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Quantitative Analysis of Cell Fate Decisions

Description:

Organismal development depends upon countless cell decisions to adopt particular fates at the appropriate time and place. These decisions are executed by systems of biochemical reactions called regulatory networks. Elucidating the general principles underlying the structure and function of these networks is vital to understanding all developmental processes, as well...

Keyword:

Development, Quantitative Biology, Cell Decisions, Mosaic Analysis, Drosophila, and Metabolism

Subject:

Chemical engineering and Developmental biology

Creator:

Bernasek, Sebastian Michal

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_663067 and http://dissertations.umi.com/northwestern:14676
Replication Data for: Repressive gene regulation synchronizes development with cellular metabolism

Description:

Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that weak repressors of gene expression provide the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that...

Keyword:

Development, Gene Regulation , Gene Expression, and Metabolism

Subject:

Developmental Biology

Creator:

Bagheri Lab, Carthew Lab, and Amaral Lab

Owner:

Sebastian Bernasek

Language:

English

Date Uploaded:

01/24/2019

Date Modified:

11/03/2020

Date Created:

2019-01-24

Resource Type:

Dataset

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Quantitative Analysis of Cell Fate Decisions

Replication Data for: Repressive gene regulation synchronizes development with cellular metabolism

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