Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that weak repressors of gene expression provide the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that is able to capture this feature of GRNs, we show that developmental errors that occur when a repressor is lost are greatly diminished in frequency if cellular metabolism is slowed. This dataset includes all of the simulations described in our study.

Last modified

• 11/03/2020

Creator

• Bagheri Lab
• Carthew Lab
• Amaral Lab

DOI

• https://doi.org/10.21985/N2J464

Subject

• Developmental Biology

Language

• English

Keyword

• Development
• Gene Regulation
• Gene Expression
• Metabolism

Date created

• 2019-01-24

Related url

•  https://doi.org/10.1016/j.cell.2019.06.023

Resource type

• Dataset

Rights statement

• Copyright Undetermined