a possible cause for Alzheimer’s disease (AD). The goal of this study was to investigate the kinetics of the oligomerization of the monomer amyloid-β (Aβ) into ADDLs in various ratios of dimethyl...

Keyword:

Volume 4

Creator:

Allison Meisner, William L. Klein, and Mary P. Lambert

Owner:

Scholarly Digital Publishing

Date Uploaded:

07/18/2018

Date Modified:

07/18/2018

Date Created:

2007

Resource Type:

Article

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Efficient Gene Silencing in Neural Cells by Functionalized Gold Nanoparticles

Stabilizing Highly Pathogenic Nanoparticles Associated with Alzheimer’s Disease

Solvent Effects on the Kinetics of Amyloid-b Oligomerization

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